Protein: ES8L2
Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2)

Gene: ES8L2, EPS8L2
Organism: Homo sapiens
Interactions: 62
UniProt ID: Q9H6S3

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0005813 - centrosome
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007266 - Rho protein signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

242935

PRKN
E3 ubiquitin-protein ligase parkin

2

3

High-throughput

0.754

High

1224910

TENS2
Tensin-2

2

19

High-throughput

0.743

High

1051058

FAK1
Focal adhesion kinase 1

1

20

High-throughput

0.656

High

456276

CATD
Cathepsin D

1

0

High-throughput

0.630

High

320413

SASH1
SAM and SH3 domain-containing protein 1

1

1

Small-scale

0.621

High

1060696

SOS1
Son of sevenless homolog 1

1

20

Small-scale

0.618

High

1316709

ABI1
Abl interactor 1

1

20

Small-scale

0.618

High

246137

KIF1B
Kinesin-like protein KIF1B

1

10

High-throughput

0.594

High

1347866

RIN3
Ras and Rab interactor 3

2

17

High-throughput

0.576

High

1234959

PKHA7
Pleckstrin homology domain-containing family A member 7

1

20

High-throughput

0.575

High

274757

DNJB6
DnaJ homolog subfamily B member 6

1

3

High-throughput

0.536

High

537916

HSP7C
Heat shock cognate 71 kDa protein

1

7

High-throughput

0.536

High

733437

CCR1
C-C chemokine receptor type 1

1

9

High-throughput

0.536

High

943133

STX17
Syntaxin-17

1

2

High-throughput

0.536

High

1332802

FNDC5
Fibronectin type III domain-containing protein 5

1

1

High-throughput

0.536

High

1334924

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.536

High

1366811

PGTA
Geranylgeranyl transferase type-2 subunit alpha

1

9

High-throughput

0.536

High

1417188

SRRT
Serrate RNA effector molecule homolog

1

1

High-throughput

0.536

High

1435146

FGOP2
FGFR1 oncogene partner 2

1

1

High-throughput

0.536

High

1435151

WASF3
Actin-binding protein WASF3

1

20

High-throughput

0.536

High

301701

WFS1
Wolframin

1

2

High-throughput

0.515

High

451271

NFL
Neurofilament light polypeptide

1

8

High-throughput

0.515

High

705556

GRN
Progranulin

1

1

High-throughput

0.515

High

1279749

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

12

High-throughput

0.515

High

602838

AATC
Aspartate aminotransferase, cytoplasmic

1

0

High-throughput

0.513

High

1387959

RM38
Large ribosomal subunit protein mL38

1

0

High-throughput

0.513

High

1435145

MBNL1
Muscleblind-like protein 1

1

0

High-throughput

0.513

High

1435152

NTNG1
Netrin-G1

1

0

High-throughput

0.513

High

423177

A4
Amyloid-beta precursor protein

1

10

High-throughput

0.501

High

1209662

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

9

High-throughput

0.501

High

1380854

TRI63
E3 ubiquitin-protein ligase TRIM63

1

19

High-throughput

0.494

High

1419294

TRI55
Tripartite motif-containing protein 55

1

20

High-throughput

0.494

High

47918

S12A8
Solute carrier family 12 member 8

1

9

High-throughput

0.489

High

325356

OR2A4
Olfactory receptor 2A4

1

1

High-throughput

0.489

High

1111274

SNW1
SNW domain-containing protein 1

1

1

High-throughput

0.489

High

1404401

CDC5L
Cell division cycle 5-like protein

1

2

High-throughput

0.489

High

1435153

SSUH2
Protein SSUH2 homolog

1

1

High-throughput

0.489

High

981967

RL23
Large ribosomal subunit protein uL14

1

2

High-throughput

0.481

High

173365

XPO1
Exportin-1

1

1

High-throughput

0.479

High

223334

PRC1
Protein regulator of cytokinesis 1

1

11

High-throughput

0.479

High

460281

CD3E
T-cell surface glycoprotein CD3 epsilon chain

1

6

Small-scale

0.479

High

556346

CADH1
Cadherin-1

1

11

High-throughput

0.479

High

986728

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

5

High-throughput

0.479

High

993334

ACTG
Actin, cytoplasmic 2

1

8

Small-scale

0.479

High

1106706

SMAD4
Mothers against decapentaplegic homolog 4

1

3

High-throughput

0.479

High

1288792

KTN1
Kinectin

1

6

High-throughput

0.479

High

1380166

FBXW7
F-box/WD repeat-containing protein 7

1

1

High-throughput

0.479

High

1386580

OPTN
Optineurin

1

20

High-throughput

0.479

High

1435147

KLH13
Kelch-like protein 13

1

1

High-throughput

0.479

High

1435148

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

109510

G5E9A7
DM1 locus, WD repeat containing

1

9

High-throughput

0.470

High

1161060

FSCN1
Fascin

1

0

High-throughput

0.458

High

261278

NSMA
Sphingomyelin phosphodiesterase 2

1

1

High-throughput

0.445

High

564375

CFTR
Cystic fibrosis transmembrane conductance regulator

1

5

High-throughput

0.445

High

1435150

S12A4
Solute carrier family 12 member 4

1

13

High-throughput

0.445

High

965244

WDR5
WD repeat-containing protein 5

1

4

High-throughput

0.437

High

554253

BMP4
Bone morphogenetic protein 4

1

1

High-throughput

0.407

High

1414724

RSRP1
Arginine/serine-rich protein 1

1

1

High-throughput

0.407

High

1180361

ASTE1
Single-strand DNA endonuclease ASTE1

2

0

High-throughput

0.328

High

1395647

CH076
Uncharacterized protein C8orf76

1

0

High-throughput

0.279

Low

1430181

PUS7L
Pseudouridylate synthase PUS7L

1

0

High-throughput

0.279

Low

1435149

SUN2
SUN domain-containing protein 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025