Protein: ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial (EC 1.2.1.-) (EC 1.2.1.4) (K(+)-activated acetaldehyde dehydrogenase) (K(+)-ACDH)

Gene: ALDH4, ALD4
Organism: Saccharomyces cerevisiae S288C
Interactions: 132
UniProt ID: P46367

Gene Ontology (top 5):
GO:0004029 - aldehyde dehydrogenase (NAD+) activity
GO:0004030 - aldehyde dehydrogenase [NAD(P)+] activity
GO:0005739 - mitochondrion
GO:0006067 - ethanol metabolic process
GO:0006090 - pyruvate metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

478308

HSP77
Import motor subunit, mitochondrial

3

5

High-throughput

0.640

High

567984

MDHM
Malate dehydrogenase, mitochondrial

3

2

Small-scale

0.640

High

767287

ALDH5
Aldehyde dehydrogenase 5, mitochondrial

1

14

High-throughput

0.618

High

803394

ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial

1

13

High-throughput

0.618

High

680813

HS104
Heat shock protein 104

3

3

Small-scale

0.585

High

342055

ATPB
ATP synthase subunit beta, mitochondrial

2

2

High-throughput

0.584

High

423869

ATPA
ATP synthase subunit alpha, mitochondrial

2

2

High-throughput

0.584

High

584174

ACON
Aconitate hydratase, mitochondrial

2

4

High-throughput

0.584

High

588132

HSP60
Heat shock protein 60, mitochondrial

2

4

High-throughput

0.584

High

705340

HSP78
Heat shock protein 78, mitochondrial

2

3

High-throughput

0.571

High

758671

TEM1
Protein TEM1

2

3

High-throughput

0.543

High

628207

SIS1
Protein SIS1

2

4

High-throughput

0.521

High

785079

MPG1
Mannose-1-phosphate guanyltransferase

2

2

High-throughput

0.521

High

511777

SSB1
Ribosome-associated molecular chaperone SSB1

2

8

High-throughput

0.504

High

589300

FKBP
FK506-binding protein 1

1

1

High-throughput

0.500

High

333981

ADH2
Alcohol dehydrogenase 2

1

2

High-throughput

0.479

High

367559

EFTU
Elongation factor Tu, mitochondrial

1

3

High-throughput

0.479

High

411033

PDC1
Pyruvate decarboxylase isozyme 1

1

2

High-throughput

0.479

High

423622

ADH3
Alcohol dehydrogenase 3, mitochondrial

1

2

High-throughput

0.479

High

439521

FUMH
Fumarate hydratase, mitochondrial

1

1

High-throughput

0.479

High

489676

MPPB
Mitochondrial-processing peptidase subunit beta

1

2

High-throughput

0.479

High

596652

ODO1
2-oxoglutarate dehydrogenase, mitochondrial

1

6

High-throughput

0.479

High

602454

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

1

High-throughput

0.479

High

606209

TRX1
Thioredoxin-1

1

4

High-throughput

0.479

High

612948

AIM17
Probable oxidoreductase AIM17

1

1

High-throughput

0.479

High

630811

STDH
Catabolic L-serine/threonine dehydratase [Includes: L-serine dehydratase

1

3

High-throughput

0.479

High

635074

ADY2
Accumulation of dyads protein 2

1

1

High-throughput

0.479

High

641320

KAD3
GTP:AMP phosphotransferase, mitochondrial

1

1

High-throughput

0.479

High

650222

COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial

1

1

High-throughput

0.479

High

657083

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

1

3

High-throughput

0.479

High

700048

PREP
Presequence protease, mitochondrial

1

4

High-throughput

0.479

High

700742

ATO2
Ammonia transport outward protein 2

1

1

High-throughput

0.479

High

715815

MDJ1
DnaJ homolog 1, mitochondrial

1

3

High-throughput

0.479

High

732926

MIC60
MICOS complex subunit MIC60

1

1

High-throughput

0.479

High

772718

MPM1
Mitochondrial peculiar membrane protein 1

1

1

High-throughput

0.479

High

783933

COQ7
5-demethoxyubiquinone hydroxylase, mitochondrial

1

1

High-throughput

0.479

High

792342

ETFB
Probable electron transfer flavoprotein subunit beta

1

1

High-throughput

0.479

High

797440

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

5

High-throughput

0.479

High

803398

ALAM
Probable alanine aminotransferase, mitochondrial

1

2

High-throughput

0.479

High

803400

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

1

High-throughput

0.479

High

803401

SUCA
Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial

1

1

High-throughput

0.479

High

803405

SAM50
Sorting assembly machinery 50 kDa subunit

1

3

High-throughput

0.479

High

803408

ABF2
ARS-binding factor 2, mitochondrial

1

4

Small-scale

0.479

High

803409

RT10
Small ribosomal subunit protein uS10m

1

1

High-throughput

0.479

High

803416

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

1

High-throughput

0.479

High

803418

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

15

High-throughput

0.479

High

803424

SMC6
Structural maintenance of chromosomes protein 6

1

3

High-throughput

0.479

High

336249

CCPR
Cytochrome c peroxidase, mitochondrial

1

0

Small-scale

0.458

High

340183

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.458

High

357312

RMAR
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.458

High

371062

SCE1
Intron-encoded endonuclease I-SceI

1

0

High-throughput

0.458

High

389945

VDAC1
Mitochondrial outer membrane protein porin 1

1

0

High-throughput

0.458

High

411243

LEU1
2-isopropylmalate synthase

1

0

High-throughput

0.458

High

637144

CYPC
Peptidyl-prolyl cis-trans isomerase C, mitochondrial

1

0

High-throughput

0.458

High

660798

HIBCH
Small ribosomal subunit protein mS47

1

0

High-throughput

0.458

High

699929

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

0

High-throughput

0.458

High

705923

XPOT
Exportin-T

1

0

High-throughput

0.458

High

729803

RM38
Large ribosomal subunit protein uL14m

1

0

High-throughput

0.458

High

750715

GRPE
GrpE protein homolog, mitochondrial

1

0

High-throughput

0.458

High

755058

PP2C7
Protein phosphatase 2C homolog 7, mitochondrial

1

0

High-throughput

0.458

High

803397

TOM22
Mitochondrial import receptor subunit TOM22

1

0

High-throughput

0.458

High

803407

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.458

High

803413

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.458

High

429725

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

2

High-throughput

0.457

High

539371

KSS1
Mitogen-activated protein kinase KSS1

1

3

High-throughput

0.457

High

579433

GBB
Guanine nucleotide-binding protein subunit beta

1

3

High-throughput

0.457

High

586417

PRP6
Pre-mRNA-splicing factor 6

1

4

High-throughput

0.457

High

594337

PP11
Serine/threonine-protein phosphatase PP1-1

1

1

High-throughput

0.457

High

628831

RAD57
DNA repair protein RAD57

1

1

High-throughput

0.457

High

698518

KU70
ATP-dependent DNA helicase II subunit 1

1

2

High-throughput

0.457

High

699409

RAD54
DNA repair and recombination protein RAD54

1

4

High-throughput

0.457

High

751275

RFC3
Replication factor C subunit 3

1

3

High-throughput

0.457

High

765947

HAT2
Histone acetyltransferase type B subunit 2

1

6

High-throughput

0.457

High

772477

RAD26
DNA repair and recombination protein RAD26

1

4

High-throughput

0.457

High

784377

COPB2
Coatomer subunit beta'

1

3

High-throughput

0.457

High

803399

RPN14
26S proteasome regulatory subunit RPN14

1

4

High-throughput

0.457

High

803406

2ABA
Protein phosphatase PP2A regulatory subunit B

1

1

High-throughput

0.457

High

803410

WDR59
Maintenance of telomere capping protein 5

1

9

High-throughput

0.457

High

803414

KU80
ATP-dependent DNA helicase II subunit 2

1

2

High-throughput

0.457

High

803415

SEN15
tRNA-splicing endonuclease subunit SEN15

1

1

High-throughput

0.457

High

803417

CIAO1
Cytosolic iron-sulfur protein assembly protein 1

1

3

High-throughput

0.457

High

803423

YP150
Putative serine/threonine-protein kinase YPL150W

1

1

High-throughput

0.457

High

424580

PYR1
Multifunctional protein URA2

1

3

High-throughput

0.445

High

494285

HSP72
Heat shock protein SSA2

1

9

High-throughput

0.445

High

383215

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.437

High

405690

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.437

High

407139

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.437

High

413581

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.437

High

425633

KAPR
cAMP-dependent protein kinase regulatory subunit

1

2

Small-scale

0.437

High

446179

MYO1
Myosin-1

1

1

Small-scale

0.437

High

454377

TBA1
Tubulin alpha-1 chain

1

5

High-throughput

0.437

High

454626

TBA3
Tubulin alpha-3 chain

1

5

High-throughput

0.437

High

472258

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

524361

CAF20
Cap-associated protein CAF20

1

2

High-throughput

0.437

High

533767

RSR1
Ras-related protein RSR1

1

1

High-throughput

0.437

High

605075

XRN1
5'-3' exoribonuclease 1

1

2

High-throughput

0.437

High

662584

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

698855

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

3

High-throughput

0.437

High

700961

SMY2
Protein SMY2

1

1

High-throughput

0.437

High

742861

GBLP
Small ribosomal subunit protein RACK1

1

3

High-throughput

0.437

High

745733

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

753860

RPN1
26S proteasome regulatory subunit RPN1

1

2

High-throughput

0.437

High

762327

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.437

High

803403

HST2
NAD-dependent protein deacetylase HST2

1

7

High-throughput

0.437

High

803404

GIS2
Zinc finger protein GIS2

1

1

High-throughput

0.437

High

360931

TBB
Tubulin beta chain

1

3

High-throughput

0.407

High

491624

HSP71
Heat shock protein SSA1

1

9

High-throughput

0.407

High

694957

HSP7F
Heat shock protein homolog SSE1

1

12

High-throughput

0.407

High

803395

PFD1
Prefoldin subunit 1

1

2

High-throughput

0.407

High

746513

IMB2
Importin subunit beta-2

2

0

High-throughput

0.318

High

420300

CALM
Calmodulin

1

0

High-throughput

0.261

Low

420507

RAD3
General transcription and DNA repair factor IIH helicase subunit XPD

1

0

High-throughput

0.261

Low

539928

RAD9
DNA repair protein RAD9

1

0

High-throughput

0.261

Low

539995

EI2BA
Translation initiation factor eIF2B subunit alpha

1

0

High-throughput

0.261

Low

605553

DBF2
Cell cycle protein kinase DBF2

1

0

High-throughput

0.261

Low

624300

GRR1
SCF E3 ubiquitin ligase complex F-box protein GRR1

1

0

High-throughput

0.261

Low

688530

KNS1
Dual specificity protein kinase KNS1

1

0

High-throughput

0.261

Low

690545

CDC12
Cell division control protein 12

1

0

High-throughput

0.261

Low

755778

SET1
Histone-lysine N-methyltransferase, H3 lysine-4 specific

1

0

High-throughput

0.261

Low

803402

SSK2
MAP kinase kinase kinase SSK2

1

0

High-throughput

0.261

Low

803411

YD131
F-box protein YDR131C

1

0

High-throughput

0.261

Low

803412

VPS64
Vacuolar protein sorting-associated protein 64

1

0

High-throughput

0.261

Low

803422

PRP11
Pre-mRNA-splicing factor PRP11

1

0

High-throughput

0.261

Low

688304

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.249

Low

716279

SPT10
Protein SPT10

1

0

High-throughput

0.249

Low

716454

SPT21
Protein SPT21

1

0

High-throughput

0.249

Low

803396

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.249

Low

803419

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

803420

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

752016

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.232

Low

803421

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024