Protein: SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC 1.3.5.1) (Iron-sulfur subunit of complex II) (Ip) (Malate dehydrogenase [quinone] iron-sulfur subunit) (EC 1.1.5.-)

Gene: SDHB
Organism: Homo sapiens
Interactions: 146
UniProt ID: P21912

Gene Ontology (top 5):
GO:0005654 - nucleoplasm
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0005759 - mitochondrial matrix
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

641749

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

10

7

Small-scale

0.970

High

65423

SDHF1
Succinate dehydrogenase assembly factor 1, mitochondrial

3

1

Small-scale

0.683

High

641842

SDHF3
Succinate dehydrogenase assembly factor 3, mitochondrial

3

1

High-throughput

0.667

High

155391

DHSD
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

1

0

High-throughput

0.656

High

641801

HSC20
Iron-sulfur cluster co-chaperone protein HscB

3

0

Small-scale

0.651

High

641797

ACD11
Acyl-CoA dehydrogenase family member 11

2

1

High-throughput

0.628

High

641804

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

2

2

High-throughput

0.621

High

641827

C560
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

1

1

High-throughput

0.618

High

641788

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

3

0

Small-scale

0.613

High

641776

CUL3
Cullin-3

2

2

High-throughput

0.611

High

641757

SYHM
Histidine--tRNA ligase, mitochondrial

2

0

High-throughput

0.602

High

641759

DPOG1
DNA polymerase subunit gamma-1

2

0

High-throughput

0.602

High

641771

TOP3A
DNA topoisomerase 3-alpha

2

0

High-throughput

0.602

High

641789

ACSF3
Malonate--CoA ligase ACSF3, mitochondrial

2

0

High-throughput

0.602

High

641790

PPCEL
Prolyl endopeptidase-like

2

0

High-throughput

0.602

High

301846

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

2

0

Small-scale

0.585

High

641834

ISCU
Iron-sulfur cluster assembly enzyme ISCU

2

0

Small-scale

0.576

High

641750

HSPA9
Stress-70 protein, mitochondrial

2

5

Small-scale

0.570

High

279647

CISY
Citrate synthase, mitochondrial

2

0

High-throughput

0.559

High

641752

CCNF
Cyclin-F

2

0

High-throughput

0.559

High

641822

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.547

High

156426

ACPM
Acyl carrier protein, mitochondrial

1

1

High-throughput

0.536

High

641774

CUL1
Cullin-1

1

2

High-throughput

0.536

High

641775

CUL2
Cullin-2

1

2

High-throughput

0.536

High

641810

PDPR
Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial

1

1

High-throughput

0.536

High

641768

TP53B
TP53-binding protein 1

1

0

High-throughput

0.529

High

641772

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.525

High

608219

EGLN
Endoglin

1

0

High-throughput

0.513

High

641782

SYLM
Leucine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

641783

P2RY6
P2Y purinoceptor 6

1

0

High-throughput

0.513

High

641785

MYLK
Myosin light chain kinase, smooth muscle

1

0

High-throughput

0.513

High

641800

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.513

High

641805

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

High-throughput

0.513

High

641816

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.513

High

641831

TX101
Testis-expressed protein 101

1

0

High-throughput

0.513

High

641836

MMAD
Cobalamin trafficking protein CblD

1

0

High-throughput

0.513

High

641840

RSAD1
Radical S-adenosyl methionine domain-containing protein 1, mitochondrial

1

0

High-throughput

0.513

High

641843

SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

1

0

High-throughput

0.513

High

641848

NPS3A
Protein NipSnap homolog 3A

1

0

High-throughput

0.513

High

161945

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

1

High-throughput

0.489

High

221082

SPY2
Protein sprouty homolog 2

1

0

High-throughput

0.486

High

641761

GEM
GTP-binding protein GEM

1

0

High-throughput

0.486

High

641815

PI3R5
Phosphoinositide 3-kinase regulatory subunit 5

1

0

High-throughput

0.486

High

208462

PJA2
E3 ubiquitin-protein ligase Praja-2

1

1

Small-scale

0.479

High

240746

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

274979

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

1

High-throughput

0.479

High

371159

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

405787

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

532354

CH60
60 kDa heat shock protein, mitochondrial

1

6

High-throughput

0.479

High

641751

MDHM
Malate dehydrogenase, mitochondrial

1

1

High-throughput

0.479

High

641763

ABCE1
ATP-binding cassette sub-family E member 1

1

1

High-throughput

0.479

High

641777

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

1

High-throughput

0.479

High

641787

FRDA
Frataxin, mitochondrial

1

1

Small-scale

0.479

High

641799

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

1

High-throughput

0.479

High

641802

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

641839

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

1

High-throughput

0.479

High

337993

ABCA1
Phospholipid-transporting ATPase ABCA1

1

0

Small-scale

0.460

High

641803

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.460

High

641851

MSRA
Mitochondrial peptide methionine sulfoxide reductase

1

0

Small-scale

0.460

High

58698

PTPC1
Protein tyrosine phosphatase domain-containing protein 1

1

0

High-throughput

0.458

High

137649

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.458

High

193990

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

217827

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

279282

TULP3
Tubby-related protein 3

1

0

High-throughput

0.458

High

315112

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

350786

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

378952

PIGR
Polymeric immunoglobulin receptor

1

0

Small-scale

0.458

High

470847

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

565145

ITA4
Integrin alpha-4

1

0

High-throughput

0.458

High

578379

BRAF
Serine/threonine-protein kinase B-raf

1

0

High-throughput

0.458

High

606219

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

641748

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.458

High

641754

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

641755

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

641756

EFTU
Elongation factor Tu, mitochondrial

1

0

High-throughput

0.458

High

641758

CDK7
Cyclin-dependent kinase 7

1

0

High-throughput

0.458

High

641760

ATX3
Ataxin-3

1

0

Small-scale

0.458

High

641762

HDAC4
Histone deacetylase 4

1

0

High-throughput

0.458

High

641765

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

641766

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

641770

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.458

High

641773

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

641778

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

0

High-throughput

0.458

High

641784

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

641792

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

641794

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

641795

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

641811

MCU
Calcium uniporter protein, mitochondrial

1

0

High-throughput

0.458

High

641813

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

641817

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.458

High

641819

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.458

High

641821

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

0

High-throughput

0.458

High

641825

EFGM
Elongation factor G, mitochondrial

1

0

High-throughput

0.458

High

641826

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.458

High

641829

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

641830

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

641837

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

641838

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

641845

OCAD1
OCIA domain-containing protein 1

1

0

Small-scale

0.458

High

641846

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

641847

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

641849

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

641852

BAG5
BAG family molecular chaperone regulator 5

1

0

High-throughput

0.458

High

641853

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.458

High

641855

DJC15
DnaJ homolog subfamily C member 15

1

0

High-throughput

0.458

High

641786

CART

1

1

Small-scale

0.457

High

327797

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

1

High-throughput

0.445

High

424772

ADT2
ADP/ATP translocase 2

1

2

Small-scale

0.445

High

429300

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

641747

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.445

High

641833

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

1

High-throughput

0.445

High

641835

S2532
Solute carrier family 25 member 32

1

2

High-throughput

0.445

High

444900

S10A9
Protein S100-A9

1

0

Small-scale

0.438

High

641841

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

255979

S19A2
Thiamine transporter 1

1

0

High-throughput

0.426

High

529076

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

619487

VCAM1
Vascular cell adhesion protein 1

1

0

High-throughput

0.426

High

641753

CNDD3
Condensin-2 complex subunit D3

1

0

High-throughput

0.426

High

641779

NPT1
Sodium-dependent phosphate transport protein 1

1

0

High-throughput

0.426

High

641793

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

641812

ZNT7
Zinc transporter 7

1

0

High-throughput

0.426

High

336589

PPN
Papilin

1

0

High-throughput

0.279

Low

641798

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.279

Low

641814

RIN3
Ras and Rab interactor 3

1

0

High-throughput

0.279

Low

641818

RAB7B
Ras-related protein Rab-7b

1

0

High-throughput

0.279

Low

641820

RTP4
Receptor-transporting protein 4

1

0

High-throughput

0.279

Low

641832

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

0

High-throughput

0.279

Low

641780

T132D
Transmembrane protein 132D

1

0

Small-scale

0.251

Low

156954

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.249

Low

293195

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

641764

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

641767

M4K2
Mitogen-activated protein kinase kinase kinase kinase 2

1

0

High-throughput

0.249

Low

641769

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.249

Low

641781

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.249

Low

641791

MIDN
Midnolin

1

0

High-throughput

0.249

Low

641796

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

641806

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

641808

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.249

Low

641809

MTMRE
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14

1

0

High-throughput

0.249

Low

641823

UBX10
UBX domain-containing protein 10

1

0

High-throughput

0.249

Low

641824

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

641844

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

641850

DS13B
Dual specificity protein phosphatase 13B

1

0

High-throughput

0.249

Low

641854

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

641828

GFI1
Zinc finger protein Gfi-1

1

0

Small-scale

0.238

Low

641807

MFSD9
Major facilitator superfamily domain-containing protein 9

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025