Protein: GIS1
Transcriptional activator/repressor GIS1

Gene: GIS1
Organism: Saccharomyces cerevisiae S288C
Interactions: 209
UniProt ID: Q03833

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

977684

GIS1
Transcriptional activator/repressor GIS1

2

15

Small-scale

0.744

High

366821

HSP82
ATP-dependent molecular chaperone HSP82

3

3

High-throughput

0.633

High

579949

YPK2
Serine/threonine-protein kinase YPK2/YKR2

1

3

High-throughput

0.618

High

653131

MIG1
Regulatory protein MIG1

1

19

High-throughput

0.618

High

765452

MIG3
Transcription corepressor MIG3

1

19

High-throughput

0.618

High

977709

HRK1
Serine/threonine-protein kinase HRK1

1

2

High-throughput

0.618

High

977714

RTK1
Probable serine/threonine-protein kinase RTK1

1

2

High-throughput

0.618

High

419951

SNF1
Carbon catabolite-derepressing protein kinase

1

0

High-throughput

0.586

High

615045

KC12
Casein kinase I homolog 2

1

0

High-throughput

0.586

High

663197

TF2B
Transcription initiation factor IIB

2

1

High-throughput

0.584

High

355995

H2B2
Histone H2B.2

2

9

High-throughput

0.571

High

977722

RUVB2
RuvB-like protein 2

2

1

High-throughput

0.571

High

618795

PP2A1
Serine/threonine-protein phosphatase PP2A-1 catalytic subunit

1

7

Small-scale

0.561

High

964726

BCK1
Serine/threonine-protein kinase BCK1/SLK1/SSP31

1

4

High-throughput

0.553

High

977698

JIP5
WD repeat-containing protein JIP5

1

3

Small-scale

0.552

High

977699

PIN3
[PSI+] inducibility protein 3

1

1

High-throughput

0.541

High

512567

SSB1
Ribosome-associated molecular chaperone SSB1

1

4

High-throughput

0.536

High

676340

XPO1
Exportin-1

1

2

High-throughput

0.536

High

977452

TAF8
Transcription initiation factor TFIID subunit 8

1

0

Small-scale

0.529

High

715650

SGS1
ATP-dependent helicase SGS1

1

1

Small-scale

0.481

High

775981

MGA2
Protein MGA2

1

1

Small-scale

0.481

High

977719

SIZ2
E3 SUMO-protein ligase SIZ2

1

2

Small-scale

0.481

High

341834

IPYR
Inorganic pyrophosphatase

1

2

High-throughput

0.479

High

423902

ATPA
ATP synthase subunit alpha, mitochondrial

1

1

High-throughput

0.479

High

443952

CYAA
Adenylate cyclase

1

2

High-throughput

0.479

High

454443

TBA1
Tubulin alpha-1 chain

1

4

High-throughput

0.479

High

540637

CYPH
Peptidyl-prolyl cis-trans isomerase

1

2

High-throughput

0.479

High

593782

DBP5
ATP-dependent RNA helicase DBP5

1

1

High-throughput

0.479

High

634187

SRO9
RNA-binding protein SRO9

1

1

High-throughput

0.479

High

694220

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

2

High-throughput

0.479

High

710317

SIP2
SNF1 protein kinase subunit beta-2

1

1

High-throughput

0.479

High

710471

TOD6
Transcriptional regulatory protein TOD6

1

1

High-throughput

0.479

High

713718

NOT4
General negative regulator of transcription subunit 4

1

2

High-throughput

0.479

High

728165

MPE1
Protein MPE1

1

1

High-throughput

0.479

High

731714

SDS22
Protein phosphatase 1 regulatory subunit SDS22

1

2

High-throughput

0.479

High

743187

BOB1
Protein BOB1

1

1

High-throughput

0.479

High

751202

GUAA
GMP synthase [glutamine-hydrolyzing]

1

1

High-throughput

0.479

High

753079

OSH3
Oxysterol-binding protein homolog 3

1

1

High-throughput

0.479

High

764124

RV167
Reduced viability upon starvation protein 167

1

1

High-throughput

0.479

High

765661

BEM2
GTPase-activating protein BEM2/IPL2

1

11

High-throughput

0.479

High

767469

DOT6
Transcriptional regulatory protein DOT6

1

1

High-throughput

0.479

High

771550

SOK1
Protein SOK1

1

1

High-throughput

0.479

High

774315

AYR1
NADPH-dependent 1-acyldihydroxyacetone phosphate reductase

1

1

High-throughput

0.479

High

774665

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

2

High-throughput

0.479

High

793604

BRE2
COMPASS component BRE2

1

3

High-throughput

0.479

High

797798

ATG18
Autophagy-related protein 18

1

3

High-throughput

0.479

High

797988

IRC5
Uncharacterized ATP-dependent helicase IRC5

1

9

High-throughput

0.479

High

819983

HOSC
Homocitrate synthase, cytosolic isozyme

1

1

High-throughput

0.479

High

860130

NMA2
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2

1

1

High-throughput

0.479

High

861287

PBP1
PAB1-binding protein 1

1

1

High-throughput

0.479

High

864674

NOG2
Nucleolar GTP-binding protein 2

1

1

High-throughput

0.479

High

865225

GOR1
Glyoxylate reductase 1

1

3

High-throughput

0.479

High

959816

2ABA
Protein phosphatase PP2A regulatory subunit B

1

2

Small-scale

0.479

High

977688

AGE1
ADP-ribosylation factor GTPase-activating protein effector protein 1

1

1

High-throughput

0.479

High

977692

GAL83
SNF1 protein kinase subunit beta-3

1

1

High-throughput

0.479

High

977694

RTN1
Reticulon-like protein 1

1

2

High-throughput

0.479

High

977696

NMA1
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

1

1

High-throughput

0.479

High

977702

PBP4
Protein PBP4

1

1

High-throughput

0.479

High

977715

HOSM
Homocitrate synthase, mitochondrial

1

1

High-throughput

0.479

High

977724

YP247
WD repeat-containing protein YPL247C

1

10

High-throughput

0.479

High

692247

PAN1
Actin cytoskeleton-regulatory complex protein PAN1

1

0

Small-scale

0.460

High

767036

ZRG8
Zinc-regulated protein 8

1

0

Small-scale

0.460

High

784978

GLDS1
Protein GDS1

1

0

Small-scale

0.460

High

866382

NIS1
Protein NIS1

1

0

Small-scale

0.460

High

977691

CSM3
Chromosome segregation in meiosis protein 3

1

0

Small-scale

0.460

High

977713

BMS1
Ribosome biogenesis protein BMS1

1

0

Small-scale

0.460

High

334981

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

0

High-throughput

0.458

High

340744

PGK
Phosphoglycerate kinase

1

0

High-throughput

0.458

High

343145

THDH
Threonine dehydratase, mitochondrial

1

0

High-throughput

0.458

High

361013

TBB
Tubulin beta chain

1

0

High-throughput

0.458

High

423631

ADH3
Alcohol dehydrogenase 3, mitochondrial

1

0

High-throughput

0.458

High

424911

IF4E
Eukaryotic translation initiation factor 4E

1

0

High-throughput

0.458

High

429764

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.458

High

482442

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

513513

PPB
Repressible alkaline phosphatase

1

0

High-throughput

0.458

High

519880

WHI2
Growth regulation protein

1

0

High-throughput

0.458

High

521051

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.458

High

522715

AAKG
5'-AMP-activated protein kinase subunit gamma

1

0

High-throughput

0.458

High

561810

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.458

High

570423

GLRX2
Glutaredoxin-2

1

0

High-throughput

0.458

High

594145

CKS1
Cyclin-dependent kinases regulatory subunit

1

0

High-throughput

0.458

High

598605

UTR1
NAD(+) kinase

1

0

High-throughput

0.458

High

598680

OSM1
Fumarate reductase 2

1

0

High-throughput

0.458

High

611028

ESS1
Peptidyl-prolyl cis-trans isomerase ESS1

1

0

High-throughput

0.458

High

622078

SSD1
Protein SSD1

1

0

High-throughput

0.458

High

626480

ERG6
Sterol 24-C-methyltransferase ERG6

1

0

High-throughput

0.458

High

627556

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

629874

RM32
Large ribosomal subunit protein bL32m

1

0

High-throughput

0.458

High

635087

DPO4
DNA polymerase IV

1

0

High-throughput

0.458

High

649298

PUR7
Phosphoribosylaminoimidazole-succinocarboxamide synthase

1

0

High-throughput

0.458

High

655157

NAM9
Small ribosomal subunit protein uS4m

1

0

High-throughput

0.458

High

685418

MLF3
Protein MLF3

1

0

High-throughput

0.458

High

693562

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.458

High

693660

SIP1
SNF1 protein kinase subunit beta-1

1

0

High-throughput

0.458

High

699369

UGPA1
UTP--glucose-1-phosphate uridylyltransferase

1

0

High-throughput

0.458

High

703955

PRS7
26S proteasome regulatory subunit 7 homolog

1

0

High-throughput

0.458

High

732515

SPC42
Spindle pole body component SPC42

1

0

High-throughput

0.458

High

740865

YC16
UPF0743 protein YCR087C-A

1

0

High-throughput

0.458

High

744086

PP2C4
Protein phosphatase 2C homolog 4

1

0

High-throughput

0.458

High

747607

OPY1
Protein OPY1

1

0

High-throughput

0.458

High

748576

RMD9L
RNA-binding protein RMD9-like, mitochondrial

1

0

High-throughput

0.458

High

753044

RRP3
ATP-dependent rRNA helicase RRP3

1

0

High-throughput

0.458

High

755393

YHP7
Uncharacterized protein YHR097C

1

0

High-throughput

0.458

High

763524

NUP60
Nucleoporin NUP60

1

0

High-throughput

0.458

High

765905

DLD3
D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3

1

0

High-throughput

0.458

High

765921

HPA3
D-amino-acid N-acetyltransferase HPA3

1

0

High-throughput

0.458

High

775159

GVP36
Protein GVP36

1

0

High-throughput

0.458

High

775957

INA22
Inner membrane assembly complex subunit 22

1

0

High-throughput

0.458

High

784963

GPD2
Glycerol-3-phosphate dehydrogenase [NAD(+)] 2, mitochondrial

1

0

High-throughput

0.458

High

809841

HIT1
Protein HIT1

1

0

High-throughput

0.458

High

812010

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.458

High

837191

PHB2
Prohibitin-2

1

0

High-throughput

0.458

High

857061

ALAM
Probable alanine aminotransferase, mitochondrial

1

0

High-throughput

0.458

High

864485

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.458

High

872851

MOT3
Transcriptional activator/repressor MOT3

1

0

High-throughput

0.458

High

887664

ACT
Actin

1

0

High-throughput

0.458

High

974423

DIG1
Down-regulator of invasive growth 1

1

0

High-throughput

0.458

High

974480

MSC1
Meiotic sister chromatid recombination protein 1

1

0

High-throughput

0.458

High

976925

OYE2
NADPH dehydrogenase 2

1

0

High-throughput

0.458

High

977686

SNX41
Sorting nexin-41

1

0

High-throughput

0.458

High

977689

HFD1
Fatty aldehyde dehydrogenase HFD1

1

0

High-throughput

0.458

High

977693

RNH1
Ribonuclease H

1

0

High-throughput

0.458

High

977707

TMC1
AN1-type zinc finger protein TMC1

1

0

High-throughput

0.458

High

977708

GYP1
GTPase-activating protein GYP1

1

0

High-throughput

0.458

High

977711

VTS1
RNA-binding protein VTS1

1

0

High-throughput

0.458

High

977717

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

977718

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

977721

AHA1
Hsp90 co-chaperone AHA1

1

0

High-throughput

0.458

High

977723

KCS1
Inositol hexakisphosphate kinase 1

1

0

High-throughput

0.458

High

977726

COA6
Cytochrome c oxidase assembly factor 6

1

0

High-throughput

0.458

High

977727

PNO1
Pre-rRNA-processing protein PNO1

1

0

High-throughput

0.458

High

356687

H4
Histone H4

1

5

High-throughput

0.445

High

492302

HSP71
Heat shock protein SSA1

1

5

High-throughput

0.445

High

494852

HSP72
Heat shock protein SSA2

1

5

High-throughput

0.445

High

629035

SCJ1
DnaJ-related protein SCJ1

1

1

High-throughput

0.445

High

635528

RSC6
Chromatin structure-remodeling complex protein RSC6

1

1

High-throughput

0.445

High

667628

MCM2
DNA replication licensing factor MCM2

1

6

High-throughput

0.445

High

667886

MCM5
Minichromosome maintenance protein 5

1

9

High-throughput

0.445

High

695434

HSP7F
Heat shock protein homolog SSE1

1

12

High-throughput

0.445

High

696168

SWI3
SWI/SNF complex subunit SWI3

1

9

High-throughput

0.445

High

696247

STH1
Nuclear protein STH1/NPS1

1

8

High-throughput

0.445

High

705600

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.445

High

744684

TAF5
Transcription initiation factor TFIID subunit 5

1

4

High-throughput

0.445

High

744903

ISW1
ISWI chromatin-remodeling complex ATPase ISW1

1

8

High-throughput

0.445

High

797938

RSC8
Chromatin structure-remodeling complex protein RSC8

1

4

High-throughput

0.445

High

859013

MCM6
DNA replication licensing factor MCM6

1

9

High-throughput

0.445

High

902038

H3
Histone H3

1

20

High-throughput

0.445

High

946147

ARP4
Actin-related protein 4

1

1

High-throughput

0.445

High

961477

CDC14
Tyrosine-protein phosphatase CDC14

1

3

High-throughput

0.445

High

977685

RUVB1
RuvB-like protein 1

1

1

High-throughput

0.445

High

977687

SXM1
Importin beta SMX1

1

11

High-throughput

0.445

High

977697

FKBP4
FK506-binding protein 4

1

2

High-throughput

0.445

High

977700

RSC2
Chromatin structure-remodeling complex subunit RSC2

1

20

High-throughput

0.445

High

977710

ISW2
ISWI chromatin-remodeling complex ATPase ISW2

1

9

High-throughput

0.445

High

977725

H2AZ
Histone H2A.Z

1

3

High-throughput

0.445

High

976072

JIP4
Uncharacterized protein JIP4

1

1

Small-scale

0.439

High

424269

CARA
Carbamoyl phosphate synthase arginine-specific small chain

1

1

High-throughput

0.437

High

495868

CP51
Lanosterol 14-alpha demethylase CYP51

1

2

High-throughput

0.437

High

568345

CAP
Adenylyl cyclase-associated protein

1

1

High-throughput

0.437

High

572828

PDI
Protein disulfide-isomerase

1

5

High-throughput

0.437

High

699521

SSO1
Protein SSO1

1

2

High-throughput

0.437

High

707128

DCA13
Protein SOF1

1

2

High-throughput

0.437

High

748554

ARPC1
Actin-related protein 2/3 complex subunit 1

1

3

High-throughput

0.437

High

865304

GIS2
Zinc finger protein GIS2

1

6

High-throughput

0.437

High

977728

DUF1
DUB-associated factor 1

1

2

High-throughput

0.437

High

577176

SNF5
SWI/SNF chromatin-remodeling complex subunit SNF5

1

0

High-throughput

0.426

High

698681

RSC7
Chromatin structure-remodeling complex subunit RSC7

1

0

High-throughput

0.426

High

858565

TAF6
Transcription initiation factor TFIID subunit 6

1

0

High-throughput

0.426

High

859354

ITC1
Imitation switch two complex protein 1

1

0

High-throughput

0.426

High

970982

TBF1
Protein TBF1

1

0

High-throughput

0.426

High

974749

RSC9
Chromatin structure-remodeling complex subunit RSC9

1

0

High-throughput

0.426

High

977520

TAF12
Transcription initiation factor TFIID subunit 12

1

0

High-throughput

0.426

High

977701

RSC3
Chromatin structure-remodeling complex protein RSC3

1

0

High-throughput

0.426

High

977705

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.426

High

797226

BUD27
Bud site selection protein 27

1

0

Small-scale

0.288

High

516909

SIR4
Regulatory protein SIR4

1

0

Small-scale

0.251

Low

706167

MFT1
THO complex subunit MFT1

1

0

Small-scale

0.251

Low

767015

FIR1
Factor interacting with REF2

1

0

Small-scale

0.251

Low

770174

PIG2
GSY2-interacting protein PIG2

1

0

Small-scale

0.251

Low

977135

ESC1
Silent chromatin protein ESC1

1

0

Small-scale

0.251

Low

524435

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.249

Low

597007

ACO1
Acyl-CoA desaturase 1

1

0

High-throughput

0.249

Low

628816

BUD5
Bud site selection protein 5

1

0

High-throughput

0.249

Low

630903

YC21A
Transposon Ty2-C Gag polyprotein

1

0

High-throughput

0.249

Low

745602

YBI6
Uncharacterized protein YBL086C

1

0

High-throughput

0.249

Low

745617

YBI1
Uncharacterized protein YBL081W

1

0

High-throughput

0.249

Low

746228

SHE1
Mitotic spindle-associated protein SHE1

1

0

High-throughput

0.249

Low

747083

IST2
Increased sodium tolerance protein 2

1

0

High-throughput

0.249

Low

747887

TOS1
Probable circularly permuted 1,3-beta-glucanase TOS1

1

0

High-throughput

0.249

Low

766569

IRC22
Increased recombination centers protein 22

1

0

High-throughput

0.249

Low

767968

SCS2
Vesicle-associated membrane protein-associated protein SCS2

1

0

High-throughput

0.249

Low

784284

VATH
V-type proton ATPase subunit H

1

0

High-throughput

0.249

Low

798355

MHP1
MAP-homologous protein 1

1

0

High-throughput

0.249

Low

809835

IMP2
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.249

Low

837231

YG51
Uncharacterized protein YGR237C

1

0

High-throughput

0.249

Low

837539

PSP2
Protein PSP2

1

0

High-throughput

0.249

Low

837556

ZDS1
Protein ZDS1

1

0

High-throughput

0.249

Low

860074

ERG26
Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating

1

0

High-throughput

0.249

Low

865967

PGA2
Processing of GAS1 and ALP protein 2

1

0

High-throughput

0.249

Low

977690

ERV41
ER-derived vesicles protein ERV41

1

0

High-throughput

0.249

Low

977695

MSC3
Meiotic sister-chromatid recombination protein 3

1

0

High-throughput

0.249

Low

977703

HBT1
Protein HBT1

1

0

High-throughput

0.249

Low

977704

AIM6
Altered inheritance of mitochondria protein 6

1

0

High-throughput

0.249

Low

977706

NBA1
Protein NBA1

1

0

High-throughput

0.249

Low

977712

RSA1
Ribosome assembly 1 protein

1

0

High-throughput

0.249

Low

977716

PER33
Pore and endoplasmic reticulum protein of 33 kDa

1

0

High-throughput

0.249

Low

977720

HSP42
Heat shock protein 42

1

0

High-throughput

0.249

Low

810724

NET1
Nucleolar protein NET1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024