Protein: PPME1
Protein phosphatase methylesterase 1 (PME-1) (EC 3.1.1.89)

Gene: PPME1
Organism: Homo sapiens
Interactions: 118
UniProt ID: Q9Y570

Gene Ontology (top 5):
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0004864 - protein phosphatase inhibitor activity
GO:0005654 - nucleoplasm
GO:0019901 - protein kinase binding
GO:0019903 - protein phosphatase binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

994432

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

11

4

Small-scale

0.879

High

977622

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

8

4

Small-scale

0.868

High

1131716

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

3

1

High-throughput

0.861

High

952038

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

3

3

High-throughput

0.839

High

1491492

PPME1
Protein phosphatase methylesterase 1

2

7

Small-scale

0.754

High

1452217

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

5

0

High-throughput

0.688

High

718071

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

9

1

Small-scale

0.687

High

1226761

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

6

2

High-throughput

0.672

High

991134

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

3

2

Small-scale

0.650

High

1143922

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

1

1

High-throughput

0.618

High

1023923

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

3

2

High-throughput

0.609

High

709034

T2EB
Transcription initiation factor IIE subunit beta

2

0

High-throughput

0.602

High

1234636

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

2

0

High-throughput

0.602

High

243403

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.584

High

538173

HSP7C
Heat shock cognate 71 kDa protein

2

0

Small-scale

0.559

High

578321

ETS2
Protein C-ets-2

1

1

High-throughput

0.541

High

691883

MK03
Mitogen-activated protein kinase 3

1

1

High-throughput

0.536

High

1395790

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

1

High-throughput

0.536

High

227006

ENSA
Alpha-endosulfine

1

0

High-throughput

0.513

High

274820

DNJB6
DnaJ homolog subfamily B member 6

1

0

High-throughput

0.513

High

1329034

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

0

High-throughput

0.513

High

1358230

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.513

High

1450400

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.513

High

1460129

PUF60
Poly(U)-binding-splicing factor PUF60

1

0

High-throughput

0.513

High

1490766

NTNG1
Netrin-G1

1

1

High-throughput

0.489

High

158034

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.479

High

257021

H2B1K
Histone H2B type 1-K

1

1

High-throughput

0.479

High

358839

LDHA
L-lactate dehydrogenase A chain

1

2

Small-scale

0.479

High

556443

CADH1
Cadherin-1

1

2

High-throughput

0.479

High

577517

ETS1
Protein C-ets-1

1

1

High-throughput

0.479

High

626414

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

1

High-throughput

0.479

High

717655

PDIA3
Protein disulfide-isomerase A3

1

2

Small-scale

0.479

High

831715

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

981201

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

High-throughput

0.479

High

1045950

TF65
Transcription factor p65

1

1

High-throughput

0.479

High

1052130

CALD1
Caldesmon

1

2

High-throughput

0.479

High

1100651

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

1

1

Small-scale

0.479

High

1431486

CAD23
Cadherin-23

1

2

Small-scale

0.479

High

386401

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

Small-scale

0.458

High

551358

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.458

High

566082

EF2
Elongation factor 2

1

0

Small-scale

0.458

High

571798

FPPS
Farnesyl pyrophosphate synthase

1

0

Small-scale

0.458

High

573291

KPYM
Pyruvate kinase PKM

1

0

Small-scale

0.458

High

573737

ENPL
Endoplasmin

1

0

Small-scale

0.458

High

583042

EZRI
Ezrin

1

0

Small-scale

0.458

High

590133

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

637808

FLNA
Filamin-A

1

0

Small-scale

0.458

High

670045

MCM3
DNA replication licensing factor MCM3

1

0

Small-scale

0.458

High

696973

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

712314

TKT
Transketolase

1

0

Small-scale

0.458

High

715003

EF1D
Elongation factor 1-delta

1

0

Small-scale

0.458

High

769615

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

799611

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

863045

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

0

Small-scale

0.458

High

879667

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

934198

XPO2
Exportin-2

1

0

Small-scale

0.458

High

981752

RAN
GTP-binding nuclear protein Ran

1

0

Small-scale

0.458

High

1026298

CLH1
Clathrin heavy chain 1

1

0

Small-scale

0.458

High

1100582

TIF1B
Transcription intermediary factor 1-beta

1

0

Small-scale

0.458

High

1139704

SYK
Lysine--tRNA ligase

1

0

Small-scale

0.458

High

1289749

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1335109

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

1338594

SYNE1
Nesprin-1

1

0

Small-scale

0.458

High

1368227

HDAC2
Histone deacetylase 2

1

0

High-throughput

0.458

High

1370500

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.458

High

1380698

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

1459453

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1490523

RUVB1
RuvB-like 1

1

0

Small-scale

0.458

High

1490538

NUDC
Nuclear migration protein nudC

1

0

Small-scale

0.458

High

330385

VENTX
Homeobox protein VENTX

1

2

High-throughput

0.445

High

1235050

PKHA7
Pleckstrin homology domain-containing family A member 7

1

1

High-throughput

0.445

High

431622

AP2A
Transcription factor AP-2-alpha

1

0

High-throughput

0.438

High

451097

LDHB
L-lactate dehydrogenase B chain

1

2

Small-scale

0.437

High

452448

PDIA1
Protein disulfide-isomerase

1

2

Small-scale

0.437

High

566889

PDIA4
Protein disulfide-isomerase A4

1

2

Small-scale

0.437

High

829030

MDHM
Malate dehydrogenase, mitochondrial

1

2

Small-scale

0.437

High

1101119

G3BP1
Ras GTPase-activating protein-binding protein 1

1

1

High-throughput

0.437

High

1256262

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

1295736

HORN
Hornerin

1

1

Small-scale

0.437

High

1325232

CMYA5
Cardiomyopathy-associated protein 5

1

4

Small-scale

0.437

High

186354

RA51B
DNA repair protein RAD51 homolog 2

1

0

High-throughput

0.426

High

1209843

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

1449941

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.426

High

1211374

S1A7B
Protein S100-A7-like 2

1

2

High-throughput

0.407

High

887383

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.391

High

1041471

ACY1
Aminoacylase-1

4

0

High-throughput

0.360

High

1062324

TGM3
Protein-glutamine gamma-glutamyltransferase E

2

0

High-throughput

0.319

High

949124

RNAS9
Inactive ribonuclease-like protein 9

1

0

High-throughput

0.279

Low

1387457

CMBL
Carboxymethylenebutenolidase homolog

1

0

High-throughput

0.279

Low

1416164

SSBP4
Single-stranded DNA-binding protein 4

1

0

High-throughput

0.279

Low

1429480

PAIP1
Polyadenylate-binding protein-interacting protein 1

1

0

High-throughput

0.279

Low

1439217

AGO4
Protein argonaute-4

1

0

High-throughput

0.279

Low

1450089

CYRIB
CYFIP-related Rac1 interactor B

1

0

High-throughput

0.279

Low

1458495

PEMT
Phosphatidylethanolamine N-methyltransferase

1

0

High-throughput

0.279

Low

1459979

PGAP2
Acyltransferase PGAP2

1

0

High-throughput

0.279

Low

1491493

WIF1
Wnt inhibitory factor 1

1

0

High-throughput

0.279

Low

1120048

KCC1A
Calcium/calmodulin-dependent protein kinase type 1

1

0

Small-scale

0.261

Low

106924

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

270416

WDR1
WD repeat-containing protein 1

1

0

Small-scale

0.249

Low

409146

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

Small-scale

0.249

Low

412882

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

446484

G6PI
Glucose-6-phosphate isomerase

1

0

Small-scale

0.249

Low

456295

CATD
Cathepsin D

1

0

Small-scale

0.249

Low

466070

ANXA6
Annexin A6

1

0

Small-scale

0.249

Low

556890

MYH1
Myosin-1

1

0

Small-scale

0.249

Low

568192

PLSL
Plastin-2

1

0

Small-scale

0.249

Low

698078

CALR
Calreticulin

1

0

Small-scale

0.249

Low

1007857

GSTO1
Glutathione S-transferase omega-1

1

0

Small-scale

0.249

Low

1063908

LG3BP
Galectin-3-binding protein

1

0

Small-scale

0.249

Low

1237979

LRC8E
Volume-regulated anion channel subunit LRRC8E

1

0

Small-scale

0.249

Low

1277035

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1363910

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

0

High-throughput

0.249

Low

1417014

CAR14
Caspase recruitment domain-containing protein 14

1

0

Small-scale

0.249

Low

1417376

TDRD1
Tudor domain-containing protein 1

1

0

High-throughput

0.249

Low

1431362

ATG5
Autophagy protein 5

1

0

High-throughput

0.249

Low

516139

CT456
Cancer/testis antigen family 45 member A6

1

0

High-throughput

0.232

Low

1104175

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025