Protein: EI2BB
Translation initiation factor eIF2B subunit beta (GCD complex subunit GCD7) (Guanine nucleotide exchange factor subunit GCD7) (eIF2B GDP-GTP exchange factor subunit beta)

Gene: EI2BB, GCD7
Organism: Saccharomyces cerevisiae S288C
Interactions: 189
UniProt ID: P32502

Gene Ontology (top 5):
GO:0002183 - cytoplasmic translational initiation
GO:0003743 - translation initiation factor activity
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005739 - mitochondrion
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

691728

EI2BE
Translation initiation factor eIF2B subunit epsilon

14

14

Small-scale

0.983

High

539962

EI2BA
Translation initiation factor eIF2B subunit alpha

12

13

Small-scale

0.981

High

521178

EI2BD
Translation initiation factor eIF2B subunit delta

11

15

Small-scale

0.979

High

593829

IF2A
Eukaryotic translation initiation factor 2 subunit alpha

5

4

Small-scale

0.919

High

446978

EI2BG
Translation initiation factor eIF2B subunit gamma

15

14

Small-scale

0.764

High

690897

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

8

7

Small-scale

0.749

High

447171

IF2B
Eukaryotic translation initiation factor 2 subunit beta

5

7

Small-scale

0.714

High

691842

MUK1
Protein MUK1

5

0

Small-scale

0.682

High

691772

EI2BB
Translation initiation factor eIF2B subunit beta

1

14

High-throughput

0.656

High

691802

MET10
Sulfite reductase [NADPH] flavoprotein component

2

1

High-throughput

0.618

High

691860

CDD
Cytidine deaminase

2

0

High-throughput

0.594

High

543401

HSC82
ATP-dependent molecular chaperone HSC82

2

7

High-throughput

0.584

High

691791

PHS
Putative pterin-4-alpha-carbinolamine dehydratase

2

0

High-throughput

0.565

High

691776

SUI1
Eukaryotic translation initiation factor eIF-1

1

1

Small-scale

0.561

High

691786

MKAR
Very-long-chain 3-oxoacyl-CoA reductase

2

2

Small-scale

0.560

High

691796

KOG1
Target of rapamycin complex 1 subunit KOG1

1

5

High-throughput

0.552

High

691850

RUVB1
RuvB-like protein 1

2

2

High-throughput

0.543

High

691837

IST1
Vacuolar protein sorting-associated protein IST1

2

2

High-throughput

0.537

High

372812

CARB
Carbamoyl phosphate synthase arginine-specific large chain

1

3

High-throughput

0.536

High

691779

XPOT
Exportin-T

1

9

High-throughput

0.536

High

691807

VAC8
Vacuolar protein 8

1

1

High-throughput

0.536

High

691811

FKH1
Fork head protein homolog 1

1

3

High-throughput

0.536

High

691846

GCN5
Histone acetyltransferase GCN5

1

3

High-throughput

0.536

High

360803

TBB
Tubulin beta chain

2

2

High-throughput

0.533

High

454244

TBA1
Tubulin alpha-1 chain

2

3

High-throughput

0.533

High

454577

TBA3
Tubulin alpha-3 chain

2

3

High-throughput

0.533

High

691818

MPG1
Mannose-1-phosphate guanyltransferase

1

10

High-throughput

0.514

High

691812

MET18
DNA repair/transcription protein MET18/MMS19

1

0

High-throughput

0.513

High

691815

SYA
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

691822

NMD5
Nonsense-mediated mRNA decay protein 5

1

0

High-throughput

0.513

High

343104

THDH
Threonine dehydratase, mitochondrial

1

2

High-throughput

0.508

High

410520

CATT
Catalase T

1

1

High-throughput

0.508

High

522681

AAKG
5'-AMP-activated protein kinase subunit gamma

1

1

High-throughput

0.508

High

546236

CATA
Peroxisomal catalase A

1

1

High-throughput

0.508

High

578515

SEC18
Vesicular-fusion protein SEC18

1

2

High-throughput

0.508

High

691804

RSP5
E3 ubiquitin-protein ligase RSP5

1

1

High-throughput

0.508

High

691823

MDV1
Mitochondrial division protein 1

1

2

High-throughput

0.508

High

691787

IF5
Eukaryotic translation initiation factor 5

1

16

Small-scale

0.501

High

365989

HSP82
ATP-dependent molecular chaperone HSP82

1

7

High-throughput

0.500

High

378316

LEU3
3-isopropylmalate dehydrogenase

1

2

High-throughput

0.500

High

381438

GAL1
Galactokinase

1

1

High-throughput

0.500

High

381691

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

2

High-throughput

0.500

High

389255

HXKA
Hexokinase-1

1

1

High-throughput

0.500

High

389378

HXKB
Hexokinase-2

1

1

High-throughput

0.500

High

393535

PMA1
Plasma membrane ATPase 1

1

1

High-throughput

0.500

High

427208

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

3

High-throughput

0.500

High

449962

HSP73
Heat shock protein SSA3

1

4

High-throughput

0.500

High

510631

SSB1
Ribosome-associated molecular chaperone SSB1

1

8

High-throughput

0.500

High

540056

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

1

High-throughput

0.500

High

587999

HSP60
Heat shock protein 60, mitochondrial

1

2

High-throughput

0.500

High

633047

MAS5
Mitochondrial protein import protein MAS5

1

3

High-throughput

0.500

High

657210

URA7
CTP synthase 1

1

1

High-throughput

0.500

High

691806

SAHH
Adenosylhomocysteinase

1

1

High-throughput

0.500

High

604520

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

2

High-throughput

0.489

High

675893

XPO1
Exportin-1

1

9

High-throughput

0.489

High

691774

VATD
V-type proton ATPase subunit D

1

1

High-throughput

0.489

High

691825

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

1

High-throughput

0.489

High

691833

SCW4
Probable family 17 glucosidase SCW4

1

1

High-throughput

0.489

High

340830

KTHY
Thymidylate kinase

1

0

High-throughput

0.486

High

440212

MET3
Sulfate adenylyltransferase

1

0

High-throughput

0.486

High

448196

F16P
Fructose-1,6-bisphosphatase

1

0

High-throughput

0.486

High

630352

PET18
Protein PET18

1

0

High-throughput

0.486

High

630397

RNQ1
[PIN+] prion protein RNQ1

1

0

High-throughput

0.486

High

687082

THI4
Thiamine thiazole synthase

1

0

High-throughput

0.486

High

691775

CACP
Carnitine O-acetyltransferase, mitochondrial

1

0

High-throughput

0.486

High

691781

UBX1
UBX domain-containing protein 1

1

0

High-throughput

0.486

High

691788

GRPE
GrpE protein homolog, mitochondrial

1

0

High-throughput

0.486

High

691794

UBA4
Adenylyltransferase and sulfurtransferase UBA4

1

0

High-throughput

0.486

High

691817

MVP1
Sorting nexin MVP1

1

0

High-throughput

0.486

High

691819

WWM1
WW domain-containing protein WWM1

1

0

High-throughput

0.486

High

691827

RIB4
6,7-dimethyl-8-ribityllumazine synthase

1

0

High-throughput

0.486

High

691832

COG2
Conserved oligomeric Golgi complex subunit 2

1

0

High-throughput

0.486

High

691838

DNM1
Dynamin-related protein DNM1

1

0

High-throughput

0.486

High

691845

SNO1
Pyridoxal 5'-phosphate synthase subunit SNO1

1

0

High-throughput

0.486

High

691857

COG4
Conserved oligomeric Golgi complex subunit 4

1

0

High-throughput

0.486

High

691864

LOT6
NAD(P)H-dependent FMN reductase LOT6

1

0

High-throughput

0.486

High

691870

GGPPS
Geranylgeranyl pyrophosphate synthase BTS1

1

0

High-throughput

0.486

High

691873

RPIA
Ribose-5-phosphate isomerase

1

0

High-throughput

0.486

High

691874

ATG34
Autophagy-related protein 34

1

0

High-throughput

0.486

High

691876

PST2
Protoplast secreted protein 2

1

0

High-throughput

0.486

High

404315

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.479

High

423441

PUR2
Bifunctional purine biosynthetic protein ADE5,7 [Includes: Phosphoribosylamine--glycine ligase

1

0

High-throughput

0.479

High

562200

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

0

High-throughput

0.479

High

636560

CDC48
Cell division control protein 48

1

0

High-throughput

0.479

High

691820

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

0

High-throughput

0.479

High

406890

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.479

High

408306

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

5

High-throughput

0.479

High

413382

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.479

High

425830

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.479

High

680533

HS104
Heat shock protein 104

1

1

High-throughput

0.479

High

691783

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.479

High

691800

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.479

High

691803

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

1

High-throughput

0.479

High

691809

SSB2
Ribosome-associated molecular chaperone SSB2

1

8

High-throughput

0.479

High

691826

RS12
Small ribosomal subunit protein eS12

1

2

High-throughput

0.479

High

691841

RS15
Small ribosomal subunit protein uS19

1

3

High-throughput

0.479

High

691851

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.479

High

691862

VAM6
Vacuolar morphogenesis protein 6

1

2

High-throughput

0.479

High

691867

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.479

High

526720

PYRE
Orotate phosphoribosyltransferase 1

1

1

High-throughput

0.464

High

541532

AMPL
Vacuolar aminopeptidase 1

1

1

High-throughput

0.464

High

667554

MCM2
DNA replication licensing factor MCM2

1

2

High-throughput

0.464

High

691795

DNPEP
Aspartyl aminopeptidase 4

1

1

High-throughput

0.464

High

691824

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

1

4

High-throughput

0.464

High

691839

LSM3
U6 snRNA-associated Sm-like protein LSm3

1

3

High-throughput

0.464

High

691840

ACT
Actin

1

2

High-throughput

0.464

High

357951

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.458

High

472085

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.458

High

524225

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.458

High

691782

BMH2
Protein BMH2

1

4

High-throughput

0.457

High

691789

YHI0
Putative proline--tRNA ligase YHR020W

1

1

High-throughput

0.457

High

691875

HSP42
Heat shock protein 42

1

5

High-throughput

0.457

High

424406

PYR1
Multifunctional protein URA2

1

3

High-throughput

0.445

High

478017

HSP77
Import motor subunit, mitochondrial

1

1

High-throughput

0.445

High

691793

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.445

High

638683

SPB4
ATP-dependent rRNA helicase SPB4

1

1

High-throughput

0.437

High

661652

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

340076

KPYK1
Pyruvate kinase 1

1

1

High-throughput

0.407

High

350764

RAS1
Ras-like protein 1

1

1

High-throughput

0.407

High

440871

ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase

1

1

High-throughput

0.407

High

555903

VATB
V-type proton ATPase subunit B

1

2

High-throughput

0.407

High

560928

EF3A
Elongation factor 3A

1

1

High-throughput

0.407

High

691777

PRS7
26S proteasome regulatory subunit 7 homolog

1

1

High-throughput

0.407

High

691799

TCPG
T-complex protein 1 subunit gamma

1

5

High-throughput

0.407

High

691810

PRS4
26S proteasome regulatory subunit 4 homolog

1

1

High-throughput

0.407

High

691834

PRS10
26S proteasome subunit RPT4

1

2

High-throughput

0.407

High

686882

P5CR
Pyrroline-5-carboxylate reductase

2

0

High-throughput

0.326

High

691871

HUA2
Protein HUA2

2

0

High-throughput

0.323

High

691773

RTG2
Retrograde regulation protein 2

2

0

High-throughput

0.310

High

636040

CSM1
Monopolin complex subunit CSM1

2

0

High-throughput

0.307

High

691859

ATG17
Autophagy-related protein 17

2

0

High-throughput

0.307

High

691861

VAC14
Vacuole morphology and inheritance protein 14

2

0

High-throughput

0.307

High

691868

RDR1
Protein RDR1

2

0

High-throughput

0.307

High

691801

MBB1
Uncharacterized protein MBB1

2

0

High-throughput

0.295

High

514617

FUS1
Nuclear fusion protein FUS1

1

0

High-throughput

0.282

High

691780

SPC29
Spindle pole component 29

1

0

High-throughput

0.282

High

691831

THG1
tRNA(His) guanylyltransferase

1

0

High-throughput

0.282

High

691869

TGL5
Triacylglycerol lipase 5

1

0

High-throughput

0.282

High

633839

SGF29
SAGA-associated factor 29

1

0

High-throughput

0.279

Low

691798

FET3
Iron transport multicopper oxidase FET3

1

0

High-throughput

0.279

Low

649284

PUR7
Phosphoribosylaminoimidazole-succinocarboxamide synthase

1

0

High-throughput

0.269

Low

396175

ARGR2
Arginine metabolism regulation protein II

1

0

High-throughput

0.265

Low

588984

TYR1
Prephenate dehydrogenase [NADP(+)]

1

0

High-throughput

0.265

Low

600300

DAL82
Protein DAL82

1

0

High-throughput

0.265

Low

602646

MCK1
Protein kinase MCK1

1

0

High-throughput

0.265

Low

613110

URE2
Transcriptional regulator URE2

1

0

High-throughput

0.265

Low

641124

DAL80
Nitrogen regulatory protein DAL80

1

0

High-throughput

0.265

Low

648300

GYS2
Glycogen [starch] synthase isoform 2

1

0

High-throughput

0.265

Low

649013

URK1
Uridine kinase

1

0

High-throughput

0.265

Low

657125

UBC8
Ubiquitin-conjugating enzyme E2-24 kDa

1

0

High-throughput

0.265

Low

691778

DUT
Deoxyuridine 5'-triphosphate nucleotidohydrolase

1

0

High-throughput

0.265

Low

691784

PAN3
PAN2-PAN3 deadenylation complex subunit PAN3

1

0

High-throughput

0.265

Low

691785

PBP2
PAB1-binding protein 2

1

0

High-throughput

0.265

Low

691790

YHR2
Uncharacterized trans-sulfuration enzyme YHR112C

1

0

High-throughput

0.265

Low

691792

YAP3
AP-1-like transcription factor YAP3

1

0

High-throughput

0.265

Low

691805

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

1

0

High-throughput

0.265

Low

691813

SER33
D-3-phosphoglycerate dehydrogenase 2

1

0

High-throughput

0.265

Low

691814

YIV5
Uncharacterized oxidoreductase YIR035C

1

0

High-throughput

0.265

Low

691816

YJV8
Putative acetyltransferase YJL218W

1

0

High-throughput

0.265

Low

691821

COM1
DNA endonuclease SAE2

1

0

High-throughput

0.265

Low

691828

GCH1
GTP cyclohydrolase 1

1

0

High-throughput

0.265

Low

691830

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.265

Low

691835

PRA1
Prenylated Rab acceptor 1

1

0

High-throughput

0.265

Low

691836

SNZ2
Probable pyridoxal 5'-phosphate synthase subunit SNZ2

1

0

High-throughput

0.265

Low

691843

AAD16
Putative aryl-alcohol dehydrogenase AAD16

1

0

High-throughput

0.265

Low

691844

DIG1
Down-regulator of invasive growth 1

1

0

High-throughput

0.265

Low

691847

DIG2
Down-regulator of invasive growth 2

1

0

High-throughput

0.265

Low

691852

KFA
Kynurenine formamidase

1

0

High-throughput

0.265

Low

691853

URC2
Uracil catabolism protein 2

1

0

High-throughput

0.265

Low

691856

CYK2
Cytokinesis protein 2

1

0

High-throughput

0.265

Low

691858

SFH1
Chromatin structure-remodeling complex subunit SFH1

1

0

High-throughput

0.265

Low

691863

YD144
Uncharacterized protein YDL144C

1

0

High-throughput

0.265

Low

691865

ALR1
Magnesium transporter ALR1

1

0

High-throughput

0.265

Low

691866

CUE5
Ubiquitin-binding protein CUE5

1

0

High-throughput

0.265

Low

691872

FCY1
Cytosine deaminase

1

0

High-throughput

0.265

Low

691877

JLP1
Alpha-ketoglutarate-dependent sulfonate dioxygenase

1

0

High-throughput

0.265

Low

691879

YO21A
Transposon Ty2-OR1 Gag polyprotein

1

0

High-throughput

0.265

Low

691880

NTPPA
dTTP/UTP pyrophosphatase

1

0

High-throughput

0.265

Low

691881

DET1
Broad-range acid phosphatase DET1

1

0

High-throughput

0.265

Low

560603

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.261

Low

691848

ARX1
Probable metalloprotease ARX1

1

0

High-throughput

0.249

Low

691849

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

0

High-throughput

0.249

Low

691854

TAF7
Transcription initiation factor TFIID subunit 7

1

0

High-throughput

0.249

Low

691878

RIB2
Bifunctional protein RIB2 [Includes: tRNA pseudouridine(32) synthase, cytoplasmic

1

0

High-throughput

0.249

Low

691797

SPT8
Transcription factor SPT8

1

0

High-throughput

0.232

Low

691808

IMB4
Importin subunit beta-4

1

0

High-throughput

0.232

Low

691829

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.232

Low

691855

TAF9
Transcription initiation factor TFIID subunit 9

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024