Protein: SSB
Single-stranded DNA-binding protein (SSB) (Helix-destabilizing protein)

Gene: SSB
Organism: Escherichia coli K-12
Interactions: 60
UniProt ID: P0AGE0

Gene Ontology (top 5):
GO:0000725 - recombinational repair
GO:0003697 - single-stranded DNA binding
GO:0005829 - cytosol
GO:0006260 - DNA replication
GO:0006261 - DNA-templated DNA replication

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

501518

SSB
Single-stranded DNA-binding protein

2

1

Small-scale

0.778

High

501536

HOLC
DNA polymerase III subunit chi

5

0

Small-scale

0.676

High

501528

PRIA
Replication restart protein PriA

2

2

Small-scale

0.602

High

501531

RECG
ATP-dependent DNA helicase RecG

2

2

High-throughput

0.601

High

492510

RL7
Large ribosomal subunit protein bL12

2

1

High-throughput

0.584

High

492612

RL19
Large ribosomal subunit protein bL19

2

1

High-throughput

0.584

High

501541

RL24
Large ribosomal subunit protein uL24

2

1

High-throughput

0.584

High

501542

RL4
Large ribosomal subunit protein uL4

2

1

High-throughput

0.584

High

496903

LON
Lon protease

2

2

High-throughput

0.571

High

500423

GYRA
DNA gyrase subunit A

2

1

High-throughput

0.571

High

500846

PARC
DNA topoisomerase 4 subunit A

2

1

High-throughput

0.571

High

501519

YFIF
Uncharacterized tRNA/rRNA methyltransferase YfiF

2

2

High-throughput

0.571

High

492939

RL28
Large ribosomal subunit protein bL28

2

0

High-throughput

0.559

High

493096

RL33
Large ribosomal subunit protein bL33

2

0

High-throughput

0.559

High

501535

HOLD
DNA polymerase III subunit psi

2

0

High-throughput

0.559

High

361751

PHSM
Maltodextrin phosphorylase

2

0

High-throughput

0.547

High

395117

DPO3E
DNA polymerase III subunit epsilon

2

0

High-throughput

0.547

High

494102

RS4
Small ribosomal subunit protein uS4

2

0

High-throughput

0.547

High

494626

RPOA
DNA-directed RNA polymerase subunit alpha

2

0

High-throughput

0.547

High

499152

HNS
DNA-binding protein H-NS

2

0

High-throughput

0.547

High

501539

RL2
Large ribosomal subunit protein uL2

2

0

High-throughput

0.547

High

501545

DCEA
Glutamate decarboxylase alpha

2

0

High-throughput

0.547

High

445413

DPO3X
DNA polymerase III subunit tau

1

3

High-throughput

0.541

High

492324

RECO
DNA repair protein RecO

1

0

Small-scale

0.537

High

501534

DING
ATP-dependent DNA helicase DinG

1

0

Small-scale

0.513

High

501527

PEPD
Cytosol non-specific dipeptidase

1

0

High-throughput

0.513

High

501533

RHLE
ATP-dependent RNA helicase RhlE

1

0

High-throughput

0.513

High

501548

YBCN
Uncharacterized protein YbcN

1

0

High-throughput

0.513

High

498541

DNAG
DNA primase

1

0

Small-scale

0.505

High

501524

UNG
Uracil-DNA glycosylase

1

1

High-throughput

0.489

High

444299

TOP1
DNA topoisomerase 1

1

3

High-throughput

0.445

High

493249

RS10
Small ribosomal subunit protein uS10

1

1

High-throughput

0.445

High

501525

TOP3
DNA topoisomerase 3

1

3

High-throughput

0.445

High

501526

RECQ
ATP-dependent DNA helicase RecQ

1

1

High-throughput

0.445

High

501532

MNME
tRNA modification GTPase MnmE

1

3

High-throughput

0.445

High

501540

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.445

High

501543

RL22
Large ribosomal subunit protein uL22

1

1

High-throughput

0.445

High

420223

EX1
Exodeoxyribonuclease I

1

0

High-throughput

0.426

High

491105

DNAK
Chaperone protein DnaK

1

0

High-throughput

0.426

High

495828

RPOC
DNA-directed RNA polymerase subunit beta'

1

0

High-throughput

0.426

High

495910

RPOB
DNA-directed RNA polymerase subunit beta

1

0

High-throughput

0.426

High

496788

SLYD
FKBP-type peptidyl-prolyl cis-trans isomerase SlyD

1

0

High-throughput

0.426

High

498555

HOLE
DNA polymerase III subunit theta

1

0

High-throughput

0.426

High

499060

DBHA
DNA-binding protein HU-alpha

1

0

High-throughput

0.426

High

501523

DPO3A
DNA polymerase III subunit alpha

1

0

High-throughput

0.426

High

501529

PARE
DNA topoisomerase 4 subunit B

1

0

High-throughput

0.426

High

501544

RS21
Small ribosomal subunit protein bS21

1

0

High-throughput

0.426

High

494547

RNH
Ribonuclease HI

1

2

High-throughput

0.407

High

501520

EFTU1
Elongation factor Tu 1

1

2

High-throughput

0.407

High

501521

EFTU2
Elongation factor Tu 2

1

2

High-throughput

0.407

High

501530

RECJ
Single-stranded-DNA-specific exonuclease RecJ

1

1

High-throughput

0.407

High

489251

UBIB
Probable protein kinase UbiB

2

0

High-throughput

0.298

High

367540

PHR
Deoxyribodipyrimidine photo-lyase

1

0

High-throughput

0.279

Low

498202

ATPG
ATP synthase gamma chain

1

0

High-throughput

0.249

Low

501522

SECA
Protein translocase subunit SecA

1

0

High-throughput

0.232

Low

501537

NOHA
Prophage DNA-packing protein NohA

1

0

High-throughput

0.232

Low

501538

MTGA
Biosynthetic peptidoglycan transglycosylase

1

0

High-throughput

0.232

Low

501546

YAIX
Putative uncharacterized acetyltransferase YaiX

1

0

High-throughput

0.232

Low

501547

ARNA
Bifunctional polymyxin resistance protein ArnA

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025