Protein: RHG18
Rho GTPase-activating protein 18 (MacGAP) (Rho-type GTPase-activating protein 18)

Gene: RHG18, ARHGAP18
Organism: Homo sapiens
Interactions: 104
UniProt ID: Q8N392

Gene Ontology (top 5):
GO:0001726 - ruffle
GO:0005096 - GTPase activator activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005881 - cytoplasmic microtubule

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

76489

B4DXL2
cDNA FLJ58638, highly similar to Homo sapiens Rho GTPase activating protein 28

1

14

High-throughput

0.618

High

976406

RB11A
Ras-related protein Rab-11A

1

2

High-throughput

0.618

High

978157

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

1324934

CD2AP
CD2-associated protein

1

20

High-throughput

0.618

High

1106608

SMAD4
Mothers against decapentaplegic homolog 4

2

3

High-throughput

0.611

High

1258732

PREX2
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein

2

8

High-throughput

0.571

High

1280056

FGD2
FYVE, RhoGEF and PH domain-containing protein 2

2

8

High-throughput

0.571

High

1324912

PKH4B
Pleckstrin homology domain-containing family G member 4B

2

4

High-throughput

0.571

High

253364

JAK2
Tyrosine-protein kinase JAK2

1

20

High-throughput

0.536

High

274658

DNJB6
DnaJ homolog subfamily B member 6

1

1

High-throughput

0.536

High

997850

CSK21
Casein kinase II subunit alpha

1

12

High-throughput

0.536

High

1324898

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.536

High

1324903

DOK4
Docking protein 4

1

4

High-throughput

0.536

High

1324906

PGTA
Geranylgeranyl transferase type-2 subunit alpha

1

4

High-throughput

0.536

High

1324902

BBS1
BBSome complex member BBS1

1

0

High-throughput

0.513

High

1324909

APC16
Anaphase-promoting complex subunit 16

1

0

High-throughput

0.513

High

1324917

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.513

High

1324935

RM42
Large ribosomal subunit protein mL42

1

0

High-throughput

0.513

High

322667

KDM4B
Lysine-specific demethylase 4B

1

3

High-throughput

0.489

High

1322327

ZN444
Zinc finger protein 444

1

12

High-throughput

0.489

High

1324899

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

15

High-throughput

0.489

High

1324905

ANR49
Ankyrin repeat domain-containing protein 49

1

9

High-throughput

0.489

High

1324925

PALS2
Protein PALS2

1

4

High-throughput

0.481

High

130984

HIP1
Huntingtin-interacting protein 1

1

3

High-throughput

0.479

High

135963

P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

1

1

High-throughput

0.479

High

138213

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

1

High-throughput

0.479

High

171732

GAK
Cyclin-G-associated kinase

1

8

High-throughput

0.479

High

175118

SC16A
Protein transport protein Sec16A

1

4

High-throughput

0.479

High

178036

LSM1
U6 snRNA-associated Sm-like protein LSm1

1

2

High-throughput

0.479

High

225834

AP1G1
AP-1 complex subunit gamma-1

1

8

High-throughput

0.479

High

228315

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

3

High-throughput

0.479

High

242265

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.479

High

323753

AP2A2
AP-2 complex subunit alpha-2

1

8

High-throughput

0.479

High

329466

EPN2
Epsin-2

1

3

High-throughput

0.479

High

347166

BAG2
BAG family molecular chaperone regulator 2

1

4

High-throughput

0.479

High

390664

TFR1
Transferrin receptor protein 1

1

1

High-throughput

0.479

High

483149

CLCA
Clathrin light chain A

1

2

High-throughput

0.479

High

483366

CLCB
Clathrin light chain B

1

2

High-throughput

0.479

High

537506

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.479

High

556208

CADH1
Cadherin-1

1

8

High-throughput

0.479

High

641964

CD9
CD9 antigen

1

1

High-throughput

0.479

High

684306

DDX6
Probable ATP-dependent RNA helicase DDX6

1

5

High-throughput

0.479

High

690297

STOM
Stomatin

1

4

High-throughput

0.479

High

801414

HSPA9
Stress-70 protein, mitochondrial

1

8

High-throughput

0.479

High

839794

EPS15
Epidermal growth factor receptor substrate 15

1

5

High-throughput

0.479

High

922592

AP2S1
AP-2 complex subunit sigma

1

3

High-throughput

0.479

High

930991

HSP72
Heat shock-related 70 kDa protein 2

1

4

High-throughput

0.479

High

938239

SEC13
Protein SEC13 homolog

1

4

High-throughput

0.479

High

974327

LSM6
U6 snRNA-associated Sm-like protein LSm6

1

7

High-throughput

0.479

High

989047

AP2B1
AP-2 complex subunit beta

1

10

High-throughput

0.479

High

1063426

GOGA2
Golgin subfamily A member 2

1

8

High-throughput

0.479

High

1083275

AP1B1
AP-1 complex subunit beta-1

1

9

High-throughput

0.479

High

1094585

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

5

High-throughput

0.479

High

1107569

PICAL
Phosphatidylinositol-binding clathrin assembly protein

1

1

High-throughput

0.479

High

1129836

EPN4
Clathrin interactor 1

1

3

High-throughput

0.479

High

1231847

IQEC1
IQ motif and SEC7 domain-containing protein 1

1

3

High-throughput

0.479

High

1241469

EDC4
Enhancer of mRNA-decapping protein 4

1

2

High-throughput

0.479

High

1254617

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

1316171

DCP1B
mRNA-decapping enzyme 1B

1

5

High-throughput

0.479

High

1316407

XRN1
5'-3' exoribonuclease 1

1

1

High-throughput

0.479

High

1324900

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

5

High-throughput

0.479

High

1324901

LS14A
Protein LSM14 homolog A

1

2

High-throughput

0.479

High

1324904

SMAP2
Stromal membrane-associated protein 2

1

4

High-throughput

0.479

High

1324907

AP2M1
AP-2 complex subunit mu

1

2

High-throughput

0.479

High

1324908

REPS1
RalBP1-associated Eps domain-containing protein 1

1

6

High-throughput

0.479

High

1324911

EDC3
Enhancer of mRNA-decapping protein 3

1

1

High-throughput

0.479

High

1324916

AP1M1
AP-1 complex subunit mu-1

1

2

High-throughput

0.479

High

1324919

WDR6
tRNA

1

8

High-throughput

0.479

High

1324920

DCP1A
mRNA-decapping enzyme 1A

1

1

High-throughput

0.479

High

1324922

BMP2K
BMP-2-inducible protein kinase

1

6

High-throughput

0.479

High

1324926

CHMP5
Charged multivesicular body protein 5

1

2

High-throughput

0.479

High

1324927

CACO1
Calcium-binding and coiled-coil domain-containing protein 1

1

9

High-throughput

0.479

High

1324928

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

1324931

LSM2
U6 snRNA-associated Sm-like protein LSm2

1

5

High-throughput

0.479

High

1324933

LSM4
U6 snRNA-associated Sm-like protein LSm4

1

5

High-throughput

0.479

High

1324936

ENPP4
Bis(5'-adenosyl)-triphosphatase ENPP4

1

1

High-throughput

0.479

High

278896

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.458

High

336719

BAG4
BAG family molecular chaperone regulator 4

1

0

High-throughput

0.458

High

925661

IST1
IST1 homolog

1

0

High-throughput

0.458

High

1026127

CLH1
Clathrin heavy chain 1

1

0

High-throughput

0.458

High

1128779

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

1159939

MEA1
Male-enhanced antigen 1

1

0

High-throughput

0.458

High

1208706

NEXMI
Neurite extension and migration factor

1

0

High-throughput

0.458

High

1224804

AP1AR
AP-1 complex-associated regulatory protein

1

0

High-throughput

0.458

High

1248012

AFTIN
Aftiphilin

1

0

High-throughput

0.458

High

1287096

PATL1
Protein PAT1 homolog 1

1

0

High-throughput

0.458

High

1306901

DCP2
m7GpppN-mRNA hydrolase

1

0

High-throughput

0.458

High

1324921

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.458

High

1324924

GTSE1
G2 and S phase-expressed protein 1

1

0

High-throughput

0.458

High

1324929

SYNRG
Synergin gamma

1

0

High-throughput

0.458

High

1324930

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

0

High-throughput

0.458

High

1324932

MARF1
Meiosis regulator and mRNA stability factor 1

1

0

High-throughput

0.458

High

1093147

STK4
Serine/threonine-protein kinase 4

1

11

High-throughput

0.445

High

1324914

MPH6
M-phase phosphoprotein 6

1

0

High-throughput

0.438

High

353443

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

932909

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

3

High-throughput

0.437

High

1242016

SCYL2
SCY1-like protein 2

1

1

High-throughput

0.437

High

1324910

ZBT10
Zinc finger and BTB domain-containing protein 10

1

14

High-throughput

0.437

High

1324913

MA7D2
MAP7 domain-containing protein 2

1

13

High-throughput

0.437

High

1324918

YTDC2
3'-5' RNA helicase YTHDC2

1

2

High-throughput

0.437

High

1324915

MND1
Meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.279

Low

1324923

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.279

Low

1085966

PNRC1
Proline-rich nuclear receptor coactivator 1

1

0

High-throughput

0.249

Low

1210424

TSBP1
Testis-expressed basic protein 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025