Protein: 5NTC
Cytosolic purine 5'-nucleotidase (EC 3.1.3.5) (EC 3.1.3.99) (Cytosolic 5'-nucleotidase II) (cN-II) (Cytosolic IMP/GMP-specific 5'-nucleotidase) (Cytosolic nucleoside phosphotransferase 5'N) (EC 2.7.1.77) (High Km 5'-nucleotidase)

Gene: 5NTC, NT5C2
Organism: Homo sapiens
Interactions: 59
UniProt ID: P49902

Gene Ontology (top 5):
GO:0000255 - allantoin metabolic process
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006202 - GMP catabolic process to guanine

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

892247

5NTC
Cytosolic purine 5'-nucleotidase

2

6

High-throughput

0.815

High

892283

NDK7
Nucleoside diphosphate kinase homolog 7

2

1

High-throughput

0.646

High

892248

FXR2
RNA-binding protein FXR2

2

2

High-throughput

0.640

High

892262

MOB3B
MOB kinase activator 3B

2

2

High-throughput

0.640

High

892258

NUD18
8-oxo-dGDP phosphatase NUDT18

2

0

High-throughput

0.613

High

892277

SNX15
Sorting nexin-15

2

0

High-throughput

0.585

High

241097

PRKN
E3 ubiquitin-protein ligase parkin

2

5

High-throughput

0.584

High

892264

GLCTK
Glycerate kinase

2

0

High-throughput

0.580

High

140184

SDCB1
Syntenin-1

1

1

High-throughput

0.573

High

892259

MOB3C
MOB kinase activator 3C

1

2

High-throughput

0.573

High

892261

MOB1B
MOB kinase activator 1B

1

2

High-throughput

0.573

High

892252

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

2

0

High-throughput

0.547

High

892260

PREX2
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein

2

0

High-throughput

0.547

High

892279

RHG23
Rho GTPase-activating protein 23

2

0

High-throughput

0.547

High

529351

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.536

High

892256

RHG36
Rho GTPase-activating protein 36

2

1

High-throughput

0.521

High

208202

RRP8
Ribosomal RNA-processing protein 8

1

0

High-throughput

0.513

High

274504

DNJB6
DnaJ homolog subfamily B member 6

1

0

High-throughput

0.513

High

892275

PAAT
ATPase PAAT

1

0

High-throughput

0.513

High

892276

E41L5
Band 4.1-like protein 5

1

0

High-throughput

0.513

High

208805

ZBT24
Zinc finger and BTB domain-containing protein 24

1

1

High-throughput

0.489

High

290489

SURF6
Surfeit locus protein 6

1

1

High-throughput

0.489

High

892282

NTNG1
Netrin-G1

1

1

High-throughput

0.489

High

892284

WIF1
Wnt inhibitory factor 1

1

2

High-throughput

0.489

High

395708

ESR1
Estrogen receptor

1

2

High-throughput

0.479

High

411585

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.479

High

892249

DUS3
Dual specificity protein phosphatase 3

1

1

High-throughput

0.479

High

892250

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

892257

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

892266

WDTC1
WD and tetratricopeptide repeats protein 1

1

1

High-throughput

0.479

High

892270

SNX27
Sorting nexin-27

1

1

High-throughput

0.479

High

138020

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

0

High-throughput

0.458

High

776939

PPM1A
Protein phosphatase 1A

1

0

High-throughput

0.458

High

892251

1433E
14-3-3 protein epsilon

1

0

Small-scale

0.458

High

892253

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

892255

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.458

High

892263

ZN598
E3 ubiquitin-protein ligase ZNF598

1

0

High-throughput

0.458

High

892265

CMTR1
Cap-specific mRNA

1

0

High-throughput

0.458

High

892268

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

892269

FBF1
Fas-binding factor 1

1

0

High-throughput

0.458

High

892271

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.458

High

892272

ASB2
Ankyrin repeat and SOCS box protein 2

1

0

High-throughput

0.458

High

892280

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

142305

PEX7
Peroxisomal targeting signal 2 receptor

1

1

High-throughput

0.445

High

576190

PO2F1
POU domain, class 2, transcription factor 1

1

1

Small-scale

0.437

High

588210

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

694934

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

767704

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

413418

P53
Cellular tumor antigen p53

1

0

Small-scale

0.426

High

892278

HPBP1
Hsp70-binding protein 1

4

0

High-throughput

0.360

High

869821

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

1

0

High-throughput

0.299

High

892274

NOC4L
Nucleolar complex protein 4 homolog

1

0

High-throughput

0.282

High

892267

F133A
Protein FAM133A

1

0

High-throughput

0.279

Low

892281

PRDM4
PR domain zinc finger protein 4

1

0

High-throughput

0.279

Low

892273

ELF4
ETS-related transcription factor Elf-4

1

0

High-throughput

0.261

Low

353109

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

892254

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.249

Low

330078

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025