Protein: HEL1
E3 ubiquitin-protein ligase HEL1 (EC 2.3.2.31) (Histone E3 ligase 1) (RING-type E3 ubiquitin transferase HEL1)

Gene: HEL1
Organism: Saccharomyces cerevisiae S288C
Interactions: 12
UniProt ID: P36113

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0005737 - cytoplasm
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0008270 - zinc ion binding
GO:0016567 - protein ubiquitination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

585702

UBC4
Ubiquitin-conjugating enzyme E2 4

1

20

Small-scale

0.724

High

509496

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

20

High-throughput

0.647

High

781502

CDC53
Cell division control protein 53

1

14

Small-scale

0.621

High

781500

H3
Histone H3

1

4

Small-scale

0.553

High

781497

ETP1
RING finger protein ETP1

1

9

High-throughput

0.536

High

382032

H4
Histone H4

1

4

Small-scale

0.512

High

408315

GAL1
Galactokinase

1

1

High-throughput

0.500

High

646371

RAD53
Serine/threonine-protein kinase RAD53

1

6

Small-scale

0.479

High

555056

G6PI
Glucose-6-phosphate isomerase

1

1

High-throughput

0.457

High

781501

THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20

1

1

High-throughput

0.457

High

781499

SSB2
Ribosome-associated molecular chaperone SSB2

1

9

High-throughput

0.445

High

781498

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025