Protein: G6PI
Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI)

Gene: G6PI, PGI1
Organism: Saccharomyces cerevisiae S288C
Interactions: 244
UniProt ID: P12709

Gene Ontology (top 5):
GO:0004347 - glucose-6-phosphate isomerase activity
GO:0005739 - mitochondrion
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0006094 - gluconeogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

554985

G6PI
Glucose-6-phosphate isomerase

2

3

High-throughput

0.754

High

555084

RSP5
E3 ubiquitin-protein ligase RSP5

3

2

Small-scale

0.651

High

543627

SSB1
Ribosome-associated molecular chaperone SSB1

3

2

High-throughput

0.633

High

522881

HSP71
Heat shock protein SSA1

3

2

High-throughput

0.624

High

555029

SEC1
Protein transport protein SEC1

2

0

High-throughput

0.595

High

555014

SIS1
Protein SIS1

2

0

High-throughput

0.576

High

525770

HSP72
Heat shock protein SSA2

2

2

High-throughput

0.571

High

554994

HSC82
ATP-dependent molecular chaperone HSC82

2

1

High-throughput

0.571

High

555140

COFI
Cofilin

2

0

High-throughput

0.569

High

555105

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

0

High-throughput

0.559

High

464535

PBS2
MAP kinase kinase PBS2

2

1

High-throughput

0.543

High

555041

SNQ2
Protein SNQ2

1

1

High-throughput

0.541

High

555134

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.536

High

555170

AP1G1
AP-1 complex subunit gamma-1

1

1

High-throughput

0.536

High

555121

BRE5
UBP3-associated protein BRE5

1

0

High-throughput

0.513

High

469973

FUMH
Fumarate hydratase, mitochondrial

1

1

High-throughput

0.500

High

518181

IF4A
ATP-dependent RNA helicase eIF4A

1

1

High-throughput

0.500

High

555001

GBB
Guanine nucleotide-binding protein subunit beta

1

1

High-throughput

0.500

High

555007

NPR1
Nitrogen permease reactivator protein

1

2

High-throughput

0.500

High

555009

RFA1
Replication factor A protein 1

1

1

High-throughput

0.500

High

555011

KC11
Casein kinase I homolog 1

1

1

High-throughput

0.500

High

555016

RV161
Reduced viability upon starvation protein 161

1

1

High-throughput

0.500

High

555069

RFC3
Replication factor C subunit 3

1

1

High-throughput

0.500

High

555081

RV167
Reduced viability upon starvation protein 167

1

1

High-throughput

0.500

High

555109

UBC13
Ubiquitin-conjugating enzyme E2 13

1

1

High-throughput

0.500

High

555112

PPP5
Serine/threonine-protein phosphatase T

1

1

High-throughput

0.500

High

555114

RPN14
26S proteasome regulatory subunit RPN14

1

1

High-throughput

0.500

High

555132

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

3

High-throughput

0.500

High

555143

STE20
Serine/threonine-protein kinase STE20

1

1

High-throughput

0.500

High

555181

SKM1
Serine/threonine-protein kinase SKM1

1

2

High-throughput

0.500

High

430759

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

0

High-throughput

0.493

High

555184

COA3
Cytochrome c oxidase assembly factor 3, mitochondrial

1

0

High-throughput

0.493

High

555111

SAP4
SIT4-associating protein SAP4

1

0

High-throughput

0.486

High

448914

TOP2
DNA topoisomerase 2

1

0

High-throughput

0.479

High

449301

RAD3
General transcription and DNA repair factor IIH helicase subunit XPD/RAD3

1

0

High-throughput

0.479

High

554986

RAD50
DNA repair protein RAD50

1

0

High-throughput

0.479

High

554991

EI2BA
Translation initiation factor eIF2B subunit alpha

1

0

High-throughput

0.479

High

555003

FKBP
FK506-binding protein 1

1

0

High-throughput

0.479

High

555004

IF2A
Eukaryotic translation initiation factor 2 subunit alpha

1

0

High-throughput

0.479

High

555008

RAD53
Serine/threonine-protein kinase RAD53

1

0

High-throughput

0.479

High

555020

PDP2
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

1

0

High-throughput

0.479

High

555022

MSH1
DNA mismatch repair protein MSH1, mitochondrial

1

0

High-throughput

0.479

High

555028

HRR25
Casein kinase I homolog HRR25

1

0

High-throughput

0.479

High

555055

SHE2
SWI5-dependent HO expression protein 2

1

0

High-throughput

0.479

High

555063

IMB2
Importin subunit beta-2

1

0

High-throughput

0.479

High

555065

CS111
F-box protein COS111

1

0

High-throughput

0.479

High

555066

TYDP1
Tyrosyl-DNA phosphodiesterase 1

1

0

High-throughput

0.479

High

555082

AFG3
Mitochondrial inner membrane m-AAA protease component YTA10

1

0

High-throughput

0.479

High

555092

NTA1
Protein N-terminal amidase

1

0

High-throughput

0.479

High

555099

PSMD9
Probable 26S proteasome regulatory subunit p27

1

0

High-throughput

0.479

High

555104

LEM3
Phospholipid-transporting ATPase accessory subunit LEM3

1

0

High-throughput

0.479

High

555120

FPK1
Flippase kinase 1

1

0

High-throughput

0.479

High

555124

SIW14
Inositol diphosphatase SIW14

1

0

High-throughput

0.479

High

555128

RHO4
GTP-binding protein RHO4

1

0

High-throughput

0.479

High

555129

2ABA
Protein phosphatase PP2A regulatory subunit B

1

0

High-throughput

0.479

High

555137

IMA1
Importin subunit alpha

1

0

High-throughput

0.479

High

555158

OMS1
Methyltransferase OMS1, mitochondrial

1

0

High-throughput

0.479

High

555185

YPT6
GTP-binding protein YPT6

1

0

High-throughput

0.479

High

358947

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

2

High-throughput

0.479

High

359131

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

2

High-throughput

0.479

High

359416

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

2

High-throughput

0.479

High

367667

ENO1
Enolase 1

1

1

High-throughput

0.479

High

367873

ENO2
Enolase 2

1

1

High-throughput

0.479

High

392117

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.479

High

416354

HXKA
Hexokinase-1

1

1

High-throughput

0.479

High

416508

HXKB
Hexokinase-2

1

1

High-throughput

0.479

High

432469

RL7A
Large ribosomal subunit protein uL30A

1

1

High-throughput

0.479

High

555010

TKT1
Transketolase 1

1

1

High-throughput

0.479

High

555021

CDC48
Cell division control protein 48

1

1

High-throughput

0.479

High

555042

HSP7F
Heat shock protein homolog SSE1

1

3

High-throughput

0.479

High

555060

ATG8
Autophagy-related protein 8

1

2

High-throughput

0.479

High

555061

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

2

High-throughput

0.479

High

555135

ABF2
ARS-binding factor 2, mitochondrial

1

1

High-throughput

0.479

High

555155

PUR8
Adenylosuccinate lyase

1

1

High-throughput

0.479

High

361412

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.458

High

364895

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.458

High

365540

PGK
Phosphoglycerate kinase

1

0

High-throughput

0.458

High

368395

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.458

High

368568

PMG1
Phosphoglycerate mutase 1

1

0

High-throughput

0.458

High

401848

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.458

High

432278

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.458

High

434763

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

439214

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.458

High

450695

KAD2
Adenylate kinase

1

0

High-throughput

0.458

High

452552

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

0

High-throughput

0.458

High

454062

DHE4
NADP-specific glutamate dehydrogenase 1

1

0

High-throughput

0.458

High

481841

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

554988

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.458

High

554992

CYPH
Peptidyl-prolyl cis-trans isomerase

1

0

High-throughput

0.458

High

555005

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.458

High

555026

HIBCH
Small ribosomal subunit protein mS47

1

0

High-throughput

0.458

High

555031

HS104
Heat shock protein 104

1

0

High-throughput

0.458

High

555032

P5CR
Pyrroline-5-carboxylate reductase

1

0

High-throughput

0.458

High

555038

EF1B
Elongation factor 1-beta

1

0

High-throughput

0.458

High

555047

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

555054

TCTP
Translationally-controlled tumor protein homolog

1

0

High-throughput

0.458

High

555064

GID4
GID complex substrate-recognition subunit 4

1

0

High-throughput

0.458

High

555072

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.458

High

555073

CH10
10 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

555079

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.458

High

555085

SAHH
Adenosylhomocysteinase

1

0

High-throughput

0.458

High

555095

MLP2
Protein MLP2

1

0

High-throughput

0.458

High

555098

FIS1
Mitochondrial fission 1 protein

1

0

Small-scale

0.458

High

555106

DUG1
Cys-Gly metallodipeptidase DUG1

1

0

High-throughput

0.458

High

555117

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

555125

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.458

High

555126

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

0

High-throughput

0.458

High

555130

NUM1
Nuclear migration protein NUM1

1

0

High-throughput

0.458

High

555139

ESP1
Separin

1

0

High-throughput

0.458

High

555145

OYE2
NADPH dehydrogenase 2

1

0

High-throughput

0.458

High

555148

GIS1
Transcriptional activator/repressor GIS1

1

0

High-throughput

0.458

High

555162

ZEO1
Protein ZEO1

1

0

High-throughput

0.458

High

555167

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.458

High

555172

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.458

High

554989

KSS1
Mitogen-activated protein kinase KSS1

1

3

High-throughput

0.457

High

554996

PCNA
Proliferating cell nuclear antigen

1

1

High-throughput

0.457

High

555012

MEK1
Meiosis-specific serine/threonine-protein kinase MEK1

1

1

High-throughput

0.457

High

555017

DMC1
Meiotic recombination protein DMC1

1

1

High-throughput

0.457

High

555018

RAD51
DNA repair protein RAD51

1

1

High-throughput

0.457

High

555019

GID7
GID complex subunit 7

1

1

High-throughput

0.457

High

555033

KNS1
Dual specificity protein kinase KNS1

1

1

High-throughput

0.457

High

555034

ARP2
Actin-related protein 2

1

1

High-throughput

0.457

High

555043

PP12
Serine/threonine-protein phosphatase PP1-2

1

1

High-throughput

0.457

High

555044

RAD24
Checkpoint protein RAD24

1

1

High-throughput

0.457

High

555046

RAD54
DNA repair and recombination protein RAD54

1

2

High-throughput

0.457

High

555049

SWE1
Mitosis inhibitor protein kinase SWE1

1

2

High-throughput

0.457

High

555052

PPZ2
Serine/threonine-protein phosphatase PP-Z2

1

1

High-throughput

0.457

High

555056

HEL1
E3 ubiquitin-protein ligase HEL1

1

1

High-throughput

0.457

High

555067

MSG5
Tyrosine-protein phosphatase MSG5

1

2

High-throughput

0.457

High

555076

MET30
F-box protein MET30

1

1

High-throughput

0.457

High

555090

TBP6
Probable 26S proteasome subunit YTA6

1

2

High-throughput

0.457

High

555091

RAD26
DNA repair and recombination protein RAD26

1

1

High-throughput

0.457

High

555097

SDP1
Dual-specificity protein phosphatase SDP1

1

2

High-throughput

0.457

High

555103

BUB1
Spindle assembly checkpoint serine/threonine-protein kinase BUB1

1

1

High-throughput

0.457

High

555115

CDH1
APC/C activator protein CDH1

1

1

High-throughput

0.457

High

555123

IPI3
Pre-rRNA-processing protein IPI3

1

1

High-throughput

0.457

High

555131

CDC14
Tyrosine-protein phosphatase CDC14

1

1

High-throughput

0.457

High

555133

RU17
U1 small nuclear ribonucleoprotein 70 kDa homolog

1

1

High-throughput

0.457

High

555144

TDA1
Serine/threonine-protein kinase TDA1

1

1

High-throughput

0.457

High

555153

ERB1
Ribosome biogenesis protein ERB1

1

1

High-throughput

0.457

High

555156

UTP13
U3 small nucleolar RNA-associated protein 13

1

1

High-throughput

0.457

High

555168

CDC53
Cell division control protein 53

1

1

High-throughput

0.457

High

555169

RAD28
Radiation-sensitive protein 28

1

2

High-throughput

0.457

High

555174

YP150
Putative serine/threonine-protein kinase YPL150W

1

1

High-throughput

0.457

High

555175

YGK3
Glycogen synthase kinase-3 homolog YGK3

1

3

High-throughput

0.457

High

555177

PKH2
Serine/threonine-protein kinase PKH2

1

1

High-throughput

0.457

High

555083

SLN1
Osmosensing histidine protein kinase SLN1

1

1

High-throughput

0.445

High

555088

SSB2
Ribosome-associated molecular chaperone SSB2

1

2

High-throughput

0.445

High

555138

YP109
ABC1 family protein YPL109C, mitochondrial

1

1

High-throughput

0.445

High

555000

PDI
Protein disulfide-isomerase

1

1

High-throughput

0.437

High

555039

HOG1
Mitogen-activated protein kinase HOG1

1

1

High-throughput

0.437

High

555058

RDH54
DNA repair and recombination protein RDH54

1

2

High-throughput

0.437

High

555070

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.437

High

555101

RLP7
Ribosome biogenesis protein RLP7

1

1

High-throughput

0.437

High

555142

TOM1
E3 ubiquitin-protein ligase TOM1

1

2

High-throughput

0.437

High

555147

PRP42
U1 small nuclear ribonucleoprotein component PRP42

1

1

High-throughput

0.437

High

555150

RUVB1
RuvB-like protein 1

1

1

High-throughput

0.437

High

555165

NCBP2
Nuclear cap-binding protein subunit 2

1

1

High-throughput

0.437

High

555166

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

555179

DBP10
ATP-dependent RNA helicase DBP10

1

2

High-throughput

0.437

High

555180

RUVB2
RuvB-like protein 2

1

1

High-throughput

0.437

High

555183

CMR1
DNA damage-binding protein CMR1

1

1

High-throughput

0.437

High

555151

PDR15
ATP-dependent permease PDR15

1

1

High-throughput

0.407

High

554987

CAF20
Cap-associated protein CAF20

2

0

High-throughput

0.310

High

555080

SAW1
Single-strand annealing weakened protein 1

2

0

High-throughput

0.307

High

555100

DSN1
Kinetochore-associated protein DSN1

2

0

High-throughput

0.298

High

554999

SPO12
Sporulation-specific protein 12

1

0

High-throughput

0.279

Low

555040

VPP1
V-type proton ATPase subunit a, vacuolar isoform

1

0

High-throughput

0.279

Low

555075

GAA1
GPI transamidase component GAA1

1

0

High-throughput

0.279

Low

448120

HAP2
Transcriptional activator HAP2

1

0

High-throughput

0.261

Low

448353

RAD1
DNA repair protein RAD1

1

0

High-throughput

0.261

Low

449048

CALM
Calmodulin

1

0

High-throughput

0.261

Low

449273

RAD10
DNA repair protein RAD10

1

0

High-throughput

0.261

Low

458993

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.261

Low

466770

SWI5
Transcriptional factor SWI5

1

0

High-throughput

0.261

Low

550613

SIR4
Regulatory protein SIR4

1

0

High-throughput

0.261

Low

554990

RAD9
DNA repair protein RAD9

1

0

High-throughput

0.261

Low

554997

ABP1
Actin-binding protein

1

0

High-throughput

0.261

Low

554998

CDC23
Anaphase-promoting complex subunit CDC23

1

0

High-throughput

0.261

Low

555002

PRP6
Pre-mRNA-splicing factor 6

1

0

High-throughput

0.261

Low

555006

DBF2
Cell cycle protein kinase DBF2

1

0

High-throughput

0.261

Low

555013

GRR1
SCF E3 ubiquitin ligase complex F-box protein GRR1

1

0

High-throughput

0.261

Low

555015

CDC10
Cell division control protein 10

1

0

High-throughput

0.261

Low

555023

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

0

High-throughput

0.261

Low

555024

RFA3
Replication factor A protein 3

1

0

High-throughput

0.261

Low

555035

CDC3
Cell division control protein 3

1

0

High-throughput

0.261

Low

555036

HYM1
Protein HYM1

1

0

High-throughput

0.261

Low

555037

CDC12
Cell division control protein 12

1

0

High-throughput

0.261

Low

555045

ELM1
Serine/threonine-protein kinase ELM1

1

0

High-throughput

0.261

Low

555048

SUI1
Eukaryotic translation initiation factor eIF-1

1

0

High-throughput

0.261

Low

555051

XRS2
DNA repair protein XRS2

1

0

High-throughput

0.261

Low

555053

CBF3C
Centromere DNA-binding protein complex CBF3 subunit C

1

0

High-throughput

0.261

Low

555062

PLPHP
Pyridoxal phosphate homeostasis protein

1

0

High-throughput

0.261

Low

555089

SECU
Securin

1

0

High-throughput

0.261

Low

555094

UTP18
U3 small nucleolar RNA-associated protein 18

1

0

High-throughput

0.261

Low

555110

UBC11
Ubiquitin-conjugating enzyme E2-18 kDa

1

0

High-throughput

0.261

Low

555116

YG2A
Zinc finger protein YGR067C

1

0

High-throughput

0.261

Low

555122

LTO1
Protein LTO1

1

0

High-throughput

0.261

Low

555136

MEC3
DNA damage checkpoint control protein MEC3

1

0

High-throughput

0.261

Low

555141

ECM5
Protein ECM5

1

0

Small-scale

0.261

Low

555149

YD131
F-box protein YDR131C

1

0

High-throughput

0.261

Low

555152

KU80
ATP-dependent DNA helicase II subunit 2

1

0

High-throughput

0.261

Low

555154

SEN15
tRNA-splicing endonuclease subunit SEN15

1

0

High-throughput

0.261

Low

555157

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

0

High-throughput

0.261

Low

555159

PRP11
Pre-mRNA-splicing factor PRP11

1

0

High-throughput

0.261

Low

555161

NOP6
Nucleolar protein 6

1

0

High-throughput

0.261

Low

555164

SOG2
Leucine-rich repeat-containing protein SOG2

1

0

High-throughput

0.261

Low

555171

MLH3
DNA mismatch repair protein MLH3

1

0

High-throughput

0.261

Low

555182

AIR2
Protein AIR2

1

0

High-throughput

0.261

Low

361958

HIS1
ATP phosphoribosyltransferase

1

0

High-throughput

0.249

Low

444409

DED1
ATP-dependent RNA helicase DED1

1

0

High-throughput

0.249

Low

554993

TAL1
Transaldolase

1

0

High-throughput

0.249

Low

554995

STI1
Heat shock protein STI1

1

0

High-throughput

0.249

Low

555025

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.249

Low

555027

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

555030

DHOM
Homoserine dehydrogenase

1

0

High-throughput

0.249

Low

555050

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.249

Low

555057

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.249

Low

555059

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

555068

YGP1
Protein YGP1

1

0

High-throughput

0.249

Low

555074

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

0

Small-scale

0.249

Low

555077

DHH1
ATP-dependent RNA helicase DHH1

1

0

High-throughput

0.249

Low

555086

SLX8
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8

1

0

High-throughput

0.249

Low

555087

YEY6
MYG1 protein YER156C

1

0

Small-scale

0.249

Low

555096

TM108
Protein TMA108

1

0

High-throughput

0.249

Low

555102

GPP1
Glycerol-1-phosphate phosphohydrolase 1

1

0

High-throughput

0.249

Low

555107

RIR4
Ribonucleoside-diphosphate reductase small chain 2

1

0

High-throughput

0.249

Low

555108

SKP1
Suppressor of kinetochore protein 1

1

0

Small-scale

0.249

Low

555113

VID30
GID complex subunit 1

1

0

High-throughput

0.249

Low

555118

HST2
NAD-dependent protein deacetylase HST2

1

0

High-throughput

0.249

Low

555127

ACT
Actin

1

0

Small-scale

0.249

Low

555160

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

555163

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

555173

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.249

Low

555176

RLM1
Transcription factor RLM1

1

0

High-throughput

0.249

Low

419570

H2A2
Histone H2A.2

1

0

High-throughput

0.232

Low

554389

HMDH2
3-hydroxy-3-methylglutaryl-coenzyme A reductase 2

1

0

High-throughput

0.232

Low

555071

BRL1
Nucleus export protein BRL1

1

0

High-throughput

0.232

Low

555078

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.232

Low

555093

PSF2
DNA replication complex GINS protein PSF2

1

0

High-throughput

0.232

Low

555119

ALG12
Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase

1

0

High-throughput

0.232

Low

555146

YMB8
Uncharacterized vacuolar membrane protein YML018C

1

0

High-throughput

0.232

Low

555178

HSP42
Heat shock protein 42

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025