Protein: THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20 (EC 2.7.1.49) (EC 2.7.4.7) (EC 3.5.99.2) (Hydroxymethylpyrimidine kinase) (HMP kinase) (Hydroxymethylpyrimidine phosphate kinase) (HMP-P kinase) (HMP-phosphate kinase) (HMPP kinase)

Gene: THI20
Organism: Saccharomyces cerevisiae S288C
Interactions: 112
UniProt ID: Q08224

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0008902 - hydroxymethylpyrimidine kinase activity
GO:0008972 - phosphomethylpyrimidine kinase activity
GO:0009228 - thiamine biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

440977

CDC7
Cell division control protein 7

1

1

High-throughput

0.500

High

448595

RHO2
GTP-binding protein RHO2

1

1

High-throughput

0.500

High

449367

RAD3
General transcription and DNA repair factor IIH helicase subunit XPD/RAD3

1

1

High-throughput

0.500

High

533197

GPA2
Guanine nucleotide-binding protein alpha-2 subunit

1

1

High-throughput

0.500

High

574611

YAK1
Dual specificity protein kinase YAK1

1

2

High-throughput

0.500

High

574747

KSS1
Mitogen-activated protein kinase KSS1

1

1

High-throughput

0.500

High

645985

DBF2
Cell cycle protein kinase DBF2

1

2

High-throughput

0.500

High

656649

KC11
Casein kinase I homolog 1

1

3

High-throughput

0.500

High

671495

RAD57
DNA repair protein RAD57

1

1

High-throughput

0.500

High

735280

KNS1
Dual specificity protein kinase KNS1

1

2

High-throughput

0.500

High

740622

IME2
Meiosis induction protein kinase IME2/SME1

1

1

High-throughput

0.500

High

744215

RAD24
Checkpoint protein RAD24

1

1

High-throughput

0.500

High

746353

RAD54
DNA repair and recombination protein RAD54

1

3

High-throughput

0.500

High

750902

PRS6B
26S proteasome regulatory subunit 6B homolog

1

1

High-throughput

0.500

High

802916

DBP8
ATP-dependent RNA helicase DBP8

1

2

High-throughput

0.500

High

807648

MLH1
DNA mismatch repair protein MLH1

1

1

High-throughput

0.500

High

815592

RSP5
E3 ubiquitin-protein ligase RSP5

1

1

High-throughput

0.500

High

823199

RAD26
DNA repair and recombination protein RAD26

1

3

High-throughput

0.500

High

825435

PRK1
Actin-regulating kinase PRK1

1

1

High-throughput

0.500

High

912390

UBC13
Ubiquitin-conjugating enzyme E2 13

1

2

High-throughput

0.500

High

912400

UBC11
Ubiquitin-conjugating enzyme E2-18 kDa

1

2

High-throughput

0.500

High

922179

PAP2
Poly(A) RNA polymerase protein 2

1

1

High-throughput

0.500

High

1027290

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

1

High-throughput

0.500

High

1043333

TDA1
Serine/threonine-protein kinase TDA1

1

1

High-throughput

0.500

High

1062757

YP150
Putative serine/threonine-protein kinase YPL150W

1

3

High-throughput

0.500

High

1062761

SMC6
Structural maintenance of chromosomes protein 6

1

1

High-throughput

0.500

High

416834

DNLI1
DNA ligase 1

1

0

High-throughput

0.479

High

585736

UBC4
Ubiquitin-conjugating enzyme E2 4

1

0

High-throughput

0.479

High

646552

RAD53
Serine/threonine-protein kinase RAD53

1

0

High-throughput

0.479

High

672355

RV161
Reduced viability upon starvation protein 161

1

0

High-throughput

0.479

High

738049

MKK1
MAP kinase kinase MKK1/SSP32

1

0

High-throughput

0.479

High

798002

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.479

High

800977

RFC3
Replication factor C subunit 3

1

0

High-throughput

0.479

High

808609

SMC2
Structural maintenance of chromosomes protein 2

1

0

High-throughput

0.479

High

811606

PEX7
Peroxisomal targeting signal 2 receptor

1

0

High-throughput

0.479

High

815803

GDI1
Rab GDP-dissociation inhibitor

1

0

High-throughput

0.479

High

825837

YRB2
Ran-specific GTPase-activating protein 2

1

0

High-throughput

0.479

High

850976

TOS3
Serine/threonine-protein kinase TOS3

1

0

High-throughput

0.479

High

916999

BOL2
BolA-like protein 2

1

0

High-throughput

0.479

High

1046627

KU80
ATP-dependent DNA helicase II subunit 2

1

0

High-throughput

0.479

High

1062758

GET3
ATPase GET3

1

0

High-throughput

0.479

High

1062760

PKH2
Serine/threonine-protein kinase PKH2

1

0

High-throughput

0.479

High

1062762

YPT6
GTP-binding protein YPT6

1

0

High-throughput

0.479

High

671191

SIS1
Protein SIS1

1

1

High-throughput

0.479

High

680116

CDC48
Cell division control protein 48

1

1

High-throughput

0.479

High

795567

ATG8
Autophagy-related protein 8

1

4

High-throughput

0.479

High

1062755

MLH3
DNA mismatch repair protein MLH3

1

1

High-throughput

0.479

High

745900

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.458

High

763299

SGS1
ATP-dependent helicase SGS1

1

0

High-throughput

0.458

High

1046188

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.458

High

448476

RAD52
DNA repair and recombination protein RAD52

1

1

High-throughput

0.457

High

459174

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

1

High-throughput

0.457

High

550700

SIR4
Regulatory protein SIR4

1

1

High-throughput

0.457

High

688827

RFA3
Replication factor A protein 3

1

1

High-throughput

0.457

High

702287

YJU2
Splicing factor YJU2

1

1

High-throughput

0.457

High

734867

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

2

High-throughput

0.457

High

781501

HEL1
E3 ubiquitin-protein ligase HEL1

1

1

High-throughput

0.457

High

800441

MSG5
Tyrosine-protein phosphatase MSG5

1

1

High-throughput

0.457

High

808561

TEM1
Protein TEM1

1

2

High-throughput

0.457

High

1026842

CDC14
Tyrosine-protein phosphatase CDC14

1

1

High-throughput

0.457

High

1037853

MEC3
DNA damage checkpoint control protein MEC3

1

1

High-throughput

0.457

High

1044284

YD131
F-box protein YDR131C

1

1

High-throughput

0.457

High

1056382

OMS1
Methyltransferase OMS1, mitochondrial

1

2

High-throughput

0.457

High

1059210

PRP11
Pre-mRNA-splicing factor PRP11

1

2

High-throughput

0.457

High

1062750

DIA2
Protein DIA2

1

1

High-throughput

0.457

High

1062752

CDC53
Cell division control protein 53

1

3

High-throughput

0.457

High

1062753

RAD28
Radiation-sensitive protein 28

1

1

High-throughput

0.457

High

1062759

PSH1
RING finger protein PSH1

1

1

High-throughput

0.457

High

525364

HSP71
Heat shock protein SSA1

1

4

High-throughput

0.445

High

742545

HSP7F
Heat shock protein homolog SSE1

1

6

High-throughput

0.445

High

1046590

PANK
Pantothenate kinase CAB1

1

0

High-throughput

0.438

High

708376

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

708794

TF3B
Transcription factor IIIB 70 kDa subunit

1

3

High-throughput

0.437

High

421282

PHR
Deoxyribodipyrimidine photo-lyase, mitochondrial

1

0

High-throughput

0.261

Low

448232

HAP2
Transcriptional activator HAP2

1

0

High-throughput

0.261

Low

448412

RAD1
DNA repair protein RAD1

1

0

High-throughput

0.261

Low

449290

RAD10
DNA repair protein RAD10

1

0

High-throughput

0.261

Low

466806

SWI5
Transcriptional factor SWI5

1

0

High-throughput

0.261

Low

558884

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.261

Low

575291

RAD9
DNA repair protein RAD9

1

0

High-throughput

0.261

Low

586491

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.261

Low

633274

CKS1
Cyclin-dependent kinases regulatory subunit

1

0

High-throughput

0.261

Low

666712

GRR1
SCF E3 ubiquitin ligase complex F-box protein GRR1

1

0

High-throughput

0.261

Low

678793

PDP2
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

1

0

High-throughput

0.261

Low

737345

CDC12
Cell division control protein 12

1

0

High-throughput

0.261

Low

743300

PP12
Serine/threonine-protein phosphatase PP1-2

1

0

High-throughput

0.261

Low

751055

XRS2
DNA repair protein XRS2

1

0

High-throughput

0.261

Low

794009

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

0

High-throughput

0.261

Low

795738

PLPHP
Pyridoxal phosphate homeostasis protein

1

0

High-throughput

0.261

Low

798027

TYDP1
Tyrosyl-DNA phosphodiesterase 1

1

0

High-throughput

0.261

Low

805580

SET1
Histone-lysine N-methyltransferase, H3 lysine-4 specific

1

0

High-throughput

0.261

Low

806589

UTP9
U3 small nucleolar RNA-associated protein 9

1

0

High-throughput

0.261

Low

823401

UTP18
U3 small nucleolar RNA-associated protein 18

1

0

High-throughput

0.261

Low

843151

LEM3
Phospholipid-transporting ATPase accessory subunit LEM3

1

0

High-throughput

0.261

Low

858327

NUP85
Nucleoporin NUP85

1

0

High-throughput

0.261

Low

864757

BBC1
Myosin tail region-interacting protein MTI1

1

0

High-throughput

0.261

Low

910796

SKP1
Suppressor of kinetochore protein 1

1

0

High-throughput

0.261

Low

918124

CDH1
APC/C activator protein CDH1

1

0

High-throughput

0.261

Low

919405

RBG2
Ribosome-interacting GTPase 2

1

0

High-throughput

0.261

Low

1040604

COFI
Cofilin

1

0

High-throughput

0.261

Low

1044961

POLH
DNA polymerase eta

1

0

High-throughput

0.261

Low

1047347

SEN15
tRNA-splicing endonuclease subunit SEN15

1

0

High-throughput

0.261

Low

1054548

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

0

High-throughput

0.261

Low

1055153

MAG2
E3 ubiquitin-protein ligase MAG2

1

0

High-throughput

0.261

Low

1062751

DDC1
DNA damage checkpoint protein 1

1

0

High-throughput

0.261

Low

647237

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.249

Low

747708

ATO2
Ammonia transport outward protein 2

1

0

High-throughput

0.249

Low

814745

EXO1
Exodeoxyribonuclease 1

1

0

High-throughput

0.249

Low

826097

ULP2
Ubiquitin-like-specific protease 2

1

0

Small-scale

0.249

Low

1054858

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

1062754

HFI1
SAGA complex subunit HFI1

1

0

Small-scale

0.249

Low

1062756

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025