Protein: GCH1
GTP cyclohydrolase 1 (EC 3.5.4.16) (GTP cyclohydrolase I) (GTP-CH-I)

Gene: GCH1, FOL2
Organism: Saccharomyces cerevisiae S288C
Interactions: 48
UniProt ID: P51601

Gene Ontology (top 5):
GO:0003934 - GTP cyclohydrolase I activity
GO:0005525 - GTP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0006729 - tetrahydrobiopterin biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

847970

GCH1
GTP cyclohydrolase 1

1

7

High-throughput

0.656

High

366592

HSP82
ATP-dependent molecular chaperone HSP82

3

0

High-throughput

0.606

High

847974

IMA1
Importin subunit alpha

2

0

High-throughput

0.594

High

491828

HSP71
Heat shock protein SSA1

2

3

High-throughput

0.584

High

768923

SSB2
Ribosome-associated molecular chaperone SSB2

2

3

High-throughput

0.552

High

628266

SIS1
Protein SIS1

2

0

High-throughput

0.547

High

511993

SSB1
Ribosome-associated molecular chaperone SSB1

1

3

High-throughput

0.536

High

614726

KC11
Casein kinase I homolog 1

1

1

High-throughput

0.536

High

419361

HAP2
Transcriptional activator HAP2

1

0

High-throughput

0.513

High

608713

UBA1
Ubiquitin-activating enzyme E1 1

1

0

High-throughput

0.513

High

624306

GRR1
SCF E3 ubiquitin ligase complex F-box protein GRR1

1

0

High-throughput

0.513

High

758942

LYS1
Saccharopine dehydrogenase [NAD(+), L-lysine-forming]

1

0

High-throughput

0.513

High

847973

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

0

High-throughput

0.513

High

847983

DUF1
DUB-associated factor 1

1

0

High-throughput

0.513

High

687970

IMB3
Importin subunit beta-3

1

1

High-throughput

0.508

High

477371

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

1

High-throughput

0.501

High

847972

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.493

High

748843

NTM1
Alpha N-terminal protein methyltransferase 1

1

0

High-throughput

0.486

High

847981

USB1
U6 snRNA phosphodiesterase 1

1

0

High-throughput

0.486

High

412810

KAPA
cAMP-dependent protein kinase type 1

1

0

High-throughput

0.480

High

539265

YAK1
Dual specificity protein kinase YAK1

1

0

High-throughput

0.480

High

811878

PTK2
Serine/threonine-protein kinase PTK2/STK2

1

0

High-throughput

0.480

High

402987

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

0

High-throughput

0.458

High

558152

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

662763

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

700990

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

768382

YRF12
Y' element ATP-dependent helicase protein 1 copy 2

1

0

High-throughput

0.458

High

770047

RIO2
Serine/threonine-protein kinase RIO2

1

0

High-throughput

0.458

High

770299

CCS1
Superoxide dismutase 1 copper chaperone

1

0

High-throughput

0.458

High

847975

RUVB1
RuvB-like protein 1

1

0

High-throughput

0.458

High

847976

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

847978

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

847980

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

450112

HSP73
Heat shock protein SSA3

1

3

High-throughput

0.445

High

494441

HSP72
Heat shock protein SSA2

1

3

High-throughput

0.445

High

695091

HSP7F
Heat shock protein homolog SSE1

1

4

High-throughput

0.445

High

755062

PP2C7
Protein phosphatase 2C homolog 7, mitochondrial

1

1

High-throughput

0.437

High

847982

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

1

High-throughput

0.437

High

757182

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

0

High-throughput

0.426

High

792388

TCPH
T-complex protein 1 subunit eta

1

0

High-throughput

0.426

High

847977

KU80
ATP-dependent DNA helicase II subunit 2

1

0

High-throughput

0.279

Low

691828

EI2BB
Translation initiation factor eIF2B subunit beta

1

0

High-throughput

0.265

Low

847971

PDK2
[Pyruvate dehydrogenase

1

0

High-throughput

0.261

Low

745768

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

762186

ATC3
Phospholipid-transporting ATPase DRS2

1

0

High-throughput

0.249

Low

762383

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

847979

YP251
Putative uncharacterized protein YPL251W

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024