Protein: HLDD
ADP-L-glycero-D-manno-heptose-6-epimerase (EC 5.1.3.20) (ADP-L-glycero-beta-D-manno-heptose-6-epimerase) (ADP-glyceromanno-heptose 6-epimerase) (ADP-hep 6-epimerase) (AGME)

Gene: HLDD
Organism: Escherichia coli K-12
Interactions: 67
UniProt ID: P67910

Gene Ontology (top 5):
GO:0005829 - cytosol
GO:0008712 - ADP-glyceromanno-heptose 6-epimerase activity
GO:0009244 - lipopolysaccharide core region biosynthetic process
GO:0016020 - membrane
GO:0070401 - NADP+ binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

995395

HLDD
ADP-L-glycero-D-manno-heptose-6-epimerase

1

12

High-throughput

0.618

High

498622

MENB
1,4-dihydroxy-2-naphthoyl-CoA synthase

2

0

High-throughput

0.585

High

597643

ICLR
Transcriptional repressor IclR

2

0

High-throughput

0.585

High

492651

RL19
Large ribosomal subunit protein bL19

2

0

High-throughput

0.563

High

498606

DPS
DNA protection during starvation protein

2

0

High-throughput

0.563

High

506710

RNPH
Truncated inactive ribonuclease PH

2

0

High-throughput

0.563

High

995398

FADI
3-ketoacyl-CoA thiolase FadI

2

0

High-throughput

0.563

High

750370

AIDB
Putative acyl-CoA dehydrogenase AidB

2

1

High-throughput

0.537

High

489927

CH60
Chaperonin GroEL

1

2

High-throughput

0.515

High

479553

NARG
Respiratory nitrate reductase 1 alpha chain

1

1

High-throughput

0.484

High

490190

CH10
Co-chaperonin GroES

1

1

High-throughput

0.484

High

490277

CLPP
ATP-dependent Clp protease proteolytic subunit

1

3

High-throughput

0.484

High

491246

DNAK
Chaperone protein DnaK

1

1

High-throughput

0.484

High

639470

LPXD
UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase

1

3

High-throughput

0.484

High

995399

DDPD
Probable D,D-dipeptide transport ATP-binding protein DdpD

1

2

High-throughput

0.484

High

994116

YQJI
Transcriptional regulator YqjI

1

0

High-throughput

0.479

High

495672

SYK2
Lysine--tRNA ligase, heat inducible

1

1

High-throughput

0.479

High

499785

YGAM
Uncharacterized protein YgaM

1

1

High-throughput

0.479

High

499988

YAJC
Sec translocon accessory complex subunit YajC

1

1

High-throughput

0.479

High

500114

YOAB
RutC family protein YoaB

1

1

High-throughput

0.479

High

645664

MURE
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase

1

1

High-throughput

0.479

High

382750

RS7
Small ribosomal subunit protein uS7

1

0

High-throughput

0.464

High

491562

KDSA
2-dehydro-3-deoxyphosphooctonate aldolase

1

0

High-throughput

0.464

High

492085

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.464

High

499712

YHHN
Uncharacterized membrane protein YhhN

1

0

High-throughput

0.464

High

543359

ENTF
Enterobactin synthase component F

1

0

High-throughput

0.464

High

951030

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.464

High

963256

RISB
6,7-dimethyl-8-ribityllumazine synthase

1

0

High-throughput

0.464

High

486854

GLTD
Glutamate synthase [NADPH] small chain

1

0

High-throughput

0.458

High

495592

TMAR
Pole-localizer protein TmaR

1

0

High-throughput

0.458

High

496741

PHOL
PhoH-like protein

1

0

High-throughput

0.458

High

498363

CISY
Citrate synthase

1

0

High-throughput

0.458

High

498658

EXBB
Biopolymer transport protein ExbB

1

0

High-throughput

0.458

High

498740

KDSC
3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC

1

0

High-throughput

0.458

High

500836

OPPB
Oligopeptide transport system permease protein OppB

1

0

High-throughput

0.458

High

500980

RISA
Riboflavin synthase

1

0

High-throughput

0.458

High

788380

RLMN
Dual-specificity RNA methyltransferase RlmN

1

0

High-throughput

0.458

High

497211

FTSE
Cell division ATP-binding protein FtsE

1

1

High-throughput

0.442

High

499369

CRA
Catabolite repressor/activator

1

1

High-throughput

0.442

High

750376

TORA
Trimethylamine-N-oxide reductase 1

1

1

High-throughput

0.442

High

994114

YQJD
Uncharacterized protein YqjD

1

1

High-throughput

0.437

High

495225

YBJQ
UPF0145 protein YbjQ

2

0

High-throughput

0.318

High

676582

UBIH
2-octaprenyl-6-methoxyphenol hydroxylase

2

0

High-throughput

0.318

High

976950

ISPF
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

2

0

High-throughput

0.318

High

750386

LLDD
L-lactate dehydrogenase

2

0

High-throughput

0.307

High

994077

YDIH
Uncharacterized protein YdiH

2

0

High-throughput

0.307

High

360237

NDH
Type II NADH:quinone oxidoreductase

1

0

High-throughput

0.279

Low

509973

HCAB
3-phenylpropionate-dihydrodiol/cinnamic acid-dihydrodiol dehydrogenase

1

0

High-throughput

0.279

Low

384059

RL15
Large ribosomal subunit protein uL15

1

0

High-throughput

0.253

Low

521498

SECA
Protein translocase subunit SecA

1

0

High-throughput

0.253

Low

598640

CYSM
Cysteine synthase B

1

0

High-throughput

0.253

Low

790794

BCSE
Cyclic di-GMP binding protein BcsE

1

0

High-throughput

0.253

Low

811707

USPG
Universal stress protein UP12

1

0

High-throughput

0.253

Low

995396

YBJX
Uncharacterized protein YbjX

1

0

High-throughput

0.253

Low

995397

YDAY
Protein YdaY

1

0

High-throughput

0.253

Low

490376

COAD
Phosphopantetheine adenylyltransferase

1

0

High-throughput

0.249

Low

496171

RIMI
[Ribosomal protein bS18]-alanine N-acetyltransferase

1

0

High-throughput

0.249

Low

497944

FRMR
Transcriptional repressor FrmR

1

0

High-throughput

0.249

Low

499815

YGGE
Uncharacterized protein YggE

1

0

High-throughput

0.249

Low

716090

LHR
Lhr helicase/uracil glycosylase

1

0

High-throughput

0.249

Low

786974

YADG
Uncharacterized ABC transporter ATP-binding protein YadG

1

0

High-throughput

0.249

Low

909903

YAER
Uncharacterized protein YaeR

1

0

High-throughput

0.249

Low

960970

LOLB
Outer-membrane lipoprotein LolB

1

0

High-throughput

0.249

Low

995400

GTRB
Prophage bactoprenol glucosyl transferase homolog

1

0

High-throughput

0.249

Low

995401

MAA
Maltose O-acetyltransferase

1

0

High-throughput

0.249

Low

995402

UACT
Uric acid transporter UacT

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025