Protein: PYRE
Orotate phosphoribosyltransferase 1 (OPRT 1) (OPRTase 1) (EC 2.4.2.10)

Gene: PYRE, URA5
Organism: Saccharomyces cerevisiae S288C
Interactions: 25
UniProt ID: P13298

Gene Ontology (top 5):
GO:0004588 - orotate phosphoribosyltransferase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0006207 - 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 - pyrimidine nucleotide biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

561185

PYRX
Orotate phosphoribosyltransferase 2

2

15

High-throughput

0.776

High

561179

PYRE
Orotate phosphoribosyltransferase 1

1

14

High-throughput

0.656

High

561195

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

1

High-throughput

0.584

High

543644

SSB1
Ribosome-associated molecular chaperone SSB1

2

3

High-throughput

0.552

High

561183

PPZ1
Serine/threonine-protein phosphatase PP-Z1

1

0

High-throughput

0.518

High

547751

NHP6A
Non-histone chromosomal protein 6A

1

0

High-throughput

0.493

High

561190

NTR2
Pre-mRNA-splicing factor NTR2

1

0

High-throughput

0.493

High

561194

6P21
6-phosphofructo-2-kinase 1

1

0

High-throughput

0.493

High

561180

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.479

High

561184

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

561188

PRS6A
26S proteasome regulatory subunit 6A

1

1

High-throughput

0.479

High

561191

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.479

High

561196

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

1

High-throughput

0.479

High

561186

EI2BB
Translation initiation factor eIF2B subunit beta

1

1

High-throughput

0.464

High

561181

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

561182

SIS1
Protein SIS1

1

0

High-throughput

0.458

High

561187

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

0

High-throughput

0.458

High

561189

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.458

High

561192

NACA
Nascent polypeptide-associated complex subunit alpha

1

0

High-throughput

0.458

High

561193

SSB2
Ribosome-associated molecular chaperone SSB2

1

3

High-throughput

0.445

High

522895

HSP71
Heat shock protein SSA1

1

0

High-throughput

0.426

High

561199

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

2

High-throughput

0.407

High

561197

TGL2
Triacylglycerol lipase 2

1

0

High-throughput

0.269

Low

561198

ACAC
Acetyl-CoA carboxylase

1

0

Small-scale

0.251

Low


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Last updated: 11Aug2025