Protein: NACA
Nascent polypeptide-associated complex subunit alpha (NAC-alpha) (Alpha-NAC) (GAL4 DNA-binding enhancer protein 2)

Gene: NACA, EGD2
Organism: Saccharomyces cerevisiae S288C
Interactions: 129
UniProt ID: P38879

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005854 - nascent polypeptide-associated complex
GO:0006612 - protein targeting to membrane
GO:0006613 - cotranslational protein targeting to membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

806493

NACB1
Nascent polypeptide-associated complex subunit beta-1

12

20

Small-scale

0.980

High

806464

NACB2
Nascent polypeptide-associated complex subunit beta-2

3

20

Small-scale

0.845

High

806453

NACA
Nascent polypeptide-associated complex subunit alpha

1

4

Small-scale

0.621

High

570012

RL3
Large ribosomal subunit protein uL3

3

0

High-throughput

0.606

High

806508

SMT3
Ubiquitin-like protein SMT3

2

3

High-throughput

0.600

High

531734

RL4A
Large ribosomal subunit protein uL4A

2

1

Small-scale

0.585

High

806472

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

1

High-throughput

0.584

High

427271

RLA0
Large ribosomal subunit protein uL10

2

1

High-throughput

0.571

High

790246

GLYM
Serine hydroxymethyltransferase, mitochondrial

2

1

High-throughput

0.571

High

806481

CF130
Protein CAF130

2

0

High-throughput

0.563

High

806505

TMA46
Translation machinery-associated protein 46

2

0

High-throughput

0.559

High

523911

HSP71
Heat shock protein SSA1

2

2

High-throughput

0.552

High

526665

HSP72
Heat shock protein SSA2

2

2

High-throughput

0.552

High

544835

SSB1
Ribosome-associated molecular chaperone SSB1

2

2

High-throughput

0.552

High

666454

DBP2
ATP-dependent RNA helicase DBP2

2

0

High-throughput

0.547

High

709378

HRR25
Casein kinase I homolog HRR25

1

1

High-throughput

0.536

High

734307

DBF20
Serine/threonine-protein kinase DBF20

1

1

High-throughput

0.536

High

806489

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

2

High-throughput

0.536

High

806497

ERB1
Ribosome biogenesis protein ERB1

1

1

High-throughput

0.536

High

515255

RL35A
Large ribosomal subunit protein uL29A

2

1

Small-scale

0.533

High

482013

C1TM
C-1-tetrahydrofolate synthase, mitochondrial

2

1

High-throughput

0.521

High

806471

BUD27
Bud site selection protein 27

1

0

Small-scale

0.518

High

419731

H2A2
Histone H2A.2

1

1

High-throughput

0.515

High

518016

SSBP1
Single-stranded nucleic acid-binding protein

1

1

High-throughput

0.515

High

806496

HMO1
High mobility group protein 1

1

1

High-throughput

0.515

High

806507

YRA1
RNA annealing protein YRA1

1

1

High-throughput

0.515

High

585706

UBC4
Ubiquitin-conjugating enzyme E2 4

1

1

Small-scale

0.508

High

585750

UBC5
Ubiquitin-conjugating enzyme E2-16 kDa

1

1

Small-scale

0.508

High

806459

RSP5
E3 ubiquitin-protein ligase RSP5

1

4

Small-scale

0.501

High

448964

TOP2
DNA topoisomerase 2

1

0

High-throughput

0.493

High

806456

POP2
Poly(A) ribonuclease POP2

1

0

High-throughput

0.493

High

806462

SIP5
Protein SIP5

1

0

High-throughput

0.493

High

806485

SYC
Cysteine--tRNA ligase

1

0

High-throughput

0.493

High

806509

SPSY
Spermine synthase SPE4

1

0

High-throughput

0.486

High

806466

ULP2
Ubiquitin-like-specific protease 2

1

1

High-throughput

0.481

High

806494

ULP1
Ubiquitin-like-specific protease 1

1

1

High-throughput

0.481

High

806510

CMR1
DNA damage-binding protein CMR1

1

2

High-throughput

0.481

High

438688

SC160
Protein SCP160

1

3

High-throughput

0.479

High

509547

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

3

Small-scale

0.479

High

579365

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.479

High

646397

RAD53
Serine/threonine-protein kinase RAD53

1

2

High-throughput

0.479

High

679661

CDC48
Cell division control protein 48

1

1

High-throughput

0.479

High

778324

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.479

High

806490

NOP3
Serine/arginine

1

1

High-throughput

0.479

High

806492

ABF2
ARS-binding factor 2, mitochondrial

1

1

High-throughput

0.479

High

806495

TOM1
E3 ubiquitin-protein ligase TOM1

1

4

High-throughput

0.479

High

806504

YP225
Protein PBDC1 homolog

1

2

Small-scale

0.479

High

806479

SAM37
Sorting assembly machinery 37 kDa subunit

1

0

Small-scale

0.460

High

514633

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

531325

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.458

High

561192

PYRE
Orotate phosphoribosyltransferase 1

1

0

High-throughput

0.458

High

670691

SIS1
Protein SIS1

1

0

High-throughput

0.458

High

674617

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

707064

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

734972

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

745730

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.458

High

801717

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.458

High

803113

ECM29
Proteasome component ECM29

1

0

High-throughput

0.458

High

803534

RPN1
26S proteasome regulatory subunit RPN1

1

0

Small-scale

0.458

High

806454

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.458

High

806455

BFR1
Nuclear segregation protein BFR1

1

0

High-throughput

0.458

High

806458

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.458

High

806465

TM108
Protein TMA108

1

0

High-throughput

0.458

High

806467

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

806475

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

806480

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

806482

H1
Histone H1

1

0

High-throughput

0.458

High

806483

TR112
Multifunctional methyltransferase subunit TRM112

1

0

Small-scale

0.458

High

806491

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

806500

HEL2
E3 ubiquitin-protein ligase HEL2

1

0

High-throughput

0.458

High

806501

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

403506

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

1

High-throughput

0.445

High

432576

RL7A
Large ribosomal subunit protein uL30A

1

1

High-throughput

0.445

High

433203

RL17A
Large ribosomal subunit protein uL22A

1

1

Small-scale

0.445

High

741558

HSP7F
Heat shock protein homolog SSE1

1

5

High-throughput

0.445

High

792038

GBLP
Small ribosomal subunit protein RACK1

1

1

High-throughput

0.445

High

806461

SSB2
Ribosome-associated molecular chaperone SSB2

1

2

High-throughput

0.445

High

806469

RL10
Large ribosomal subunit protein uL16

1

2

High-throughput

0.445

High

806477

RL4B
Large ribosomal subunit protein uL4B

1

1

High-throughput

0.445

High

577129

SEC63
Protein translocation protein SEC63

1

1

Small-scale

0.439

High

434566

RL22A
Large ribosomal subunit protein eL22A

1

1

High-throughput

0.437

High

455057

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.437

High

504206

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

689447

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.437

High

785922

LONM
Lon protease homolog, mitochondrial

1

2

High-throughput

0.437

High

806468

RLP7
Ribosome biogenesis protein RLP7

1

1

High-throughput

0.437

High

806488

RL22B
Large ribosomal subunit protein eL22B

1

1

High-throughput

0.437

High

806502

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.437

High

394547

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

435082

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.426

High

435958

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.426

High

609056

SKI3
Superkiller protein 3

1

0

High-throughput

0.426

High

684721

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.426

High

688883

RS5
Small ribosomal subunit protein uS7

1

0

High-throughput

0.426

High

743024

SWI3
SWI/SNF complex subunit SWI3

1

0

High-throughput

0.426

High

806460

PFD2
Prefoldin subunit 2

1

0

High-throughput

0.426

High

806478

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

0

High-throughput

0.426

High

806484

CAF40
Protein CAF40

1

0

Small-scale

0.426

High

806499

RQC1
Ribosome quality control complex subunit 1

1

0

Small-scale

0.426

High

806473

RL17B
Large ribosomal subunit protein uL22B

1

1

High-throughput

0.407

High

806476

RS7B
Small ribosomal subunit protein eS7B

1

1

High-throughput

0.407

High

631919

SRP54
Signal recognition particle subunit SRP54

3

0

Small-scale

0.337

High

798091

OM14
Mitochondrial outer membrane protein OM14

2

0

Small-scale

0.323

High

753363

RS3A1
Small ribosomal subunit protein eS1A

2

0

High-throughput

0.298

High

618869

GAP1
General amino-acid permease GAP1

1

0

Small-scale

0.288

High

806487

SLG1
Protein SLG1

1

0

Small-scale

0.288

High

758003

PXA2
Peroxisomal long-chain fatty acid import protein 1

1

0

High-throughput

0.282

High

806457

YCFI
Metal resistance protein YCF1

1

0

High-throughput

0.282

High

782330

RPF2
Ribosome biogenesis protein RPF2

1

0

High-throughput

0.269

Low

806474

YJY1
Uncharacterized protein YJR011C

1

0

High-throughput

0.269

Low

806498

GLU2B
Glucosidase 2 subunit beta

1

0

High-throughput

0.269

Low

94557

STE2
Pheromone alpha factor receptor

1

0

High-throughput

0.251

Low

779851

MID2
Cell wall integrity sensor MID2

1

0

Small-scale

0.251

Low

383125

RLA4
Large ribosomal subunit protein P2B

1

0

High-throughput

0.249

Low

410125

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

434019

RL33A
Large ribosomal subunit protein eL33A

1

0

High-throughput

0.249

Low

441901

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

503037

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

689030

RL16A
Large ribosomal subunit protein uL13A

1

0

High-throughput

0.249

Low

801742

SRP72
Signal recognition particle subunit SRP72

1

0

High-throughput

0.249

Low

806486

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

806503

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

806506

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.249

Low

383696

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.232

Low

511795

RS24A
Small ribosomal subunit protein eS24A

1

0

High-throughput

0.232

Low

712566

RL8B
Large ribosomal subunit protein eL8B

1

0

High-throughput

0.232

Low

806463

RL13B
Large ribosomal subunit protein eL13B

1

0

High-throughput

0.232

Low

806470

BNI1
Protein BNI1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025