HitPredict

Interactor 1: SYGP1 (F6SEU4)
Ras/Rap GTPase-activating protein SynGAP (Neuronal RasGAP) (Synaptic Ras GTPase-activating protein 1) (Synaptic Ras-GAP 1)
Gene: Syngap1

Interactor 2: SHAN2 (Q80Z38)
SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin-binding protein 1) (CortBP1)
Gene: Shank2

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	27507650, 28706196, 28671696, 36417873
Identification Methods	affinity chromatography technology, proximity labelling technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0014069 - postsynaptic density GO:0017124 - SH3 domain binding GO:0098978 - glutamatergic synapse
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1340 Mm			1 1476
+	Mm
		99981 SYGP1_MOUSE (1-1340): 0: 1075: 100.00		SHAN3_MOUSE (13-1473): 1.87e-73: 273: 32.70
+	Hs
		1299738 SYGP1_HUMAN (1-1340): 0: 1065: 98.59		SHAN3_HUMAN (13-1473): 8.44e-76: 280: 32.86
+	Mm
		100047 SYGP1_MOUSE (1-1340): 0: 1075: 100.00		SI1L1_MOUSE (206-1013): 8.8e-36: 151: 13.66
+	Hs
		1133698 SYGP1_HUMAN (1-1340): 0: 1065: 98.59		RHG21_HUMAN (242-1011): 7.34e-39: 161: 14.34
+	Mm
		88363 SYGP1_MOUSE (1-1340): 0: 1075: 100.00		SHAN1_MOUSE (366-1476): 2.17e-24: 114: 14.15
+	Mm
		88380 SYGP1_MOUSE (1-1340): 0: 1075: 100.00		D3YZU5_MOUSE (366-1476): 2.08e-24: 114: 14.15
+	Hs
		1299744 SYGP1_HUMAN (1-1340): 0: 1065: 98.59		TARA_HUMAN (16-1340): 5.56e-18: 92.8: 8.50
+	Mm
		100055 SYGP1_MOUSE (1-1340): 0: 1075: 100.00		SYNJ1_MOUSE (980-1381): 4.07e-09: 63.9: 12.44
+	Hs
		1296951 NGAP_HUMAN (84-1338): 0: 800: 43.48		SNX27_HUMAN (247-503): 3.56e-37: 150: 21.01
+	Hs
		196524 NGAP_HUMAN (84-1338): 0: 800: 43.48		SI1L1_HUMAN (206-1018): 1.98e-35: 150: 13.25
+	Hs
		230926 NGAP_HUMAN (84-1338): 0: 800: 43.48		MAST3_HUMAN (246-605): 2.17e-28: 126: 15.66
+	Mm
		980215 NF1_MOUSE (408-712): 3.83e-82: 300: 23.51		SHAN3_MOUSE (13-1473): 1.87e-73: 273: 32.70
+	Hs
		809327 IQGA1_HUMAN (219-723): 6.44e-107: 374: 13.97		RHG21_HUMAN (242-1011): 7.34e-39: 161: 14.34
+	Hs
		230217 IQGA1_HUMAN (219-723): 6.44e-107: 374: 13.97		SI1L3_HUMAN (206-1008): 7.96e-37: 154: 11.74
+	Hs
		196413 IQGA1_HUMAN (219-723): 6.44e-107: 374: 13.97		SI1L1_HUMAN (206-1018): 1.98e-35: 150: 13.25
+	Hs
		809434 IQGA1_HUMAN (219-723): 6.44e-107: 374: 13.97		TARA_HUMAN (16-1340): 5.56e-18: 92.8: 8.50
+	Hs
		196400 NF1_HUMAN (408-712): 2.96e-82: 301: 23.21		SI1L1_HUMAN (206-1018): 1.98e-35: 150: 13.25
+	Hs
		230843 NF1_HUMAN (408-712): 2.96e-82: 301: 23.21		MAST3_HUMAN (246-605): 2.17e-28: 126: 15.66
+	Hs
		598468 NF1_HUMAN (408-712): 2.96e-82: 301: 23.21		PTN13_HUMAN (33-344): 1.29e-09: 65.5: 14.38