Protein: ULK2
Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2)

Gene: ULK2
Organism: Homo sapiens
Interactions: 64
UniProt ID: Q8IYT8

Gene Ontology (top 5):
GO:0000045 - autophagosome assembly
GO:0000407 - phagophore assembly site
GO:0000423 - mitophagy
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1315542

ULK2
Serine/threonine-protein kinase ULK2

2

17

Small-scale

0.712

High

1107910

SQSTM
Sequestosome-1

1

10

Small-scale

0.681

High

1315545

RBCC1
RB1-inducible coiled-coil protein 1

3

18

Small-scale

0.662

High

1315549

ATGA1
Autophagy-related protein 101

3

4

High-throughput

0.662

High

271543

ATG13
Autophagy-related protein 13

3

5

Small-scale

0.657

High

600588

ZNF32
Zinc finger protein 32

1

1

High-throughput

0.625

High

242242

PRKN
E3 ubiquitin-protein ligase parkin

1

12

High-throughput

0.618

High

1140539

KIF14
Kinesin-like protein KIF14

1

8

High-throughput

0.618

High

225637

AAKB2
5'-AMP-activated protein kinase subunit beta-2

1

20

High-throughput

0.575

High

272314

OBSL1
Obscurin-like protein 1

1

2

High-throughput

0.575

High

650851

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

5

High-throughput

0.575

High

691789

MK03
Mitogen-activated protein kinase 3

1

20

High-throughput

0.575

High

718145

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

11

High-throughput

0.575

High

877167

KC1D
Casein kinase I isoform delta

1

15

High-throughput

0.575

High

920103

PLK1
Serine/threonine-protein kinase PLK1

1

17

High-throughput

0.575

High

930749

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

19

High-throughput

0.575

High

1095409

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

19

High-throughput

0.575

High

1158416

CDC37
Hsp90 co-chaperone Cdc37

1

10

High-throughput

0.575

High

1315559

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

20

High-throughput

0.575

High

328067

GBRAP
Gamma-aminobutyric acid receptor-associated protein

2

14

Small-scale

0.563

High

952238

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

2

14

Small-scale

0.563

High

1315546

TNPO1
Transportin-1

1

1

Small-scale

0.561

High

1139758

SETB1
Histone-lysine N-methyltransferase SETDB1

1

3

High-throughput

0.541

High

1150520

DIXC1
Dixin

1

19

High-throughput

0.541

High

1315544

LNX1
E3 ubiquitin-protein ligase LNX

1

7

High-throughput

0.541

High

881073

NASP
Nuclear autoantigenic sperm protein

1

0

High-throughput

0.518

High

1122750

DPOA2
DNA polymerase alpha subunit B

1

0

High-throughput

0.518

High

1252889

BAKOR
Beclin 1-associated autophagy-related key regulator

1

2

Small-scale

0.501

High

1315548

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

6

Small-scale

0.501

High

338898

CBX6
Chromobox protein homolog 6

1

2

High-throughput

0.489

High

138209

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

5

High-throughput

0.479

High

175111

SC16A
Protein transport protein Sec16A

1

3

Small-scale

0.479

High

533949

IRF1
Interferon regulatory factor 1

1

1

High-throughput

0.479

High

1315543

RPTOR
Regulatory-associated protein of mTOR

1

9

Small-scale

0.479

High

1315551

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

14

High-throughput

0.479

High

1315552

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

14

High-throughput

0.479

High

665460

EF1B
Elongation factor 1-beta

1

2

High-throughput

0.457

High

300189

GLRX3
Glutaredoxin-3

1

4

High-throughput

0.445

High

593158

CREB1
Cyclic AMP-responsive element-binding protein 1

1

4

High-throughput

0.445

High

637623

FLNA
Filamin-A

1

10

High-throughput

0.445

High

839314

MTOR
Serine/threonine-protein kinase mTOR

1

13

Small-scale

0.445

High

913537

KIF11
Kinesin-like protein KIF11

1

3

High-throughput

0.445

High

916685

PPP5
Serine/threonine-protein phosphatase 5

1

20

High-throughput

0.445

High

926203

ICLN
Methylosome subunit pICln

1

1

High-throughput

0.445

High

930333

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

14

High-throughput

0.445

High

971762

1433E
14-3-3 protein epsilon

1

20

High-throughput

0.445

High

1049539

1433F
14-3-3 protein eta

1

20

High-throughput

0.445

High

1160682

DREB
Drebrin

1

3

High-throughput

0.445

High

1226704

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

1

10

High-throughput

0.445

High

1315547

IPO9
Importin-9

1

2

High-throughput

0.445

High

1315553

WDR26
WD repeat-containing protein 26

1

7

High-throughput

0.445

High

1315554

WDR6
tRNA

1

12

High-throughput

0.445

High

1315556

AAKG2
5'-AMP-activated protein kinase subunit gamma-2

1

13

High-throughput

0.445

High

1315558

HBS1L
HBS1-like protein

1

4

High-throughput

0.445

High

1315560

WIPI2
WD repeat domain phosphoinositide-interacting protein 2

1

7

High-throughput

0.445

High

1199915

P5CR3
Pyrroline-5-carboxylate reductase 3

1

0

High-throughput

0.426

High

1315555

ADPPT
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

1

0

High-throughput

0.426

High

657631

GCSP
Glycine dehydrogenase

1

1

High-throughput

0.407

High

1058516

CKAP4
Cytoskeleton-associated protein 4

1

13

High-throughput

0.407

High

1111101

SNW1
SNW domain-containing protein 1

1

1

High-throughput

0.407

High

1315550

SSBP3
Single-stranded DNA-binding protein 3

1

2

High-throughput

0.407

High

1315557

LC7L2
Putative RNA-binding protein Luc7-like 2

1

0

High-throughput

0.282

High

316910

MTA2
Metastasis-associated protein MTA2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025