HitPredict

Interactor 1: DLG4 (P78352)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Interactor 2: KCND2 (Q9NZV8)
A-type voltage-gated potassium channel KCND2 (Potassium voltage-gated channel subfamily D member 2) (Voltage-gated potassium channel subunit Kv4.2)
Gene: KCND2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	12435606
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007268 - chemical synaptic transmission GO:0043197 - dendritic spine GO:0045211 - postsynaptic membrane GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 630
+	Mm
		990946 DLG4_MOUSE (1-724): 0: 660: 99.59		KCNA2_MOUSE (5-500): 8.28e-128: 387: 32.06
+	Hs
		595035 DLG4_HUMAN (1-724): 0: 660: 100.00		KCNA2_HUMAN (5-500): 5.76e-127: 385: 32.06
+	Hs
		1006055 DLG4_HUMAN (1-724): 0: 660: 100.00		KCNA1_HUMAN (5-427): 5.82e-125: 380: 34.16
+	Mm
		595024 DLG4_MOUSE (1-724): 0: 660: 99.59		KCNA1_MOUSE (5-427): 3.48e-124: 378: 33.93
+	Hs
		648766 DLG4_HUMAN (1-724): 0: 660: 100.00		KCNA4_HUMAN (35-478): 4.05e-119: 370: 30.72
+	Rn
		583946 DLG4_RAT (1-724): 0: 661: 99.86		KCNA4_RAT (35-478): 1.08e-117: 366: 30.72
+	Mm
		1222743 DLG4_MOUSE (1-724): 0: 660: 99.59		KCNA4_MOUSE (35-478): 1.07e-117: 366: 30.72
+	Hs
		648813 DLG4_HUMAN (1-724): 0: 660: 100.00		KCNA5_HUMAN (34-493): 2.52e-118: 366: 30.81
+	Mm
		595204 DLG4_MOUSE (1-724): 0: 660: 99.59		KCNA3_MOUSE (24-424): 2.9e-116: 358: 35.75
+	Hs
		642796 DLG4_HUMAN (1-724): 0: 660: 100.00		KCNA3_HUMAN (28-424): 2.03e-115: 358: 36.07
+	Mm
		1223402 DLG4_MOUSE (1-724): 0: 660: 99.59		KCNA6_MOUSE (1-482): 8.17e-109: 339: 27.97
+	Hs
		648789 DLG3_HUMAN (28-724): 0: 593: 64.92		KCNA4_HUMAN (35-478): 4.05e-119: 370: 30.72
+	Rn
		583947 DLG3_RAT (9-724): 0: 583: 62.75		KCNA4_RAT (35-478): 1.08e-117: 366: 30.72
+	Rn
		618300 DLG1_RAT (6-724): 0: 562: 67.95		KCNA5_RAT (6-493): 7.3e-124: 380: 30.53
+	Hs
		648769 DLG1_HUMAN (32-724): 0: 572: 73.33		KCNA4_HUMAN (35-478): 4.05e-119: 370: 30.72
+	Hs
		648817 DLG1_HUMAN (32-724): 0: 572: 73.33		KCNA5_HUMAN (34-493): 2.52e-118: 366: 30.81
+	Hs
		873892 DLG1_HUMAN (32-724): 0: 572: 73.33		KCNC1_HUMAN (37-469): 2.38e-118: 363: 31.25
+	Rn
		669443 DLG1_RAT (6-724): 0: 562: 67.95		KCNC1_RAT (37-530): 7.2e-121: 372: 29.08
+	Hs
		642835 DLG1_HUMAN (32-724): 0: 572: 73.33		KCNA3_HUMAN (28-424): 2.03e-115: 358: 36.07
+	Dm
		470412 DLG1_DROME (11-724): 8.57e-166: 504: 47.91		KCNAS_DROME (37-425): 3.46e-113: 355: 35.87