HitPredict

Interactor 1: SMAD3 (P84022)
Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3)
Gene: SMAD3

Interactor 2: FHL3 (Q13643)
Four and a half LIM domains protein 3 (FHL-3) (Skeletal muscle LIM-protein 2) (SLIM-2)
Gene: FHL3

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.60	0.578

Property	Details
Experiments	19139564
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0008270 - zinc ion binding
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 425 Hs			1 280
+	Hs
		212719 SMAD3_HUMAN (1-425): 0: 636: 100.00		TGFI1_HUMAN (3-218): 3.55e-67: 217: 27.32
+	Mm
		1223898 SMAD3_MOUSE (1-425): 0: 636: 100.00		TGFI1_MOUSE (3-218): 7.83e-67: 216: 26.85
+	Hs
		1116479 SMAD2_HUMAN (1-425): 0: 589: 83.73		FHL3_HUMAN (1-280): 8.02e-78: 239: 100.00
+	Hs
		1014580 SMAD3_HUMAN (1-425): 0: 636: 100.00		PDLI5_HUMAN (3-155): 2.4e-47: 168: 28.76
+	Hs
		1014503 SMAD3_HUMAN (1-425): 0: 636: 100.00		FHL1_HUMAN (66-279): 2.76e-43: 151: 29.17
+	Hs
		1116412 SMAD2_HUMAN (1-425): 0: 589: 83.73		FHL1_HUMAN (66-279): 2.76e-43: 151: 29.17
+	Hs
		1014511 SMAD3_HUMAN (1-425): 0: 636: 100.00		FHL2_HUMAN (4-156): 7.56e-25: 101: 26.45
+	Hs
		1122975 SMAD2_HUMAN (1-425): 0: 589: 83.73		FHL2_HUMAN (4-156): 7.56e-25: 101: 26.45
+	Hs
		1106527 SMAD4_HUMAN (23-414): 1.55e-117: 355: 33.21		FHL3_HUMAN (1-280): 8.02e-78: 239: 100.00
+	Hs
		212724 SMAD4_HUMAN (23-414): 1.55e-117: 355: 33.21		TGFI1_HUMAN (3-218): 3.55e-67: 217: 27.32
+	Hs
		177631 SMAD7_HUMAN (28-403): 2.72e-101: 309: 27.06		TGFI1_HUMAN (3-218): 3.55e-67: 217: 27.32
+	Hs
		1106526 SMAD4_HUMAN (23-414): 1.55e-117: 355: 33.21		FHL1_HUMAN (66-279): 2.76e-43: 151: 29.17
+	Hs
		1106533 SMAD4_HUMAN (23-414): 1.55e-117: 355: 33.21		FHL2_HUMAN (4-156): 7.56e-25: 101: 26.45