HitPredict

Interactor 1: FBLN3 (Q12805)
EGF-containing fibulin-like extracellular matrix protein 1 (Extracellular protein S1-5) (Fibrillin-like protein) (Fibulin-3) (FIBL-3)
Gene: EFEMP1

Interactor 2: SHAN3 (Q9BYB0)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2)
Gene: SHANK3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.50	0.494

Property	Details
Experiments	21653829
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 493 Hs			1 1731
+	Hs
		254237 MEGF6_HUMAN (173-347): 3.34e-19: 93.2: 35.91		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		1231801 LTBP4_HUMAN (16-293): 9.63e-18: 89: 19.00		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		980523 NOTC2_HUMAN (5-386): 1.07e-16: 85.7: 10.63		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		1316288 LTBP3_HUMAN (25-293): 4.82e-15: 80.1: 22.76		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		1316311 NOTC3_HUMAN (256-466): 1.98e-13: 75.3: 11.93		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		328048 FBLN4_HUMAN (2-224): 1.75e-12: 71: 18.22		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Hs
		804330 NOTC1_HUMAN (3-312): 5.97e-10: 64.1: 10.61		SHAN3_HUMAN (1-1731): 0: 596: 100.00
+	Dm
		246781 TENM_DROME (136-466): 7.59e-37: 147: 12.95		Q0KIE7_DROME (30-505): 2.28e-87: 318: 16.35
+	Hs
		166914 NOTC2_HUMAN (5-386): 1.07e-16: 85.7: 10.63		ANR28_HUMAN (27-335): 3.42e-77: 281: 16.48
+	Hs
		167042 NOTC3_HUMAN (256-466): 1.98e-13: 75.3: 11.93		ANR28_HUMAN (27-335): 3.42e-77: 281: 16.48
+	Hs
		957287 FBLN2_HUMAN (29-449): 5.23e-13: 73.7: 19.00		TNKS2_HUMAN (220-558): 1.49e-36: 153: 12.29
+	Dm
		114000 CUBN_DROME (171-453): 2.62e-35: 142: 14.33		M9PB30_DROME (349-1110): 2.53e-09: 65.1: 11.73
+	Dm
		65546 NOTCH_DROME (202-436): 4.55e-16: 83.8: 14.46		A8JNM5_DROME (649-1691): 7.65e-24: 112: 11.17
+	Hs
		980449 NOTC2_HUMAN (5-386): 1.07e-16: 85.7: 10.63		ANR44_HUMAN (2-151): 2.27e-20: 100: 14.01
+	Hs
		1237561 NOTC3_HUMAN (256-466): 1.98e-13: 75.3: 11.93		ANR44_HUMAN (2-151): 2.27e-20: 100: 14.01
+	Hs
		944122 JAG1_HUMAN (156-479): 1.92e-18: 91.1: 12.50		MIB1_HUMAN (129-324): 9.56e-15: 82: 32.50
+	Hs
		804293 NOTC1_HUMAN (3-312): 5.97e-10: 64.1: 10.61		ANR44_HUMAN (2-151): 2.27e-20: 100: 14.01
+	Dm
		422915 NOTCH_DROME (202-436): 4.55e-16: 83.8: 14.46		MIB_DROME (134-324): 1.09e-12: 75.5: 32.31
+	Mm
		1193398 JAG1_MOUSE (5-236): 3.76e-09: 61.4: 13.31		MIB1_MOUSE (129-324): 1.56e-14: 81.6: 32.50
+	Dm
		113976 M9PB30_DROME (29-380): 1.31e-12: 72.8: 24.82		M9PB30_DROME (349-1110): 2.53e-09: 65.1: 11.73