HitPredict

Interactor 1: MAX (P91664)
Protein max (dMax) (Myc-associated factor X)
Gene: MAX

Interactor 2: MYC (Q9W4S7)
Myc proto-oncogene protein (dMyc) (Protein diminutive)
Gene: MYC

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.918

Property	Details
Experiments	27626673, 19165923, 14605208, 17898168, unassigned4
Identification Methods	affinity chromatography technology, two hybrid, pull down, experimental interaction detection
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0003677 - DNA binding GO:0003700 - DNA-binding transcription factor activity GO:0005634 - nucleus GO:0006355 - regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 161 Dm			1 717
+	Hs
		372942 MNT_HUMAN (24-154): 6.92e-27: 107: 22.90		MYC_HUMAN (455-714): 1.71e-58: 206: 28.14
+	At
		236052 MYC4_ARATH (2-159): 1.08e-30: 117: 21.34		MYC2_ARATH (446-710): 2.54e-40: 158: 18.68
+	At
		1184594 MYC2_ARATH (1-155): 8.61e-27: 106: 21.21		MYC2_ARATH (446-710): 2.54e-40: 158: 18.68
+	Hs
		648332 SRBP1_HUMAN (8-152): 6.02e-31: 119: 18.00		USF1_HUMAN (438-713): 8.47e-34: 133: 15.41
+	Hs
		1405470 MNT_HUMAN (24-154): 6.92e-27: 107: 22.90		MNT_HUMAN (497-711): 1.18e-35: 144: 20.54
+	Hs
		648363 USF2_HUMAN (20-131): 1.7e-29: 111: 25.21		USF1_HUMAN (438-713): 8.47e-34: 133: 15.41
+	Hs
		1405471 MNT_HUMAN (24-154): 6.92e-27: 107: 22.90		MAD3_HUMAN (583-706): 3.16e-32: 125: 23.81
+	Hs
		1155120 USF2_HUMAN (20-131): 1.7e-29: 111: 25.21		USF2_HUMAN (488-711): 5.65e-28: 117: 18.57
+	At
		236048 MYC4_ARATH (2-159): 1.08e-30: 117: 21.34		MYC4_ARATH (491-716): 3.98e-23: 106: 16.59
+	At
		236063 MYC4_ARATH (2-159): 1.08e-30: 117: 21.34		MYC3_ARATH (503-701): 2.2e-22: 103: 16.58
+	Mm
		1490127 SRBP1_MOUSE (8-156): 4.12e-30: 116: 18.18		SRBP1_MOUSE (449-705): 1.86e-21: 102: 13.95
+	Hs
		787844 SRBP1_HUMAN (8-152): 6.02e-31: 119: 18.00		SRBP1_HUMAN (421-705): 3.9e-20: 98: 13.68
+	Mm
		148315 MNT_MOUSE (24-158): 3.09e-28: 111: 22.22		MAX_MOUSE (602-714): 2.39e-23: 98.8: 25.00
+	At
		1184615 MYC2_ARATH (1-155): 8.61e-27: 106: 21.21		MYC3_ARATH (503-701): 2.2e-22: 103: 16.58
+	Hs
		959643 MNT_HUMAN (24-154): 6.92e-27: 107: 22.90		MAX_HUMAN (602-714): 6.67e-23: 97.6: 25.00
+	Rn
		481014 MYC_RAT (23-123): 1.71e-26: 105: 28.43		MAX_RAT (602-714): 2.15e-23: 99.2: 25.00
+	Hs
		787865 SRBP2_HUMAN (34-153): 3.63e-26: 105: 19.20		SRBP1_HUMAN (421-705): 3.9e-20: 98: 13.68
+	Hs
		1050748 MNT_HUMAN (24-154): 6.92e-27: 107: 22.90		MAD1_HUMAN (583-708): 2.36e-16: 80.7: 19.84