Protein: MAD1
Max dimerization protein 1 (Max dimerizer 1) (Protein MAD)

Gene: MAD1, MXD1
Organism: Homo sapiens
Interactions: 41
UniProt ID: Q05195

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

959568

MAX
Protein max

16

18

Small-scale

0.984

High

1050756

MLX
Max-like protein X

2

19

Small-scale

0.768

High

1050746

SIN3A
Paired amphipathic helix protein Sin3a

8

17

Small-scale

0.752

High

711762

ARI4A
AT-rich interactive domain-containing protein 4A

3

20

High-throughput

0.667

High

1050739

ARI4B
AT-rich interactive domain-containing protein 4B

3

20

High-throughput

0.667

High

1050740

BRM1L
Breast cancer metastasis-suppressor 1-like protein

3

9

High-throughput

0.667

High

1050751

SP130
Histone deacetylase complex subunit SAP130

3

11

High-throughput

0.667

High

1050752

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

3

9

High-throughput

0.667

High

1050753

SP30L
Histone deacetylase complex subunit SAP30L

3

5

High-throughput

0.667

High

728186

AKT1
RAC-alpha serine/threonine-protein kinase

2

6

Small-scale

0.646

High

371831

MYC
Myc proto-oncogene protein

1

18

Small-scale

0.618

High

1050736

MAD4
Max dimerization protein 4

1

17

Small-scale

0.618

High

1050741

MGAP
MAX gene-associated protein

1

5

Small-scale

0.618

High

1050748

MNT
Max-binding protein MNT

1

17

Small-scale

0.618

High

1050749

MAD3
Max dimerization protein 3

1

17

Small-scale

0.618

High

1050754

BRMS1
Breast cancer metastasis-suppressor 1

2

9

High-throughput

0.611

High

1050744

HDAC2
Histone deacetylase 2

2

12

Small-scale

0.595

High

1050733

BIRC2
Baculoviral IAP repeat-containing protein 2

1

6

Small-scale

0.586

High

658593

KS6B1
Ribosomal protein S6 kinase beta-1

1

6

Small-scale

0.536

High

1050737

KS6A1
Ribosomal protein S6 kinase alpha-1

1

7

Small-scale

0.536

High

1050757

SMC3
Structural maintenance of chromosomes protein 3

1

10

Small-scale

0.527

High

1050755

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.513

High

282241

SAP30
Histone deacetylase complex subunit SAP30

1

5

Small-scale

0.501

High

421968

A4
Amyloid-beta precursor protein

1

7

High-throughput

0.501

High

1050734

HDAC1
Histone deacetylase 1

1

12

Small-scale

0.501

High

282704

E2F6
Transcription factor E2F6

1

7

Small-scale

0.479

High

543495

VDR
Vitamin D3 receptor

1

5

Small-scale

0.479

High

606672

CEBPB
CCAAT/enhancer-binding protein beta

1

20

Small-scale

0.479

High

711814

KDM5A
Lysine-specific demethylase 5A

1

4

Small-scale

0.479

High

886785

CEBPA
CCAAT/enhancer-binding protein alpha

1

20

Small-scale

0.479

High

958935

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

2

High-throughput

0.479

High

1050730

RING1
E3 ubiquitin-protein ligase RING1

1

18

Small-scale

0.479

High

1050731

CBX3
Chromobox protein homolog 3

1

13

Small-scale

0.479

High

1050735

TFDP1
Transcription factor Dp-1

1

4

Small-scale

0.479

High

1050738

CEBPE
CCAAT/enhancer-binding protein epsilon

1

19

Small-scale

0.479

High

1050742

YAF2
YY1-associated factor 2

1

4

Small-scale

0.479

High

1050743

RYBP
RING1 and YY1-binding protein

1

4

Small-scale

0.479

High

1050745

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

8

Small-scale

0.479

High

1050747

RING2
E3 ubiquitin-protein ligase RING2

1

20

Small-scale

0.479

High

1050750

PCGF6
Polycomb group RING finger protein 6

1

17

Small-scale

0.479

High

1050732

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

Small-scale

0.445

High


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Last updated: 11Aug2025