HitPredict

Interactor 1: ANK3 (Q12955)
Ankyrin-3 (ANK-3) (Ankyrin-G)
Gene: ANK3

Interactor 2: SPTN1 (Q13813)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)
Gene: SPTAN1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~EF-hand_7, Ank_2~SH3_1, Spectrin~UPA_2, Spectrin~ZU5
Common GO terms	GO:0005200 - structural constituent of cytoskeleton GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0045296 - cadherin binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 4377 Hs			1 2472
+	Hs
		164611 ANK3_HUMAN (1-4377): 0: 1944: 100.00		SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41
+	Hs
		963306 ANK3_HUMAN (1-4377): 0: 1944: 100.00		SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52
+	Hs
		1021404 ANK3_HUMAN (1-4377): 0: 1944: 100.00		PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18
+	Hs
		1021458 ANK3_HUMAN (1-4377): 0: 1944: 100.00		SPTN4_HUMAN (961-2371): 1.09e-21: 105: 13.80
+	Hs
		360612 ANK1_HUMAN (1-683): 0: 722: 34.22		SPTA1_HUMAN (1-2472): 2.98e-159: 552: 54.81
+	Hs
		556695 ANK1_HUMAN (1-683): 0: 722: 34.22		SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52
+	Mm
		82740 ANK3_MOUSE (3991-4376): 7.67e-34: 147: 40.98		B9EKJ1_MOUSE (1-2472): 0: 706: 98.18
+	Hs
		965102 ANK2_HUMAN (3012-4350): 1.52e-22: 110: 9.15		SPTN1_HUMAN (1-2472): 0: 714: 100.00
+	Mm
		561172 ANK2_MOUSE (3425-4374): 7.13e-17: 91.3: 7.94		SPTN1_MOUSE (1-2472): 0: 712: 98.42
+	Hs
		506803 ANK1_HUMAN (1-683): 0: 722: 34.22		SPTB1_HUMAN (1743-2409): 3.32e-13: 78.1: 19.70
+	Hs
		211682 ANFY1_HUMAN (270-925): 8.88e-121: 417: 18.16		ACTN4_HUMAN (1843-2219): 1.15e-09: 66.2: 20.15
+	Rn
		251022 ANK3_RAT (3205-4376): 1.6e-63: 245: 27.49		PLEC_RAT (1-1257): 6.84e-37: 156: 10.91
+	Mm
		57416 A2AM57_MOUSE (4-259): 8.55e-52: 204: 25.76		Q6S385_MOUSE (1-1250): 9.23e-38: 159: 10.80
+	Mm
		57440 A2AM57_MOUSE (4-259): 8.55e-52: 204: 25.76		PLEC_MOUSE (1-1250): 7.03e-38: 159: 10.80
+	Hs
		164604 ANK2_HUMAN (3012-4350): 1.52e-22: 110: 9.15		SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41
+	Mm
		103598 ANK3_MOUSE (3991-4376): 7.67e-34: 147: 40.98		Q3UGX2_MOUSE (2-1625): 2.78e-45: 183: 19.60
+	Hs
		963292 ANK2_HUMAN (3012-4350): 1.52e-22: 110: 9.15		SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52
+	Mm
		103603 ANK3_MOUSE (3991-4376): 7.67e-34: 147: 40.98		SPTB2_MOUSE (1408-2420): 1.22e-29: 132: 18.86
+	Hs
		965174 ANK2_HUMAN (3012-4350): 1.52e-22: 110: 9.15		MACF1_HUMAN (9-1261): 9.1e-18: 93.6: 12.48