HitPredict

Interactor 1: M4K4 (P97820)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: Map4k4

Interactor 2: PTK7 (Q8BKG3)
Inactive tyrosine-protein kinase 7 (Protein chuzhoi) (Protein-tyrosine kinase 7) (Pseudo tyrosine kinase receptor 7) (Tyrosine-protein kinase-like 7)
Gene: PTK7

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	36417873
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	I-set~Pkinase, PK_Tyr_Ser-Thr~Pkinase
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1233 Mm			1 1062
+	Mm
		1296899 MINK1_MOUSE (1-1233): 0: 1056: 59.12		PTK7_MOUSE (1-1062): 0: 936: 100.00
+	Hs
		348036 M4K4_HUMAN (1-1233): 0: 1083: 89.00		IGF1R_HUMAN (779-1053): 5.66e-52: 201: 36.33
+	Hs
		348227 M4K4_HUMAN (1-1233): 0: 1083: 89.00		ALK_HUMAN (687-1049): 7.36e-52: 201: 32.98
+	Hs
		348056 M4K4_HUMAN (1-1233): 0: 1083: 89.00		FGFR4_HUMAN (101-407): 2.34e-42: 169: 18.72
+	Hs
		1461048 TNIK_HUMAN (1-1233): 0: 1049: 60.44		ALK_HUMAN (687-1049): 7.36e-52: 201: 32.98
+	Hs
		348044 M4K4_HUMAN (1-1233): 0: 1083: 89.00		FGFR1_HUMAN (21-223): 1.14e-34: 145: 17.11
+	Hs
		648726 TNIK_HUMAN (1-1233): 0: 1049: 60.44		FGFR4_HUMAN (101-407): 2.34e-42: 169: 18.72
+	Hs
		541588 MINK1_HUMAN (1-1233): 0: 1052: 58.61		FGFR1_HUMAN (21-223): 1.14e-34: 145: 17.11
+	Hs
		541750 TNIK_HUMAN (1-1233): 0: 1049: 60.44		FGFR1_HUMAN (21-223): 1.14e-34: 145: 17.11
+	Mm
		581980 TNIK_MOUSE (1-1233): 0: 1071: 62.05		NTRK2_MOUSE (128-302): 2.31e-19: 95.9: 21.55
+	Hs
		249078 M4K4_HUMAN (1-1233): 0: 1083: 89.00		DSCAM_HUMAN (10-125): 1.25e-12: 74.7: 16.67
+	Hs
		348029 M4K4_HUMAN (1-1233): 0: 1083: 89.00		NTRK1_HUMAN (402-602): 9.05e-11: 68.2: 20.69
+	Hs
		348130 M4K4_HUMAN (1-1233): 0: 1083: 89.00		NTRK3_HUMAN (584-691): 2.28e-10: 67: 22.73
+	Hs
		1159515 MINK1_HUMAN (1-1233): 0: 1052: 58.61		NTRK2_HUMAN (128-305): 3.58e-19: 95.5: 20.65
+	Hs
		1156996 MINK1_HUMAN (1-1233): 0: 1052: 58.61		NTRK3_HUMAN (584-691): 2.28e-10: 67: 22.73
+	Hs
		1157105 TNIK_HUMAN (1-1233): 0: 1049: 60.44		NTRK3_HUMAN (584-691): 2.28e-10: 67: 22.73
+	Hs
		1270553 MARK2_HUMAN (8-672): 1.37e-126: 410: 15.25		ALK_HUMAN (687-1049): 7.36e-52: 201: 32.98
+	Hs
		541351 MARK3_HUMAN (14-672): 4.32e-124: 402: 15.36		FGFR1_HUMAN (21-223): 1.14e-34: 145: 17.11
+	Hs
		412142 MARK2_HUMAN (8-672): 1.37e-126: 410: 15.25		NTRK1_HUMAN (402-602): 9.05e-11: 68.2: 20.69
+	Hs
		411397 MARK3_HUMAN (14-672): 4.32e-124: 402: 15.36		NTRK1_HUMAN (402-602): 9.05e-11: 68.2: 20.69