HitPredict

Interactor 1: HSPB3 (Q12988)
Heat shock protein beta-3 (HspB3) (Heat shock 17 kDa protein) (HSP 17) (Heat shock protein family B member 3) (Protein 3)
Gene: HSPB3

Interactor 2: HSPB2 (Q16082)
Heat shock protein beta-2 (HspB2) (DMPK-binding protein) (MKBP) (Heat shock protein family B member 2)
Gene: HSPB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	10625651
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Crystallin~HSP20, HSP20~HSP20
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006986 - response to unfolded protein
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 150 Hs			1 182
+	Hs
		358696 CRYAA_HUMAN (13-145): 2.73e-48: 155: 30.83		CRYAA_HUMAN (5-174): 1.85e-56: 177: 34.30
+	Hs
		358767 CRYAA_HUMAN (13-145): 2.73e-48: 155: 30.83		HSPB2_HUMAN (1-164): 1.46e-56: 177: 100.00
+	Hs
		359021 CRYAB_HUMAN (13-147): 1.32e-47: 153: 27.41		HSPB2_HUMAN (1-164): 1.46e-56: 177: 100.00
+	Hs
		358697 CRYAA_HUMAN (13-145): 2.73e-48: 155: 30.83		CRYAB_HUMAN (6-174): 2.32e-55: 174: 35.67
+	Hs
		358699 CRYAA_HUMAN (13-145): 2.73e-48: 155: 30.83		HSPB1_HUMAN (1-179): 7.82e-55: 174: 32.85
+	Hs
		358941 CRYAA_HUMAN (13-145): 2.73e-48: 155: 30.83		V9HW27_HUMAN (6-174): 2.32e-55: 174: 35.67
+	Hs
		1378434 V9HW27_HUMAN (13-147): 1.32e-47: 153: 27.41		V9HW27_HUMAN (6-174): 2.32e-55: 174: 35.67
+	Hs
		358943 CRYAB_HUMAN (13-147): 1.32e-47: 153: 27.41		CRYAB_HUMAN (6-174): 2.32e-55: 174: 35.67
+	Hs
		358950 CRYAB_HUMAN (13-147): 1.32e-47: 153: 27.41		HSPB1_HUMAN (1-179): 7.82e-55: 174: 32.85
+	Bt
		358695 CRYAB_BOVIN (13-149): 2.78e-48: 155: 27.74		CRYAA_BOVIN (6-174): 8.82e-54: 170: 33.33
+	Rn
		621311 CRYAB_RAT (13-149): 1.86e-48: 155: 27.01		HSPB1_RAT (1-179): 7.85e-52: 166: 29.81
+	Dm
		359118 HSP23_DROME (1-150): 6.4e-48: 154: 29.14		HSP26_DROME (36-178): 5.51e-41: 139: 23.68
+	Hs
		147843 CRYAB_HUMAN (13-147): 1.32e-47: 153: 27.41		HSPB6_HUMAN (6-144): 5.8e-42: 139: 40.28
+	Hs
		1022271 HSPB3_HUMAN (1-150): 7.66e-48: 153: 100.00		HSPB8_HUMAN (1-170): 1.27e-38: 132: 25.00
+	Hs
		359087 CRYAB_HUMAN (13-147): 1.32e-47: 153: 27.41		HSPB8_HUMAN (1-170): 1.27e-38: 132: 25.00
+	Dm
		359119 HSP23_DROME (1-150): 6.4e-48: 154: 29.14		HSP27_DROME (4-179): 3.11e-34: 121: 25.63
+	Dm
		359124 HSP23_DROME (1-150): 6.4e-48: 154: 29.14		HSP6C_DROME (69-182): 3.56e-34: 121: 32.52
+	Dm
		359096 HSP23_DROME (1-150): 6.4e-48: 154: 29.14		HSP22_DROME (33-180): 4.25e-30: 110: 21.85