HitPredict

Interactor 1: STX3 (Q13277)
Syntaxin-3
Gene: STX3

Interactor 2: STXB2 (Q15833)
Syntaxin-binding protein 2 (Protein unc-18 homolog 2) (Unc18-2) (Protein unc-18 homolog B) (Unc-18B)
Gene: STXBP2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.947

Property	Details
Experiments	26186194, 26553929, 28514442, 29360461, 33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SNARE~Sec1, Sec1~Syntaxin
Common GO terms	GO:0005886 - plasma membrane GO:0006886 - intracellular protein transport GO:0042581 - specific granule GO:0042582 - azurophil granule GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 289 Hs			1 593
+	Hs
		699262 STX2_HUMAN (1-287): 3.91e-77: 238: 63.45		STXB2_HUMAN (1-593): 0: 709: 100.00
+	Mm
		192851 STX1A_MOUSE (1-287): 5.47e-77: 237: 63.45		STXB2_MOUSE (1-593): 0: 706: 94.77
+	Rn
		699178 STX1A_RAT (1-287): 4.85e-77: 238: 63.45		STXB2_RAT (1-593): 0: 689: 93.94
+	Rn
		838510 STX2_RAT (1-265): 2.61e-69: 217: 63.06		STXB2_RAT (1-593): 0: 689: 93.94
+	Mm
		139543 STX1B_MOUSE (1-288): 3.94e-79: 243: 59.79		STXB1_MOUSE (1-591): 0: 632: 63.47
+	Rn
		898824 STX1B_RAT (1-288): 3.94e-79: 243: 59.79		STXB1_RAT (1-591): 0: 632: 63.47
+	Hs
		898829 STX1B_HUMAN (1-288): 3.94e-79: 243: 59.79		STXB1_HUMAN (1-591): 0: 632: 63.47
+	Rn
		699173 STX1A_RAT (1-287): 4.85e-77: 238: 63.45		STXB1_RAT (1-591): 0: 632: 63.47
+	Hs
		699253 STX2_HUMAN (1-287): 3.91e-77: 238: 63.45		STXB1_HUMAN (1-591): 0: 632: 63.47
+	Mm
		139528 STX1A_MOUSE (1-287): 5.47e-77: 237: 63.45		STXB1_MOUSE (1-591): 0: 632: 63.47
+	Bt
		699167 STX1A_BOVIN (1-287): 8.82e-77: 237: 63.10		STXB1_BOVIN (1-591): 0: 632: 63.47
+	Hs
		901790 STX1A_HUMAN (1-286): 4.49e-75: 233: 62.98		STXB1_HUMAN (1-591): 0: 632: 63.47
+	Hs
		901780 STX3_HUMAN (1-289): 6.42e-71: 222: 100.00		STXB1_HUMAN (1-591): 0: 632: 63.47
+	Rn
		838509 STX2_RAT (1-265): 2.61e-69: 217: 63.06		STXB1_RAT (1-591): 0: 632: 63.47
+	Rn
		901846 STX3_RAT (1-288): 3.86e-69: 217: 98.26		STXB1_RAT (1-591): 0: 632: 63.47
+	Dm
		991124 STX1A_DROME (2-284): 1.93e-73: 228: 55.59		ROP_DROME (4-587): 0: 600: 54.33
+	Hs
		119613 STX2_HUMAN (1-287): 3.91e-77: 238: 63.45		STXB3_HUMAN (1-592): 0: 577: 46.14
+	Ce
		183451 STX1A_CAEEL (2-282): 5.06e-72: 225: 56.18		UNC18_CAEEL (4-588): 0: 588: 52.78
+	Dm
		1096639 STX1A_DROME (2-284): 1.93e-73: 228: 55.59		SLY1_DROME (20-588): 1.3e-136: 413: 17.14
+	Hs
		1030174 STX3_HUMAN (1-289): 6.42e-71: 222: 100.00		SCFD1_HUMAN (7-586): 6.59e-138: 417: 17.97