Protein: SYMPK
Symplekin

Gene: SYMPK
Organism: Homo sapiens
Interactions: 193
UniProt ID: Q92797

Gene Ontology (top 5):
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex
GO:0005856 - cytoskeleton

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1368761

SSU72
RNA polymerase II subunit A C-terminal domain phosphatase SSU72

2

3

Small-scale

0.834

High

1368772

CPSF2
Cleavage and polyadenylation specificity factor subunit 2

7

7

Small-scale

0.746

High

750463

CSTF2
Cleavage stimulation factor subunit 2

5

3

Small-scale

0.721

High

1368775

CPSF3
Cleavage and polyadenylation specificity factor subunit 3

5

8

Small-scale

0.716

High

774533

BASI
Basigin

5

1

High-throughput

0.712

High

340767

CPSF4
Cleavage and polyadenylation specificity factor subunit 4

4

2

High-throughput

0.699

High

1368754

CSTFT
Cleavage stimulation factor subunit 2 tau variant

4

3

High-throughput

0.691

High

1368752

WDR33
pre-mRNA 3' end processing protein WDR33

4

1

Small-scale

0.683

High

1368748

CPEB1
Cytoplasmic polyadenylation element-binding protein 1

4

0

Small-scale

0.667

High

1368746

KLDC3
Kelch domain-containing protein 3

4

0

High-throughput

0.661

High

1083413

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

3

2

High-throughput

0.656

High

291687

XRP2
Protein XRP2

3

0

High-throughput

0.638

High

332688

LYPD3
Ly6/PLAUR domain-containing protein 3

3

0

High-throughput

0.638

High

1092338

CSTF3
Cleavage stimulation factor subunit 3

2

1

High-throughput

0.611

High

1160231

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

2

1

High-throughput

0.611

High

1248052

FIP1
Pre-mRNA 3'-end-processing factor FIP1

2

1

High-throughput

0.611

High

1128934

I13R2
Interleukin-13 receptor subunit alpha-2

2

0

High-throughput

0.602

High

191377

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

2

1

High-throughput

0.601

High

714317

PML
Protein PML

2

1

High-throughput

0.584

High

1368770

WWOX
WW domain-containing oxidoreductase

2

0

High-throughput

0.582

High

542143

TOP1
DNA topoisomerase 1

2

0

Small-scale

0.577

High

388264

GLPA
Glycophorin-A

2

0

High-throughput

0.576

High

129304

MEN1
Menin

2

0

High-throughput

0.559

High

589312

RFA2
Replication protein A 32 kDa subunit

2

0

High-throughput

0.559

High

696105

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

0

High-throughput

0.559

High

731513

STIP1
Stress-induced-phosphoprotein 1

2

0

High-throughput

0.559

High

768798

RFA3
Replication protein A 14 kDa subunit

2

0

High-throughput

0.559

High

1368782

KDM3A
Lysine-specific demethylase 3A

2

0

High-throughput

0.559

High

1347826

RIN3
Ras and Rab interactor 3

2

0

High-throughput

0.551

High

1368747

TRI55
Tripartite motif-containing protein 55

1

2

High-throughput

0.541

High

599845

YBOX3
Y-box-binding protein 3

1

0

Small-scale

0.537

High

1368549

KAT6A
Histone acetyltransferase KAT6A

1

0

Small-scale

0.537

High

182704

GP182
G-protein coupled receptor 182

1

1

High-throughput

0.536

High

445230

S10A6
Protein S100-A6

1

1

High-throughput

0.536

High

478139

SNRPA
U1 small nuclear ribonucleoprotein A

1

1

High-throughput

0.536

High

937647

FOXG1
Forkhead box protein G1

1

4

High-throughput

0.536

High

1329787

SIR6
NAD-dependent protein deacylase sirtuin-6

1

1

High-throughput

0.536

High

1368743

CDC5L
Cell division cycle 5-like protein

1

1

High-throughput

0.536

High

1368751

SEM4C
Semaphorin-4C

1

1

High-throughput

0.536

High

1368757

STPAP
Speckle targeted PIP5K1A-regulated poly(A) polymerase

1

1

Small-scale

0.536

High

1368784

NPTN
Neuroplastin

1

1

High-throughput

0.536

High

280755

PR40A
Pre-mRNA-processing factor 40 homolog A

1

1

High-throughput

0.515

High

158479

RFXK
DNA-binding protein RFXANK

1

0

High-throughput

0.513

High

274690

DNJB6
DnaJ homolog subfamily B member 6

1

0

High-throughput

0.513

High

281769

VP26A
Vacuolar protein sorting-associated protein 26A

1

0

High-throughput

0.513

High

298210

DCTN3
Dynactin subunit 3

1

0

High-throughput

0.513

High

341999

CEP43
Centrosomal protein 43

1

0

High-throughput

0.513

High

389461

FINC
Fibronectin

1

0

High-throughput

0.513

High

452355

PDIA1
Protein disulfide-isomerase

1

0

High-throughput

0.513

High

574399

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

High-throughput

0.513

High

611935

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.513

High

636876

GSTM3
Glutathione S-transferase Mu 3

1

0

High-throughput

0.513

High

691811

MK03
Mitogen-activated protein kinase 3

1

0

High-throughput

0.513

High

775236

FUS
RNA-binding protein FUS

1

0

High-throughput

0.513

High

914316

EFNA4
Ephrin-A4

1

0

High-throughput

0.513

High

956963

CXCR4
C-X-C chemokine receptor type 4

1

0

High-throughput

0.513

High

1041783

PPARD
Peroxisome proliferator-activated receptor delta

1

0

High-throughput

0.513

High

1065337

SSRP1
FACT complex subunit SSRP1

1

0

High-throughput

0.513

High

1111153

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.513

High

1151491

IKBB
NF-kappa-B inhibitor beta

1

0

High-throughput

0.513

High

1242353

PLBL1
Phospholipase B-like 1

1

0

High-throughput

0.513

High

1242685

KLC3
Kinesin light chain 3

1

0

High-throughput

0.513

High

1313670

IFT20
Intraflagellar transport protein 20 homolog

1

0

High-throughput

0.513

High

1334715

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.513

High

1368739

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.513

High

1368740

ELMO3
Engulfment and cell motility protein 3

1

0

High-throughput

0.513

High

1368742

RBM14
RNA-binding protein 14

1

0

High-throughput

0.513

High

1368749

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

1368760

MKNK2
MAP kinase-interacting serine/threonine-protein kinase 2

1

0

High-throughput

0.513

High

1368785

RM42
Large ribosomal subunit protein mL42

1

0

High-throughput

0.513

High

1026489

HSF1
Heat shock factor protein 1

1

0

Small-scale

0.504

High

899761

PAPOA
Poly(A) polymerase alpha

1

2

Small-scale

0.500

High

361324

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.493

High

562284

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

High-throughput

0.493

High

791596

SYUA
Alpha-synuclein

1

0

High-throughput

0.493

High

843827

HD
Huntingtin

1

0

High-throughput

0.493

High

937078

CASP6
Caspase-6

1

0

High-throughput

0.493

High

981619

RAN
GTP-binding nuclear protein Ran

1

0

High-throughput

0.493

High

1023588

CYC
Cytochrome c

1

0

High-throughput

0.493

High

1096138

TADBP
TAR DNA-binding protein 43

1

0

High-throughput

0.493

High

133123

FOXE1
Forkhead box protein E1

1

3

High-throughput

0.489

High

288126

FOXH1
Forkhead box protein H1

1

5

High-throughput

0.489

High

567045

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

1

High-throughput

0.489

High

706246

S10A2
Protein S100-A2

1

1

High-throughput

0.489

High

1091328

FOXL1
Forkhead box protein L1

1

4

High-throughput

0.489

High

1253576

FOXI2
Forkhead box protein I2

1

3

High-throughput

0.489

High

1368745

FOXB1
Forkhead box protein B1

1

5

High-throughput

0.489

High

1368750

FOXQ1
Forkhead box protein Q1

1

5

High-throughput

0.489

High

1368783

WIF1
Wnt inhibitory factor 1

1

1

High-throughput

0.489

High

1368738

TRI63
E3 ubiquitin-protein ligase TRIM63

1

2

High-throughput

0.481

High

964398

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.480

High

993685

UBC9
SUMO-conjugating enzyme UBC9

1

0

Small-scale

0.480

High

1240673

CDC73
Parafibromin

1

0

Small-scale

0.479

High

124820

AIP
AH receptor-interacting protein

1

2

High-throughput

0.479

High

321864

PCF11
Pre-mRNA cleavage complex 2 protein Pcf11

1

1

High-throughput

0.479

High

472942

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

4

High-throughput

0.479

High

519539

MYBB
Myb-related protein B

1

1

High-throughput

0.479

High

520248

ANDR
Androgen receptor

1

1

High-throughput

0.479

High

862342

YAP1
Transcriptional coactivator YAP1

1

1

High-throughput

0.479

High

1038675

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

3

High-throughput

0.479

High

1106022

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

3

High-throughput

0.479

High

1244980

GLD2
Poly(A) RNA polymerase GLD2

1

2

Small-scale

0.479

High

1254896

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

1308565

NUDC3
NudC domain-containing protein 3

1

2

High-throughput

0.479

High

1358074

NUDC2
NudC domain-containing protein 2

1

2

High-throughput

0.479

High

1366936

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1368762

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

1

3

High-throughput

0.479

High

1368763

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

High-throughput

0.479

High

1368778

NUDC
Nuclear migration protein nudC

1

2

High-throughput

0.479

High

1368780

SGT1
Protein SGT1 homolog

1

1

High-throughput

0.479

High

157697

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

218576

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

260247

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

325960

UBR5
E3 ubiquitin-protein ligase UBR5

1

0

High-throughput

0.458

High

342991

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

High-throughput

0.458

High

372740

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

412371

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

537634

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

606965

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

646906

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.458

High

659547

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.458

High

664783

CCND1
G1/S-specific cyclin-D1

1

0

High-throughput

0.458

High

703012

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.458

High

904990

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

934943

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

958168

ARP3
Actin-related protein 3

1

0

High-throughput

0.458

High

980080

H4
Histone H4

1

0

High-throughput

0.458

High

1004917

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

1041574

KMT2A
Histone-lysine N-methyltransferase 2A

1

0

Small-scale

0.458

High

1124123

NPAT
Protein NPAT

1

0

High-throughput

0.458

High

1128077

DHX8
ATP-dependent RNA helicase DHX8

1

0

High-throughput

0.458

High

1207922

SAMD9
Sterile alpha motif domain-containing protein 9

1

0

High-throughput

0.458

High

1220707

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

1229602

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1249072

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1280101

UBE3D
E3 ubiquitin-protein ligase E3D

1

0

High-throughput

0.458

High

1288551

ZN598
E3 ubiquitin-protein ligase ZNF598

1

0

High-throughput

0.458

High

1313309

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

1314340

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.458

High

1339635

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

1349673

CIP2A
Protein CIP2A

1

0

High-throughput

0.458

High

1352667

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1353398

UBP33
Ubiquitin carboxyl-terminal hydrolase 33

1

0

Small-scale

0.458

High

1364488

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1368737

GLMN
Glomulin

1

0

High-throughput

0.458

High

1368744

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

0

High-throughput

0.458

High

1368755

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

0

High-throughput

0.458

High

1368756

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

1368758

SFR19
Splicing factor, arginine/serine-rich 19

1

0

High-throughput

0.458

High

1368759

CYBP
Calcyclin-binding protein

1

0

High-throughput

0.458

High

1368764

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

1368765

KTU
Protein kintoun

1

0

High-throughput

0.458

High

1368768

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1368769

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1368771

NOP53
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.458

High

1368773

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1368774

TASOR
Protein TASOR

1

0

High-throughput

0.458

High

1368776

C8AP2
CASP8-associated protein 2

1

0

High-throughput

0.458

High

1368779

GSTK1
Glutathione S-transferase kappa 1

1

0

High-throughput

0.458

High

166376

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

1

High-throughput

0.445

High

430191

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

1337893

ZNT7
Zinc transporter 7

1

1

High-throughput

0.445

High

1368767

SCN3B
Sodium channel regulatory subunit beta-3

1

1

High-throughput

0.445

High

248922

GSDME
Gasdermin-E

1

0

High-throughput

0.426

High

330260

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.426

High

379557

IGHM
Immunoglobulin heavy constant mu

1

0

High-throughput

0.426

High

437753

HEPS
Serine protease hepsin

1

0

High-throughput

0.426

High

896426

ERF
ETS domain-containing transcription factor ERF

1

0

High-throughput

0.426

High

1146957

PCBP2
Poly(rC)-binding protein 2

1

0

Small-scale

0.426

High

1181411

P3H1
Prolyl 3-hydroxylase 1

1

0

High-throughput

0.426

High

1239263

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.426

High

1292270

S2611
Sodium-independent sulfate anion transporter

1

0

High-throughput

0.426

High

1325783

FXL16
F-box/LRR-repeat protein 16

1

0

High-throughput

0.426

High

1366155

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.426

High

1330723

SIGL1
SIGLEC family-like protein 1

3

0

High-throughput

0.345

High

1368766

OCAD1
OCIA domain-containing protein 1

2

0

High-throughput

0.313

High

209084

CYB5B
Cytochrome b5 type B

1

0

High-throughput

0.279

Low

280943

HYPM
Huntingtin-interacting protein M

1

0

High-throughput

0.279

Low

471160

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.279

Low

889477

CLK1
Dual specificity protein kinase CLK1

1

0

High-throughput

0.279

Low

1368753

DNAI2
Dynein axonemal intermediate chain 2

1

0

High-throughput

0.279

Low

1368777

PSG11
Pregnancy-specific beta-1-glycoprotein 11

1

0

High-throughput

0.279

Low

441559

CCKN
Cholecystokinin

1

0

High-throughput

0.268

Low

85293

RBG10
Rab GTPase-activating protein 1-like, isoform 10

1

0

Small-scale

0.249

Low

106391

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

848420

MAGA6
Melanoma-associated antigen 6

1

0

High-throughput

0.249

Low

1276578

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1358011

TM171
Transmembrane protein 171

1

0

High-throughput

0.249

Low

1368781

SALL2
Sal-like protein 2

1

0

High-throughput

0.249

Low

1253640

PKHG7
Pleckstrin homology domain-containing family G member 7

1

0

High-throughput

0.232

Low

1293881

VSIG1
V-set and immunoglobulin domain-containing protein 1

1

0

High-throughput

0.232

Low

1330785

S35G3
Solute carrier family 35 member G3

1

0

High-throughput

0.232

Low

1368741

C170L
Cep170-like protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025