HitPredict

Interactor 1: EIF3I (Q13347)
Eukaryotic translation initiation factor 3 subunit I (eIF3i) (Eukaryotic translation initiation factor 3 subunit 2) (TGF-beta receptor-interacting protein 1) (TRIP-1) (eIF-3-beta) (eIF3 p36)
Gene: EIF3I

Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35563538, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 325 Hs			1 768
+	Hs
		197016 PRP4_HUMAN (95-325): 1.03e-46: 166: 11.67		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		903207 WDR5_HUMAN (180-325): 1.26e-38: 141: 15.65		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1032086 EIF3I_HUMAN (1-325): 3.67e-93: 281: 100.00		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		1042101 POC1B_HUMAN (226-325): 7.26e-14: 73.9: 21.78		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042903 STRAP_HUMAN (186-316): 4.07e-09: 58.9: 20.15		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		903208 WDR5_HUMAN (180-325): 1.26e-38: 141: 15.65		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		1043085 WDR5B_HUMAN (180-325): 2.45e-34: 129: 13.61		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		903209 WDR5_HUMAN (180-325): 1.26e-38: 141: 15.65		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		1043441 WDR5B_HUMAN (180-325): 2.45e-34: 129: 13.61		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		1043064 BRWD3_HUMAN (65-317): 2.08e-26: 112: 15.72		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		1043157 SNR40_HUMAN (3-122): 1.87e-26: 108: 20.93		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		1043417 BRWD3_HUMAN (65-317): 2.08e-26: 112: 15.72		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		1043509 SNR40_HUMAN (3-122): 1.87e-26: 108: 20.93		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		792982 LIS1_HUMAN (1-82): 2.95e-21: 95.1: 25.61		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		1043114 POC1B_HUMAN (226-325): 7.26e-14: 73.9: 21.78		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		1043469 POC1B_HUMAN (226-325): 7.26e-14: 73.9: 21.78		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		903206 WDR5_HUMAN (180-325): 1.26e-38: 141: 15.65		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		1043499 FBXW7_HUMAN (5-75): 4.23e-09: 59.6: 24.05		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Mm
		1257398 FBXW7_MOUSE (5-75): 2.93e-09: 60: 24.05		CUL1_MOUSE (17-768): 0: 709: 30.53
+	Hs
		1041133 FBXW7_HUMAN (5-75): 4.23e-09: 59.6: 24.05		CUL1_HUMAN (18-768): 0: 707: 30.57