HitPredict

Interactor 1: EWS (Q01844)
RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein)
Gene: EWSR1

Interactor 2: NONO (Q15233)
Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (p54(nrb)) (p54nrb) (55 kDa nuclear protein) (NMT55) (DNA-binding p52/p100 complex, 52 kDa subunit)
Gene: NONO

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	21988832
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	NOPS~RRM_1, RRM_1~RRM_1, RRM_1~zf-RanBP
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006355 - regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 656 Hs			1 471
+	Hs
		1144430 RBP56_HUMAN (109-555): 5.81e-53: 193: 35.05		NONO_HUMAN (1-471): 1.63e-96: 300: 100.00
+	Mm
		1222970 EWS_MOUSE (1-656): 4.64e-42: 163: 94.06		NONO_MOUSE (1-471): 4.76e-93: 291: 98.31
+	Hs
		550392 RBP56_HUMAN (109-555): 5.81e-53: 193: 35.05		PABP1_HUMAN (66-459): 4.75e-67: 228: 14.52
+	Mm
		1297233 Q8BQ46_MOUSE (109-555): 4.72e-53: 193: 35.35		PSPC1_MOUSE (20-470): 1.01e-66: 224: 56.29
+	Hs
		655288 RBP56_HUMAN (109-555): 5.81e-53: 193: 35.05		SFPQ_HUMAN (45-471): 2.56e-54: 195: 58.73
+	Mm
		1222959 EWS_MOUSE (1-656): 4.64e-42: 163: 94.06		PSPC1_MOUSE (20-470): 1.01e-66: 224: 56.29
+	Hs
		686612 EWS_HUMAN (1-656): 1.53e-47: 179: 100.00		ELAV4_HUMAN (40-205): 3.55e-60: 203: 28.02
+	Hs
		341637 EYA4_HUMAN (3-271): 6.1e-39: 154: 18.02		PSPC1_HUMAN (20-470): 4.71e-67: 225: 58.41
+	Hs
		655159 EWS_HUMAN (1-656): 1.53e-47: 179: 100.00		SFPQ_HUMAN (45-471): 2.56e-54: 195: 58.73
+	Hs
		1152570 RBP56_HUMAN (109-555): 5.81e-53: 193: 35.05		ELAV1_HUMAN (68-205): 7.41e-47: 166: 27.82
+	Hs
		1102042 RBP56_HUMAN (109-555): 5.81e-53: 193: 35.05		PABP4_HUMAN (29-439): 1.21e-42: 161: 12.07
+	Hs
		1032961 EWS_HUMAN (1-656): 1.53e-47: 179: 100.00		ELAV3_HUMAN (54-270): 2.37e-48: 171: 22.46
+	Hs
		341522 EYA4_HUMAN (3-271): 6.1e-39: 154: 18.02		SFPQ_HUMAN (45-471): 2.56e-54: 195: 58.73
+	Hs
		1032992 EWS_HUMAN (1-656): 1.53e-47: 179: 100.00		ELAV1_HUMAN (68-205): 7.41e-47: 166: 27.82
+	Sc
		403509 HRB1_YEAST (241-452): 4.77e-35: 140: 21.76		PABP_YEAST (55-284): 1.16e-36: 144: 21.07
+	Mm
		1297232 Q8BQ46_MOUSE (109-555): 4.72e-53: 193: 35.35		RBM4_MOUSE (75-182): 5.45e-09: 59.7: 35.71
+	Hs
		726754 EWS_HUMAN (1-656): 1.53e-47: 179: 100.00		TIA1_HUMAN (142-469): 3.69e-12: 69.6: 12.63
+	Hs
		341618 EYA4_HUMAN (3-271): 6.1e-39: 154: 18.02		RAVR1_HUMAN (76-221): 8.38e-12: 69.4: 24.70
+	Hs
		341663 EYA4_HUMAN (3-271): 6.1e-39: 154: 18.02		RBM4B_HUMAN (75-182): 7.13e-09: 59.3: 35.71
+	Hs
		341667 EYA4_HUMAN (3-271): 6.1e-39: 154: 18.02		RBM4_HUMAN (75-182): 7.68e-09: 59.3: 35.71