Protein: EYA4
Protein phosphatase EYA4 (EC 3.1.3.48) (Eyes absent homolog 4)

Gene: EYA4
Organism: Homo sapiens
Interactions: 247
UniProt ID: O95677

Gene Ontology (top 5):
GO:0004725 - protein tyrosine phosphatase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0006281 - DNA repair
GO:0006325 - chromatin organization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

341573

SIX1
Homeobox protein SIX1

5

20

High-throughput

0.915

High

341684

SIX2
Homeobox protein SIX2

3

20

High-throughput

0.861

High

341699

SIX4
Homeobox protein SIX4

2

20

High-throughput

0.789

High

341498

EYA4
Protein phosphatase EYA4

2

16

High-throughput

0.754

High

341621

SIX5
Homeobox protein SIX5

1

20

High-throughput

0.691

High

341526

MK01
Mitogen-activated protein kinase 1

2

2

Small-scale

0.634

High

341675

DCTP1
dCTP pyrophosphatase 1

3

0

High-throughput

0.628

High

124565

EYA2
Protein phosphatase EYA2

1

14

High-throughput

0.618

High

341657

EYA1
Protein phosphatase EYA1

1

18

High-throughput

0.618

High

341676

AT133
Polyamine-transporting ATPase 13A3

1

3

High-throughput

0.618

High

341698

PFD2
Prefoldin subunit 2

2

3

High-throughput

0.611

High

341654

CIC
Protein capicua homolog

2

20

High-throughput

0.584

High

341540

PLK1
Serine/threonine-protein kinase PLK1

1

7

High-throughput

0.578

High

341612

TRI69
E3 ubiquitin-protein ligase TRIM69

1

1

Small-scale

0.561

High

130343

SPT5H
Transcription elongation factor SPT5

1

14

High-throughput

0.536

High

341512

PIP
Prolactin-inducible protein

1

1

High-throughput

0.536

High

341518

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.536

High

341529

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.536

High

341614

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

6

High-throughput

0.536

High

341693

FOXJ2
Forkhead box protein J2

1

9

High-throughput

0.536

High

228775

SCO2
Protein SCO2 homolog, mitochondrial

2

3

High-throughput

0.533

High

296178

SCO1
Protein SCO1 homolog, mitochondrial

2

3

High-throughput

0.533

High

341501

CRYAA
Alpha-crystallin A chain

1

3

High-throughput

0.501

High

341511

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

High-throughput

0.501

High

341519

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

13

High-throughput

0.494

High

341602

LMTK1
Serine/threonine-protein kinase LMTK1

1

18

High-throughput

0.494

High

67986

SOBP
Sine oculis-binding protein homolog

1

8

High-throughput

0.479

High

129629

CBX4
E3 SUMO-protein ligase CBX4

1

7

High-throughput

0.479

High

136039

PLK4
Serine/threonine-protein kinase PLK4

1

5

High-throughput

0.479

High

142774

NFIB
Nuclear factor 1 B-type

1

17

High-throughput

0.479

High

169872

AURKA
Aurora kinase A

1

2

High-throughput

0.479

High

174292

ZN609
Zinc finger protein 609

1

10

High-throughput

0.479

High

185318

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

9

High-throughput

0.479

High

239909

SOX15
Transcription factor SOX-15

1

20

High-throughput

0.479

High

287749

MED6
Mediator of RNA polymerase II transcription subunit 6

1

2

High-throughput

0.479

High

296945

CCNK
Cyclin-K

1

7

High-throughput

0.479

High

320852

LRIG2
Leucine-rich repeats and immunoglobulin-like domains protein 2

1

2

High-throughput

0.479

High

340552

CNOT4
CCR4-NOT transcription complex subunit 4

1

1

High-throughput

0.479

High

341499

BAG3
BAG family molecular chaperone regulator 3

1

2

High-throughput

0.479

High

341500

RASK
GTPase KRas

1

9

Small-scale

0.479

High

341502

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

Small-scale

0.479

High

341503

HSPB1
Heat shock protein beta-1

1

3

High-throughput

0.479

High

341504

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

5

High-throughput

0.479

High

341505

JUN
Transcription factor Jun

1

10

High-throughput

0.479

High

341506

K2C8
Keratin, type II cytoskeletal 8

1

1

High-throughput

0.479

High

341507

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

341508

RU1C
U1 small nuclear ribonucleoprotein C

1

4

High-throughput

0.479

High

341509

ATX1L
Ataxin-1-like

1

1

High-throughput

0.479

High

341516

ITF2
Transcription factor 4

1

1

High-throughput

0.479

High

341517

TFE2
Transcription factor E2-alpha

1

1

High-throughput

0.479

High

341521

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

18

Small-scale

0.479

High

341522

SFPQ
Splicing factor, proline- and glutamine-rich

1

13

High-throughput

0.479

High

341523

GATA2
Endothelial transcription factor GATA-2

1

10

High-throughput

0.479

High

341524

MK03
Mitogen-activated protein kinase 3

1

2

Small-scale

0.479

High

341525

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

3

High-throughput

0.479

High

341528

TLX1
T-cell leukemia homeobox protein 1

1

16

High-throughput

0.479

High

341531

HNF1B
Hepatocyte nuclear factor 1-beta

1

20

High-throughput

0.479

High

341532

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

3

Small-scale

0.479

High

341534

GPX4
Phospholipid hydroperoxide glutathione peroxidase GPX4

1

1

High-throughput

0.479

High

341535

CRKL
Crk-like protein

1

3

High-throughput

0.479

High

341536

KC1A
Casein kinase I isoform alpha

1

3

High-throughput

0.479

High

341537

KC1E
Casein kinase I isoform epsilon

1

3

High-throughput

0.479

High

341539

TF2AA
Transcription initiation factor IIA subunit 1

1

1

High-throughput

0.479

High

341541

ATN1
Atrophin-1

1

20

High-throughput

0.479

High

341542

GSC
Homeobox protein goosecoid

1

11

High-throughput

0.479

High

341544

PFD3
Prefoldin subunit 3

1

1

High-throughput

0.479

High

341546

RUXE
Small nuclear ribonucleoprotein E

1

1

High-throughput

0.479

High

341547

H4
Histone H4

1

5

High-throughput

0.479

High

341549

GRB2
Growth factor receptor-bound protein 2

1

6

High-throughput

0.479

High

341550

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

5

High-throughput

0.479

High

341551

IF5A1
Eukaryotic translation initiation factor 5A-1

1

3

High-throughput

0.479

High

341552

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

2

High-throughput

0.479

High

341553

TIAR
Nucleolysin TIAR

1

7

High-throughput

0.479

High

341554

EWS
RNA-binding protein EWS

1

18

High-throughput

0.479

High

341555

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

3

Small-scale

0.479

High

341556

ERCC6
DNA excision repair protein ERCC-6

1

16

Small-scale

0.479

High

341557

LGUL
Lactoylglutathione lyase

1

1

High-throughput

0.479

High

341558

TLE5
TLE family member 5

1

6

High-throughput

0.479

High

341559

EP300
Histone acetyltransferase p300

1

20

High-throughput

0.479

High

341561

CDC20
Cell division cycle protein 20 homolog

1

16

High-throughput

0.479

High

341562

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

341563

TRI32
E3 ubiquitin-protein ligase TRIM32

1

2

High-throughput

0.479

High

341564

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

1

High-throughput

0.479

High

341565

GPS2
G protein pathway suppressor 2

1

1

High-throughput

0.479

High

341567

FHL3
Four and a half LIM domains protein 3

1

4

High-throughput

0.479

High

341569

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

341572

SF3B4
Splicing factor 3B subunit 4

1

9

High-throughput

0.479

High

341574

NCOA2
Nuclear receptor coactivator 2

1

7

High-throughput

0.479

High

341575

SF01
Splicing factor 1

1

12

High-throughput

0.479

High

341577

TRIP6
Thyroid receptor-interacting protein 6

1

2

High-throughput

0.479

High

341578

NCOA1
Nuclear receptor coactivator 1

1

6

High-throughput

0.479

High

341579

TAF9
Transcription initiation factor TFIID subunit 9

1

2

High-throughput

0.479

High

341580

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

20

High-throughput

0.479

High

341582

RFX7
DNA-binding protein RFX7

1

10

High-throughput

0.479

High

341585

GRDN
Girdin

1

4

High-throughput

0.479

High

341588

AMOT
Angiomotin

1

9

High-throughput

0.479

High

341590

PRC2B
Protein PRRC2B

1

20

High-throughput

0.479

High

341596

TET2
Methylcytosine dioxygenase TET2

1

1

High-throughput

0.479

High

341597

MED27
Mediator of RNA polymerase II transcription subunit 27

1

1

High-throughput

0.479

High

341600

WDR74
WD repeat-containing protein 74

1

17

High-throughput

0.479

High

341601

BCOR
BCL-6 corepressor

1

10

High-throughput

0.479

High

341604

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.479

High

341605

UBN2
Ubinuclein-2

1

13

High-throughput

0.479

High

341606

MCM10
Protein MCM10 homolog

1

1

High-throughput

0.479

High

341608

KHDC4
KH homology domain-containing protein 4

1

1

High-throughput

0.479

High

341609

LDB1
LIM domain-binding protein 1

1

1

High-throughput

0.479

High

341610

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

12

High-throughput

0.479

High

341611

LUZP1
Leucine zipper protein 1

1

9

High-throughput

0.479

High

341615

TPPC5
Trafficking protein particle complex subunit 5

1

1

High-throughput

0.479

High

341616

ZC3H3
Zinc finger CCCH domain-containing protein 3

1

3

High-throughput

0.479

High

341618

RAVR1
Ribonucleoprotein PTB-binding 1

1

13

High-throughput

0.479

High

341620

PELP1
Proline-, glutamic acid- and leucine-rich protein 1

1

16

High-throughput

0.479

High

341627

ZMIZ2
Zinc finger MIZ domain-containing protein 2

1

7

High-throughput

0.479

High

341629

PUM2
Pumilio homolog 2

1

3

High-throughput

0.479

High

341633

SP7
Transcription factor Sp7

1

20

High-throughput

0.479

High

341637

PSPC1
Paraspeckle component 1

1

17

High-throughput

0.479

High

341638

AUTS2
Autism susceptibility gene 2 protein

1

20

High-throughput

0.479

High

341639

MAML1
Mastermind-like protein 1

1

16

High-throughput

0.479

High

341640

CBP
CREB-binding protein

1

15

High-throughput

0.479

High

341644

DAZP1
DAZ-associated protein 1

1

10

High-throughput

0.479

High

341646

RBM33
RNA-binding protein 33

1

20

High-throughput

0.479

High

341647

ZN503
Zinc finger protein 503

1

2

High-throughput

0.479

High

341650

RBM14
RNA-binding protein 14

1

9

High-throughput

0.479

High

341651

QKI
KH domain-containing RNA-binding protein QKI

1

9

High-throughput

0.479

High

341655

MED15
Mediator of RNA polymerase II transcription subunit 15

1

18

High-throughput

0.479

High

341659

PITX2
Pituitary homeobox 2

1

10

High-throughput

0.479

High

341661

ANM1
Protein arginine N-methyltransferase 1

1

8

High-throughput

0.479

High

341662

PKP2
Plakophilin-2

1

2

High-throughput

0.479

High

341664

TCHP
Trichoplein keratin filament-binding protein

1

3

High-throughput

0.479

High

341665

RBM42
RNA-binding protein 42

1

7

High-throughput

0.479

High

341667

RBM4
RNA-binding protein 4

1

13

High-throughput

0.479

High

341669

SSBP3
Single-stranded DNA-binding protein 3

1

13

High-throughput

0.479

High

341670

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

8

High-throughput

0.479

High

341671

TRI31
E3 ubiquitin-protein ligase TRIM31

1

8

High-throughput

0.479

High

341672

WDR33
pre-mRNA 3' end processing protein WDR33

1

13

High-throughput

0.479

High

341674

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

341677

ZN703
Zinc finger protein 703

1

6

High-throughput

0.479

High

341678

VP37B
Vacuolar protein sorting-associated protein 37B

1

4

High-throughput

0.479

High

341680

SENP2
Sentrin-specific protease 2

1

1

High-throughput

0.479

High

341691

BICRA
BRD4-interacting chromatin-remodeling complex-associated protein

1

20

High-throughput

0.479

High

341695

PEF1
Peflin

1

4

High-throughput

0.479

High

341696

UBQL2
Ubiquilin-2

1

10

High-throughput

0.479

High

341700

ANC2
Anaphase-promoting complex subunit 2

1

12

High-throughput

0.479

High

341701

ZN608
Zinc finger protein 608

1

9

High-throughput

0.479

High

341702

ZMIZ1
Zinc finger MIZ domain-containing protein 1

1

5

High-throughput

0.479

High

341703

PRR12
Proline-rich protein 12

1

20

High-throughput

0.479

High

341704

CIZ1
Cip1-interacting zinc finger protein

1

6

High-throughput

0.479

High

341707

FOXJ3
Forkhead box protein J3

1

11

High-throughput

0.479

High

341708

R3HD2
R3H domain-containing protein 2

1

16

High-throughput

0.479

High

341712

MAGD1
Melanoma-associated antigen D1

1

4

High-throughput

0.479

High

341713

NCOR2
Nuclear receptor corepressor 2

1

13

High-throughput

0.479

High

341715

NCOA3
Nuclear receptor coactivator 3

1

7

High-throughput

0.479

High

183318

ZN185
Zinc finger protein 185

1

0

High-throughput

0.458

High

219061

RA51C
DNA repair protein RAD51 homolog 3

1

0

High-throughput

0.458

High

228135

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.458

High

325456

CCNB2
G2/mitotic-specific cyclin-B2

1

0

High-throughput

0.458

High

329882

ZWINT
Outer kinetochore KNL1 complex subunit ZWINT

1

0

High-throughput

0.458

High

341513

UNG
Uracil-DNA glycosylase

1

0

High-throughput

0.458

High

341515

GLNA
Glutamine synthetase

1

0

High-throughput

0.458

High

341520

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.458

High

341533

HEM6
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial

1

0

High-throughput

0.458

High

341538

BRCA2
Breast cancer type 2 susceptibility protein

1

0

High-throughput

0.458

High

341543

MLF1
Myeloid leukemia factor 1

1

0

High-throughput

0.458

High

341545

UFM1
Ubiquitin-fold modifier 1

1

0

High-throughput

0.458

High

341548

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

0

High-throughput

0.458

High

341560

TROAP
Tastin

1

0

High-throughput

0.458

High

341566

ATR
Serine/threonine-protein kinase ATR

1

0

High-throughput

0.458

High

341587

TPRN
Taperin

1

0

High-throughput

0.458

High

341607

HDX
Highly divergent homeobox

1

0

High-throughput

0.458

High

341622

HROB
Homologous recombination OB-fold protein

1

0

High-throughput

0.458

High

341631

DC2L1
Cytoplasmic dynein 2 light intermediate chain 1

1

0

High-throughput

0.458

High

341632

URGCP
Up-regulator of cell proliferation

1

0

High-throughput

0.458

High

341649

CEP20
Centrosomal protein 20

1

0

High-throughput

0.458

High

341656

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.458

High

341660

CTIP
DNA endonuclease RBBP8

1

0

High-throughput

0.458

High

341666

MCRI2
MAPK regulated corepressor interacting protein 2

1

0

High-throughput

0.458

High

341668

SCNM1
Sodium channel modifier 1

1

0

High-throughput

0.458

High

341682

RESF1
Retroelement silencing factor 1

1

0

High-throughput

0.458

High

341685

GEPH
Gephyrin [Includes: Molybdopterin adenylyltransferase

1

0

High-throughput

0.458

High

341686

LANC2
LanC-like protein 2

1

0

High-throughput

0.458

High

341688

PDRG1
p53 and DNA damage-regulated protein 1

1

0

High-throughput

0.458

High

341689

SPS2L
SPATS2-like protein

1

0

High-throughput

0.458

High

341694

VPS29
Vacuolar protein sorting-associated protein 29

1

0

High-throughput

0.458

High

341697

IP6K2
Inositol hexakisphosphate kinase 2

1

0

High-throughput

0.458

High

341705

SPAT2
Spermatogenesis-associated protein 2

1

0

High-throughput

0.458

High

341709

UTP11
Probable U3 small nucleolar RNA-associated protein 11

1

0

High-throughput

0.458

High

91819

KBTBD
Kelch repeat and BTB domain-containing protein 13

1

3

High-throughput

0.437

High

138956

BCL9
B-cell CLL/lymphoma 9 protein

1

19

High-throughput

0.437

High

176434

GRRE1
Granule associated Rac and RHOG effector protein 1

1

1

High-throughput

0.437

High

213549

VIP2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

1

1

High-throughput

0.437

High

281702

VP26A
Vacuolar protein sorting-associated protein 26A

1

2

High-throughput

0.437

High

291166

NU155
Nuclear pore complex protein Nup155

1

1

High-throughput

0.437

High

338388

SC24B
Protein transport protein Sec24B

1

10

High-throughput

0.437

High

341510

CTF8
Chromosome transmission fidelity protein 8 homolog

1

1

High-throughput

0.437

High

341530

SOAT1
Sterol O-acyltransferase 1

1

1

High-throughput

0.437

High

341568

GSE1
Genetic suppressor element 1

1

2

High-throughput

0.437

High

341570

R3HD1
R3H domain-containing protein 1

1

17

High-throughput

0.437

High

341571

PLEC
Plectin

1

3

High-throughput

0.437

High

341576

JHD2C
Probable JmjC domain-containing histone demethylation protein 2C

1

1

High-throughput

0.437

High

341583

QSER1
Glutamine and serine-rich protein 1

1

19

High-throughput

0.437

High

341584

AAK1
AP2-associated protein kinase 1

1

6

High-throughput

0.437

High

341586

VP26B
Vacuolar protein sorting-associated protein 26B

1

2

High-throughput

0.437

High

341592

RC3H1
Roquin-1

1

3

High-throughput

0.437

High

341593

DDI2
Protein DDI1 homolog 2

1

8

High-throughput

0.437

High

341594

WDR25
WD repeat-containing protein 25

1

13

High-throughput

0.437

High

341595

SPT2
Protein SPT2 homolog

1

13

High-throughput

0.437

High

341598

CEP85
Centrosomal protein of 85 kDa

1

6

High-throughput

0.437

High

341599

MDEAS
Mitotic deacetylase-associated SANT domain protein

1

6

High-throughput

0.437

High

341603

CO039
Uncharacterized protein C15orf39

1

11

High-throughput

0.437

High

341613

PRSR1
Proline and serine-rich protein 1

1

12

High-throughput

0.437

High

341617

AMOL1
Angiomotin-like protein 1

1

9

High-throughput

0.437

High

341623

TAB3
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

1

16

High-throughput

0.437

High

341625

MISSL
MAPK-interacting and spindle-stabilizing protein-like

1

10

High-throughput

0.437

High

341626

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

18

High-throughput

0.437

High

341630

ALMS1
Centrosome-associated protein ALMS1

1

13

High-throughput

0.437

High

341635

POF1B
Protein POF1B

1

1

High-throughput

0.437

High

341636

ATX2L
Ataxin-2-like protein

1

17

High-throughput

0.437

High

341641

DVL3
Segment polarity protein dishevelled homolog DVL-3

1

5

High-throughput

0.437

High

341642

KCD12
BTB/POZ domain-containing protein KCTD12

1

5

High-throughput

0.437

High

341643

SEH1
Nucleoporin SEH1

1

18

High-throughput

0.437

High

341663

RBM4B
RNA-binding protein 4B

1

12

High-throughput

0.437

High

341679

FBRS
Probable fibrosin-1

1

3

High-throughput

0.437

High

341681

TNR6C
Trinucleotide repeat-containing gene 6C protein

1

20

High-throughput

0.437

High

341683

FBSL
Fibrosin-1-like protein

1

3

High-throughput

0.437

High

341687

RBM12
RNA-binding protein 12

1

8

High-throughput

0.437

High

341690

CARF
CDKN2A-interacting protein

1

1

High-throughput

0.437

High

341692

NDUF4
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

1

1

High-throughput

0.437

High

341706

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

10

High-throughput

0.437

High

341714

ORNT1
Mitochondrial ornithine transporter 1

1

1

High-throughput

0.437

High

341514

YJU2B
Probable splicing factor YJU2B

1

0

High-throughput

0.249

Low

341527

PUR8
Adenylosuccinate lyase

1

0

High-throughput

0.249

Low

341581

VATF
V-type proton ATPase subunit F

1

0

High-throughput

0.249

Low

341589

COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

1

0

High-throughput

0.249

Low

341591

EOGT
EGF domain-specific O-linked N-acetylglucosamine transferase

1

0

High-throughput

0.249

Low

341619

CKP2L
Cytoskeleton-associated protein 2-like

1

0

High-throughput

0.249

Low

341624

MTMRE
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14

1

0

High-throughput

0.249

Low

341628

FAD1
FAD synthase

1

0

High-throughput

0.249

Low

341634

F222B
Protein FAM222B

1

0

High-throughput

0.249

Low

341645

RRP36
Ribosomal RNA processing protein 36 homolog

1

0

High-throughput

0.249

Low

341648

CC120
Coiled-coil domain-containing protein 120

1

0

High-throughput

0.249

Low

341652

UIF
UAP56-interacting factor

1

0

High-throughput

0.249

Low

341653

VPS35
Vacuolar protein sorting-associated protein 35

1

0

High-throughput

0.249

Low

341658

MPP9
M-phase phosphoprotein 9

1

0

High-throughput

0.249

Low

341673

FN3K
Fructosamine-3-kinase

1

0

High-throughput

0.249

Low

341710

CHTOP
Chromatin target of PRMT1 protein

1

0

High-throughput

0.249

Low

341711

LRC42
Leucine-rich repeat-containing protein 42

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025