HitPredict

Interactor 1: SNTB2 (Q13425)
Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin-3) (SNT3) (Syntrophin-like) (SNTL)
Gene: SNTB2

Interactor 2: KS6A1 (Q15418)
Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1)
Gene: RPS6KA1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	31678930, 36736316
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Pkinase
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0045202 - synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 540 Hs			1 735
+	Hs
		1046432 SNTB1_HUMAN (24-539): 2.43e-151: 445: 55.30		KS6A1_HUMAN (1-735): 0: 836: 100.00
+	Hs
		850649 SNTB2_HUMAN (18-540): 1.13e-164: 480: 100.00		KS6A3_HUMAN (1-735): 0: 791: 79.14
+	Hs
		1033837 SNTA1_HUMAN (16-539): 1.35e-142: 422: 45.49		KS6A1_HUMAN (1-735): 0: 836: 100.00
+	Hs
		1073488 SNTG2_HUMAN (103-536): 2.07e-110: 341: 24.04		KS6A1_HUMAN (1-735): 0: 836: 100.00
+	Hs
		272861 SNTB2_HUMAN (18-540): 1.13e-164: 480: 100.00		KS6A4_HUMAN (49-734): 0: 649: 41.33
+	Hs
		1073484 GOPC_HUMAN (92-199): 1.67e-34: 137: 39.82		KS6A1_HUMAN (1-735): 0: 836: 100.00
+	Hs
		942348 DLG4_HUMAN (66-394): 4.83e-27: 117: 16.02		KS6A1_HUMAN (1-735): 0: 836: 100.00
+	Hs
		850715 GOPC_HUMAN (92-199): 1.67e-34: 137: 39.82		KS6A3_HUMAN (1-735): 0: 791: 79.14
+	Hs
		1073495 PZRN3_HUMAN (7-198): 8.64e-16: 83: 14.35		KS6A1_HUMAN (1-735): 0: 836: 100.00
+	Hs
		1073470 MAGI1_HUMAN (69-261): 1.09e-15: 82.6: 17.96		KS6A1_HUMAN (1-735): 0: 836: 100.00
+	Hs
		1073438 PZRN4_HUMAN (55-202): 6.15e-14: 76.8: 19.08		KS6A1_HUMAN (1-735): 0: 836: 100.00
+	Hs
		117238 PDLI1_HUMAN (117-417): 7.37e-46: 165: 15.02		KS6A5_HUMAN (46-730): 0: 706: 41.42
+	Hs
		647885 SNTB2_HUMAN (18-540): 1.13e-164: 480: 100.00		MARK3_HUMAN (408-695): 1.9e-108: 348: 28.48
+	Hs
		568658 SNTB1_HUMAN (24-539): 2.43e-151: 445: 55.30		KAPCA_HUMAN (414-712): 3.66e-114: 350: 29.71
+	Hs
		647889 SNTB1_HUMAN (24-539): 2.43e-151: 445: 55.30		MARK3_HUMAN (408-695): 1.9e-108: 348: 28.48
+	Hs
		272903 GOPC_HUMAN (92-199): 1.67e-34: 137: 39.82		KS6A4_HUMAN (49-734): 0: 649: 41.33
+	Mm
		933108 DLG4_MOUSE (66-394): 4.96e-27: 117: 16.32		KAPCB_MOUSE (416-712): 7.52e-113: 346: 29.90
+	Hs
		1071704 GOPC_HUMAN (92-199): 1.67e-34: 137: 39.82		KS6A2_HUMAN (2-321): 2.57e-98: 321: 23.80
+	Mm
		1143553 DLG4_MOUSE (66-394): 4.96e-27: 117: 16.32		KS6A2_MOUSE (2-331): 2.44e-102: 332: 23.68
+	Hs
		1021498 DLG1_HUMAN (2-419): 1.78e-27: 119: 15.51		KS6A2_HUMAN (2-321): 2.57e-98: 321: 23.80