HitPredict

Interactor 1: FKBP5 (Q13451)
Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)
Gene: FKBP5

Interactor 2: NEK11 (Q8NG66)
Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (Never in mitosis A-related kinase 11) (NimA-related protein kinase 11)
Gene: NEK11

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FKBP_C~Pkinase
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 457 Hs			1 645
+	Hs
		1034842 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		KCC2G_HUMAN (18-560): 4.11e-135: 409: 17.79
+	Hs
		1034968 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		MARK4_HUMAN (6-593): 1.67e-130: 403: 16.80
+	Hs
		682173 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		AKT2_HUMAN (4-359): 1.82e-132: 399: 19.06
+	Hs
		1035058 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		AKT3_HUMAN (5-359): 1.01e-131: 397: 21.33
+	Hs
		681830 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		AKT1_HUMAN (4-354): 4.58e-128: 387: 19.83
+	Hs
		1034843 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		KCC2D_HUMAN (18-435): 1.16e-123: 377: 19.77
+	Hs
		851484 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		NEK4_HUMAN (29-291): 4.98e-61: 220: 43.02
+	Hs
		1053085 FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23		NEK11_HUMAN (1-645): 3.65e-171: 504: 100.00
+	Hs
		972538 FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59		NEK8_HUMAN (28-294): 5.75e-47: 178: 36.06
+	Hs
		972555 FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59		NEK7_HUMAN (29-284): 1.32e-46: 168: 34.35
+	Hs
		972532 FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59		NEK10_HUMAN (29-306): 9.52e-31: 130: 30.87
+	Hs
		1053253 FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23		KCC2A_HUMAN (17-470): 5.16e-122: 372: 20.56
+	Hs
		684698 STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62		KCC2D_HUMAN (18-435): 1.16e-123: 377: 19.77
+	Hs
		932943 FKB1B_HUMAN (41-138): 1.43e-24: 99.4: 50.00		KCC2D_HUMAN (18-435): 1.16e-123: 377: 19.77
+	Hs
		118758 AIP_HUMAN (144-414): 1.52e-49: 173: 16.72		NEK8_HUMAN (28-294): 5.75e-47: 178: 36.06
+	Hs
		684848 STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62		NEK8_HUMAN (28-294): 5.75e-47: 178: 36.06
+	Hs
		684908 STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62		NEK9_HUMAN (29-294): 1.53e-40: 160: 34.20
+	Hs
		684829 STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62		NEK10_HUMAN (29-306): 9.52e-31: 130: 30.87