Protein: CBLC
E3 ubiquitin-protein ligase CBL-C (EC 2.3.2.27) (RING finger protein 57) (RING-type E3 ubiquitin transferase CBL-C) (SH3-binding protein CBL-3) (SH3-binding protein CBL-C) (Signal transduction protein CBL-C)

Gene: CBLC
Organism: Homo sapiens
Interactions: 81
UniProt ID: Q9ULV8

Gene Ontology (top 5):
GO:0001784 - phosphotyrosine residue binding
GO:0005154 - epidermal growth factor receptor binding
GO:0005509 - calcium ion binding
GO:0005886 - plasma membrane
GO:0006511 - ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

957690

UBE2K
Ubiquitin-conjugating enzyme E2 K

2

20

High-throughput

0.783

High

982365

UB2D2
Ubiquitin-conjugating enzyme E2 D2

2

20

Small-scale

0.778

High

364018

EGFR
Epidermal growth factor receptor

5

20

Small-scale

0.721

High

168578

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

1

20

High-throughput

0.698

High

971280

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

20

High-throughput

0.698

High

993810

UBC9
SUMO-conjugating enzyme UBC9

1

20

High-throughput

0.698

High

996042

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

20

High-throughput

0.698

High

1107503

BIRC2
Baculoviral IAP repeat-containing protein 2

1

1

High-throughput

0.698

High

1258831

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

20

High-throughput

0.698

High

1414803

TRAF4
TNF receptor-associated factor 4

1

9

High-throughput

0.698

High

557519

SRC
Proto-oncogene tyrosine-protein kinase Src

3

20

Small-scale

0.676

High

855801

CRK
Adapter molecule crk

3

20

Small-scale

0.651

High

179748

MDM4
Protein Mdm4

1

1

High-throughput

0.647

High

508823

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

16

Small-scale

0.647

High

710566

EPHA2
Ephrin type-A receptor 2

1

18

High-throughput

0.647

High

906825

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

20

Small-scale

0.647

High

957240

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

20

Small-scale

0.647

High

1372019

LPP
Lipoma-preferred partner

2

10

High-throughput

0.628

High

1452522

ABI2
Abl interactor 2

2

20

High-throughput

0.628

High

1461780

WASF2
Actin-binding protein WASF2

2

1

High-throughput

0.628

High

463259

YES
Tyrosine-protein kinase Yes

2

20

High-throughput

0.606

High

1460073

ZNHI2
Zinc finger HIT domain-containing protein 2

2

0

High-throughput

0.602

High

1461778

NCKP1
Nck-associated protein 1

2

0

High-throughput

0.602

High

212741

TGFI1
Transforming growth factor beta-1-induced transcript 1 protein

3

8

Small-scale

0.600

High

1394638

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

7

Small-scale

0.586

High

464077

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

2

20

Small-scale

0.584

High

171785

GAK
Cyclin-G-associated kinase

2

1

High-throughput

0.574

High

1272224

CYFP1
Cytoplasmic FMR1-interacting protein 1

2

1

High-throughput

0.574

High

1364471

WASF1
Actin-binding protein WASF1

2

2

High-throughput

0.574

High

1390224

CYFP2
Cytoplasmic FMR1-interacting protein 2

2

1

High-throughput

0.574

High

440783

FYN
Tyrosine-protein kinase Fyn

1

20

Small-scale

0.561

High

1278505

TRI46
Tripartite motif-containing protein 46

1

5

High-throughput

0.541

High

1389451

CHFR
E3 ubiquitin-protein ligase CHFR

1

2

High-throughput

0.541

High

1364678

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.536

High

75541

B3KSH4
Huntingtin interacting protein 2, isoform CRA_a

1

20

High-throughput

0.528

High

711430

SHC1
SHC-transforming protein 1

1

20

High-throughput

0.508

High

1408423

SH3G3
Endophilin-A3

1

20

High-throughput

0.508

High

1447736

PDLI7
PDZ and LIM domain protein 7

1

10

Small-scale

0.504

High

401690

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

12

High-throughput

0.501

High

411114

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.501

High

414837

P53
Cellular tumor antigen p53

1

2

High-throughput

0.501

High

463839

LYN
Tyrosine-protein kinase Lyn

1

20

Small-scale

0.501

High

648732

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.501

High

728478

AKT1
RAC-alpha serine/threonine-protein kinase

1

5

High-throughput

0.501

High

767370

MERL
Merlin

1

2

High-throughput

0.501

High

858728

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

2

High-throughput

0.501

High

1316722

ABI1
Abl interactor 1

1

20

Small-scale

0.501

High

288541

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

5

High-throughput

0.481

High

1151685

TRIP6
Thyroid receptor-interacting protein 6

1

11

Small-scale

0.481

High

1460943

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

5

High-throughput

0.481

High

162978

TERT
Telomerase reverse transcriptase

1

0

High-throughput

0.480

High

1025437

CDK6
Cyclin-dependent kinase 6

1

0

High-throughput

0.480

High

1154475

STK11
Serine/threonine-protein kinase STK11

1

0

High-throughput

0.480

High

1419522

NSD3
Histone-lysine N-methyltransferase NSD3

1

0

High-throughput

0.480

High

1419626

GLIS2
Zinc finger protein GLIS2

1

0

High-throughput

0.480

High

472146

MET
Hepatocyte growth factor receptor

1

14

Small-scale

0.479

High

1124754

SRC8
Src substrate cortactin

1

20

Small-scale

0.479

High

1461779

CD2AP
CD2-associated protein

1

20

Small-scale

0.479

High

927607

ATX1
Ataxin-1

1

1

High-throughput

0.470

High

1096271

TADBP
TAR DNA-binding protein 43

1

2

High-throughput

0.470

High

176775

NACAD
NAC-alpha domain-containing protein 1

1

1

High-throughput

0.464

High

791832

SYUA
Alpha-synuclein

1

0

High-throughput

0.460

High

373475

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.457

High

445679

KCRM
Creatine kinase M-type

1

1

Small-scale

0.457

High

842940

CDN2B
Cyclin-dependent kinase 4 inhibitor B

1

1

High-throughput

0.457

High

1448713

LATS2
Serine/threonine-protein kinase LATS2

1

3

High-throughput

0.457

High

988025

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.445

High

1154195

ITSN1
Intersectin-1

1

20

High-throughput

0.445

High

1453443

ITSN2
Intersectin-2

1

20

High-throughput

0.445

High

1458285

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

14

High-throughput

0.445

High

170425

AURKA
Aurora kinase A

1

6

Small-scale

0.437

High

1151979

TWST1
Twist-related protein 1

1

2

Small-scale

0.437

High

1391848

AURKB
Aurora kinase B

1

4

Small-scale

0.437

High

849085

ZAP70
Tyrosine-protein kinase ZAP-70

1

20

Small-scale

0.408

High

720813

PUR8
Adenylosuccinate lyase

1

1

High-throughput

0.407

High

1357228

BRK1
Protein BRICK1

2

0

High-throughput

0.328

High

1410891

MGME1
Mitochondrial genome maintenance exonuclease 1

2

0

High-throughput

0.328

High

1141566

OXA1L
Mitochondrial inner membrane protein OXA1L

1

0

High-throughput

0.282

High

474370

NFIC
Nuclear factor 1 C-type

1

0

High-throughput

0.261

Low

718854

CCND2
G1/S-specific cyclin-D2

1

0

High-throughput

0.261

Low

1273067

OTU6A
OTU domain-containing protein 6A

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025