HitPredict

Interactor 1: BIRC3 (Q13489)
Baculoviral IAP repeat-containing protein 3 (EC 2.3.2.27) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (RING-type E3 ubiquitin transferase BIRC3) (TNFR2-TRAF-signaling complex protein 1)
Gene: BIRC3

Interactor 2: MAVS (Q7Z434)
Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA)
Gene: MAVS

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	20097753
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 604 Hs			1 540
+	Hs
		1036288 BIRC2_HUMAN (2-604): 0: 643: 72.31		MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00
+	Hs
		1035854 BIRC3_HUMAN (1-604): 0: 676: 100.00		HUWE1_HUMAN (79-539): 8.05e-24: 108: 13.36
+	Hs
		1035735 BIRC3_HUMAN (1-604): 0: 676: 100.00		MDC1_HUMAN (105-516): 3.47e-10: 65.2: 10.48
+	Hs
		1035796 BIRC3_HUMAN (1-604): 0: 676: 100.00		MGAL_HUMAN (74-498): 6e-09: 61.3: 14.46
+	Hs
		1190044 RNF34_HUMAN (547-604): 6.54e-19: 90.8: 36.21		MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00
+	Hs
		1190049 MIB2_HUMAN (544-603): 2.9e-10: 65.3: 35.00		MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00
+	At
		99090 BOI_ARATH (341-604): 1.71e-36: 140: 17.69		F4K946_ARATH (70-449): 1.07e-11: 69.8: 11.52
+	Hs
		177684 BIRC5_HUMAN (258-332): 1.39e-25: 104: 35.00		MDC1_HUMAN (105-516): 3.47e-10: 65.2: 10.48