Interactor 1: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)
Gene: SQSTM1

Interactor 2: PINK1 (Q9BXM7)
Serine/threonine-protein kinase PINK1, mitochondrial (EC 2.7.11.1) (BRPK) (PTEN-induced putative kinase protein 1)
Gene: PINK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.71 1.00 0.847

The method score is based on:

Property Details
Experiments 30907226, 31300519, 32707033
Identification Methods affinity chromatography technology, pull down
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains PB1~Pkinase
Common GO terms GO:0000422 - autophagy of mitochondrion
GO:0000423 - mitophagy
GO:0002931 - response to ischemia
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
and 8 others

more...

Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 440
Hs

1 581
+ Hs
+ Rn
+ Hs
+ Rn
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Dm
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024