HitPredict

Interactor 1: PRP4K (Q13523)
Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog)
Gene: PRP4K

Interactor 2: SRSF7 (Q16629)
Serine/arginine-rich splicing factor 7 (Splicing factor 9G8) (Splicing factor, arginine/serine-rich 7)
Gene: SRSF7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1007 Hs			1 238
+	Hs
		1037852 PRP4K_HUMAN (1-1007): 1.03e-174: 538: 100.00		PPIL4_HUMAN (1-84): 1.75e-25: 105: 26.97
+	Hs
		853883 PRP4K_HUMAN (1-1007): 1.03e-174: 538: 100.00		NCBP2_HUMAN (10-114): 8.08e-26: 100: 23.42
+	Hs
		432691 PRP4K_HUMAN (1-1007): 1.03e-174: 538: 100.00		HNRPC_HUMAN (3-186): 3e-24: 99: 22.58
+	Hs
		951949 PRP4K_HUMAN (1-1007): 1.03e-174: 538: 100.00		SRSF3_HUMAN (5-154): 2.52e-24: 96.5: 55.33
+	Hs
		992756 PRP4K_HUMAN (1-1007): 1.03e-174: 538: 100.00		SRSF1_HUMAN (10-81): 4.51e-21: 90.3: 48.65
+	Hs
		1037875 PRP4K_HUMAN (1-1007): 1.03e-174: 538: 100.00		RBM4B_HUMAN (12-89): 4.32e-17: 81: 32.05
+	Zm
		33400 A0A1D6L2E7_MAIZE (14-1006): 9.89e-148: 471: 15.38		A0A1D6M1U3_MAIZE (11-132): 2.52e-25: 103: 32.03
+	Hs
		992970 CDK12_HUMAN (31-1005): 5.97e-121: 405: 15.92		SRSF1_HUMAN (10-81): 4.51e-21: 90.3: 48.65
+	Hs
		625466 CDK2_HUMAN (684-955): 5.29e-121: 373: 23.45		SRSF7_HUMAN (1-238): 6.03e-28: 108: 100.00
+	Hs
		853953 DYRK2_HUMAN (565-1007): 1.72e-117: 375: 27.07		NCBP2_HUMAN (10-114): 8.08e-26: 100: 23.42
+	Hs
		432550 CDK2_HUMAN (684-955): 5.29e-121: 373: 23.45		HNRPC_HUMAN (3-186): 3e-24: 99: 22.58
+	Hs
		516362 CDK2_HUMAN (684-955): 5.29e-121: 373: 23.45		PABP1_HUMAN (6-97): 2.16e-19: 88.2: 22.11
+	Zm
		11850 A0A1D6FHK3_MAIZE (687-1005): 7.94e-119: 371: 27.69		A0A1D6II08_MAIZE (7-214): 2.53e-18: 85.1: 13.55
+	Hs
		625590 CDK2_HUMAN (684-955): 5.29e-121: 373: 23.45		RBM4_HUMAN (12-89): 4.44e-14: 72.2: 33.33
+	Sc
		339316 CDK1_YEAST (686-1005): 2.59e-111: 347: 28.27		PABP_YEAST (7-95): 4.44e-17: 81.7: 22.34
+	Hs
		432604 CLK2_HUMAN (670-1002): 2.93e-38: 152: 31.05		HNRPC_HUMAN (3-186): 3e-24: 99: 22.58
+	Hs
		833865 CLK2_HUMAN (670-1002): 2.93e-38: 152: 31.05		SRSF3_HUMAN (5-154): 2.52e-24: 96.5: 55.33
+	Hs
		833870 CLK2_HUMAN (670-1002): 2.93e-38: 152: 31.05		SRSF1_HUMAN (10-81): 4.51e-21: 90.3: 48.65
+	Sc
		376610 YAK1_YEAST (679-1006): 1.71e-39: 160: 33.61		PABP_YEAST (7-95): 4.44e-17: 81.7: 22.34
+	Hs
		516416 CLK2_HUMAN (670-1002): 2.93e-38: 152: 31.05		PABP1_HUMAN (6-97): 2.16e-19: 88.2: 22.11