Protein: CLH
Clathrin heavy chain

Gene: CLH, CHC1
Organism: Saccharomyces cerevisiae S288C
Interactions: 196
UniProt ID: P22137

Gene Ontology (top 5):
GO:0005198 - structural molecule activity
GO:0005829 - cytosol
GO:0006886 - intracellular protein transport
GO:0006895 - Golgi to endosome transport
GO:0006897 - endocytosis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

572023

CLC1
Clathrin light chain

13

7

Small-scale

0.981

High

604404

GGA2
ADP-ribosylation factor-binding protein GGA2

5

16

Small-scale

0.915

High

604486

AP1G1
AP-1 complex subunit gamma-1

2

9

Small-scale

0.793

High

604476

GGA1
ADP-ribosylation factor-binding protein GGA1

2

16

Small-scale

0.768

High

604372

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

5

4

Small-scale

0.723

High

604490

INP53
Polyphosphatidylinositol phosphatase INP53

4

4

Small-scale

0.684

High

604493

ENT1
Epsin-1

4

12

Small-scale

0.683

High

604478

SWA2
Auxilin-like clathrin uncoating factor SWA2

4

8

Small-scale

0.677

High

604492

LAS17
Proline-rich protein LAS17

3

2

Small-scale

0.662

High

604378

SLA2
Protein SLA2

3

11

Small-scale

0.658

High

604370

HSP7F
Heat shock protein homolog SSE1

3

9

High-throughput

0.657

High

490349

HSP71
Heat shock protein SSA1

3

7

High-throughput

0.650

High

604473

ENT2
Epsin-2

3

12

Small-scale

0.646

High

604369

PAN1
Actin cytoskeleton-regulatory complex protein PAN1

3

7

Small-scale

0.641

High

604463

ENT5
Epsin-5

3

11

Small-scale

0.640

High

539947

EI2BA
Translation initiation factor eIF2B subunit alpha

3

0

High-throughput

0.622

High

604387

ALY1
Arrestin-related trafficking adapter 6

1

1

Small-scale

0.618

High

604438

ALY2
Arrestin-related trafficking adapter 3

1

1

Small-scale

0.618

High

604353

SIS1
Protein SIS1

2

1

High-throughput

0.614

High

604384

AP1B1
AP-1 complex subunit beta-1

2

11

Small-scale

0.612

High

604348

HSP74
Heat shock protein SSA4

2

7

High-throughput

0.611

High

604412

END3
Actin cytoskeleton-regulatory complex protein END3

2

8

Small-scale

0.595

High

604371

HSP79
Heat shock protein homolog SSE2

2

10

High-throughput

0.588

High

604389

GBLP
Small ribosomal subunit protein RACK1

2

6

Small-scale

0.584

High

604440

ENT3
Epsin-3

2

11

Small-scale

0.584

High

604426

LYS12
Homoisocitrate dehydrogenase, mitochondrial

2

1

High-throughput

0.567

High

584654

CSK22
Casein kinase II subunit alpha'

1

4

Small-scale

0.561

High

604405

AP18A
Clathrin coat assembly protein AP180A

1

11

Small-scale

0.561

High

604442

BRO1
Vacuolar-sorting protein BRO1

1

1

Small-scale

0.561

High

493209

HSP72
Heat shock protein SSA2

2

7

High-throughput

0.552

High

604428

AGE2
ADP-ribosylation factor GTPase-activating protein effector protein 2

1

4

High-throughput

0.541

High

604458

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

2

High-throughput

0.536

High

604462

GCN5
Histone acetyltransferase GCN5

1

6

High-throughput

0.536

High

604363

VPS10
Vacuolar protein sorting/targeting protein VPS10

1

0

High-throughput

0.518

High

604417

FHP
Flavohemoprotein

1

0

High-throughput

0.518

High

604447

INP52
Polyphosphatidylinositol phosphatase INP52

1

4

Small-scale

0.515

High

604359

AP2B
AP-2 complex subunit beta

1

10

Small-scale

0.501

High

604431

GTS1
Protein GTS1

1

6

Small-scale

0.501

High

604449

AP18B
Clathrin coat assembly protein AP180B

1

13

Small-scale

0.501

High

420226

CALM
Calmodulin

1

1

High-throughput

0.500

High

503047

ARF1
ADP-ribosylation factor 1

1

2

High-throughput

0.500

High

551343

ABP1
Actin-binding protein

1

4

High-throughput

0.500

High

604245

MDHC
Malate dehydrogenase, cytoplasmic

1

2

High-throughput

0.500

High

604350

RFA1
Replication factor A protein 1

1

2

High-throughput

0.500

High

604367

MKK2
MAP kinase kinase MKK2/SSP33

1

7

High-throughput

0.500

High

604392

AP3M
AP-3 complex subunit mu

1

4

High-throughput

0.500

High

604401

KSP1
Serine/threonine-protein kinase KSP1

1

2

High-throughput

0.500

High

604425

PRK1
Actin-regulating kinase PRK1

1

5

High-throughput

0.500

High

604448

UBC13
Ubiquitin-conjugating enzyme E2 13

1

1

High-throughput

0.500

High

604450

SSK2
MAP kinase kinase kinase SSK2

1

2

High-throughput

0.500

High

604457

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

2

High-throughput

0.500

High

549700

STI1
Heat shock protein STI1

1

2

High-throughput

0.494

High

604391

TAF5
Transcription initiation factor TFIID subunit 5

1

6

High-throughput

0.489

High

599417

VPS1
Vacuolar protein sorting-associated protein 1

1

2

Small-scale

0.481

High

604399

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.479

High

141155

RS9A
Small ribosomal subunit protein uS4A

1

1

High-throughput

0.479

High

365797

HSP82
ATP-dependent molecular chaperone HSP82

1

3

High-throughput

0.479

High

425769

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.479

High

479924

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.479

High

543204

HSC82
ATP-dependent molecular chaperone HSC82

1

3

High-throughput

0.479

High

549953

CSK21
Casein kinase II subunit alpha

1

4

Small-scale

0.479

High

604351

VPS34
Phosphatidylinositol 3-kinase VPS34

1

5

High-throughput

0.479

High

604358

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.479

High

604362

HS104
Heat shock protein 104

1

1

High-throughput

0.479

High

604365

ARP2
Actin-related protein 2

1

1

High-throughput

0.479

High

604395

ATG8
Autophagy-related protein 8

1

11

Small-scale

0.479

High

604400

ARPC1
Actin-related protein 2/3 complex subunit 1

1

7

High-throughput

0.479

High

604419

RSP5
E3 ubiquitin-protein ligase RSP5

1

4

Small-scale

0.479

High

604436

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

7

High-throughput

0.479

High

604439

ARP3
Actin-related protein 3

1

1

High-throughput

0.479

High

604459

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

604480

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.479

High

604485

RS10A
Small ribosomal subunit protein eS10A

1

4

High-throughput

0.479

High

357885

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.458

High

382953

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.458

High

405433

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.458

High

406789

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

407729

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

413307

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

470864

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.458

High

480485

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.458

High

482085

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

604355

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

604374

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

604376

ARPC4
Actin-related protein 2/3 complex subunit 4

1

0

High-throughput

0.458

High

604379

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.458

High

604381

AP1S1
AP-1 complex subunit sigma-1

1

0

Small-scale

0.458

High

604383

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

604408

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.458

High

604416

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.458

High

604427

ARPC5
Actin-related protein 2/3 complex subunit 5

1

0

High-throughput

0.458

High

604443

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

604451

ARPC2
Actin-related protein 2/3 complex subunit 2

1

0

High-throughput

0.458

High

604483

MCA1
Metacaspase-1

1

0

High-throughput

0.458

High

604487

CHS5
Chitin biosynthesis protein CHS5

1

0

Small-scale

0.458

High

604424

VPS27
Vacuolar protein sorting-associated protein 27

1

16

Small-scale

0.457

High

604489

UBX3
UBX domain-containing protein 3

1

1

Small-scale

0.457

High

339437

CDK1
Cyclin-dependent kinase 1

1

2

High-throughput

0.457

High

429628

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

1

High-throughput

0.457

High

589057

PRP4
U4/U6 small nuclear ribonucleoprotein PRP4

1

6

High-throughput

0.457

High

604349

DBF2
Cell cycle protein kinase DBF2

1

4

High-throughput

0.457

High

604352

MEK1
Meiosis-specific serine/threonine-protein kinase MEK1

1

1

High-throughput

0.457

High

604364

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

3

High-throughput

0.457

High

604406

KOG1
Target of rapamycin complex 1 subunit KOG1

1

3

High-throughput

0.457

High

604411

TEM1
Protein TEM1

1

4

High-throughput

0.457

High

604420

PTP3
Tyrosine-protein phosphatase 3

1

1

High-throughput

0.457

High

604456

CDC14
Tyrosine-protein phosphatase CDC14

1

6

High-throughput

0.457

High

604468

UTP5
U3 small nucleolar RNA-associated protein 5

1

5

High-throughput

0.457

High

604470

KU80
ATP-dependent DNA helicase II subunit 2

1

1

High-throughput

0.457

High

604495

HSH49
Protein HSH49

1

1

High-throughput

0.457

High

510271

SSB1
Ribosome-associated molecular chaperone SSB1

1

7

High-throughput

0.445

High

604380

SPT7
Transcriptional activator SPT7

1

3

High-throughput

0.445

High

604413

XDJ1
DnaJ protein homolog XDJ1

1

1

High-throughput

0.445

High

604423

SSB2
Ribosome-associated molecular chaperone SSB2

1

7

High-throughput

0.445

High

604429

DJP1
DnaJ-like protein 1

1

1

High-throughput

0.445

High

604377

SNC2
Synaptobrevin homolog 2

1

0

High-throughput

0.438

High

355349

H2B1
Histone H2B.1

1

1

High-throughput

0.437

High

355779

H2B2
Histone H2B.2

1

1

High-throughput

0.437

High

572725

PDI
Protein disulfide-isomerase

1

1

High-throughput

0.437

High

604366

EUG1
Protein disulfide-isomerase EUG1

1

1

High-throughput

0.437

High

604385

CENPA
Histone H3-like centromeric protein CSE4

1

2

High-throughput

0.437

High

604402

ECM29
Proteasome component ECM29

1

3

High-throughput

0.437

High

604455

H3
Histone H3

1

2

High-throughput

0.437

High

604461

TOM1
E3 ubiquitin-protein ligase TOM1

1

4

High-throughput

0.437

High

604465

RUVB1
RuvB-like protein 1

1

1

High-throughput

0.437

High

367742

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

604410

SNF11
Transcription regulatory protein SNF11

1

0

High-throughput

0.426

High

604446

SOL1
6-phosphogluconolactonase-like protein 1

1

0

High-throughput

0.426

High

360737

TBB
Tubulin beta chain

1

1

High-throughput

0.407

High

555813

VATB
V-type proton ATPase subunit B

1

2

High-throughput

0.407

High

604403

SSZ1
Ribosome-associated complex subunit SSZ1

1

6

High-throughput

0.407

High

604445

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

2

High-throughput

0.407

High

604464

WDR59
Maintenance of telomere capping protein 5

1

9

High-throughput

0.407

High

604474

ARPC3
Actin-related protein 2/3 complex subunit 3

2

0

High-throughput

0.320

High

516962

INO1
Inositol-3-phosphate synthase

1

0

High-throughput

0.282

High

604388

PAM1
Protein PAM1

1

0

High-throughput

0.279

Low

604390

PP2C4
Protein phosphatase 2C homolog 4

1

0

High-throughput

0.279

Low

604472

TAF9
Transcription initiation factor TFIID subunit 9

1

0

High-throughput

0.279

Low

604494

SUS1
Transcription and mRNA export factor SUS1

1

0

High-throughput

0.279

Low

393885

PHR
Deoxyribodipyrimidine photo-lyase, mitochondrial

1

0

High-throughput

0.261

Low

541519

AMPL
Vacuolar aminopeptidase 1

1

0

High-throughput

0.261

Low

549785

UBC4
Ubiquitin-conjugating enzyme E2 4

1

0

High-throughput

0.261

Low

566127

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.261

Low

586359

PRP6
Pre-mRNA-splicing factor 6

1

0

High-throughput

0.261

Low

599955

RIR3
Ribonucleoside-diphosphate reductase large chain 2

1

0

High-throughput

0.261

Low

604354

YCP2
Uncharacterized protein YCR001W

1

0

High-throughput

0.261

Low

604356

DMC1
Meiotic recombination protein DMC1

1

0

High-throughput

0.261

Low

604357

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

0

High-throughput

0.261

Low

604373

SLX5
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5

1

0

High-throughput

0.261

Low

604375

SUI1
Eukaryotic translation initiation factor eIF-1

1

0

High-throughput

0.261

Low

604396

MOH1
Protein yippee-like MOH1

1

0

High-throughput

0.261

Low

604398

SHE3
SWI5-dependent HO expression protein 3

1

0

High-throughput

0.261

Low

604407

UTP9
U3 small nucleolar RNA-associated protein 9

1

0

High-throughput

0.261

Low

604418

VPS8
Vacuolar protein sorting-associated protein 8

1

0

High-throughput

0.261

Low

604435

SKP2
F-box protein SKP2

1

0

High-throughput

0.261

Low

604437

YFI6
Uncharacterized protein YFR016C

1

0

High-throughput

0.261

Low

604453

OCA2
Tyrosine-protein phosphatase-like protein OCA2

1

0

High-throughput

0.261

Low

604466

VPS64
Vacuolar protein sorting-associated protein 64

1

0

High-throughput

0.261

Low

604467

MUS81
Crossover junction endonuclease MUS81

1

0

High-throughput

0.261

Low

604469

PEX12
Peroxisome assembly protein 12

1

0

High-throughput

0.261

Low

604471

SPC24
Kinetochore protein SPC24

1

0

High-throughput

0.261

Low

604479

PRP11
Pre-mRNA-splicing factor PRP11

1

0

High-throughput

0.261

Low

604482

DIA2
Protein DIA2

1

0

High-throughput

0.261

Low

604491

SWM1
Anaphase-promoting complex subunit SWM1

1

0

High-throughput

0.261

Low

604432

BUD6
Bud site selection protein 6

1

0

Small-scale

0.251

Low

604433

BNI1
Protein BNI1

1

0

Small-scale

0.251

Low

356249

H4
Histone H4

1

0

High-throughput

0.249

Low

375276

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.249

Low

525811

KEX2
Kexin

1

0

Small-scale

0.249

Low

604361

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

604368

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

0

High-throughput

0.249

Low

604382

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.249

Low

604394

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

604397

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.249

Low

604414

DHH1
ATP-dependent RNA helicase DHH1

1

0

High-throughput

0.249

Low

604422

YEY6
MYG1 protein YER156C

1

0

Small-scale

0.249

Low

604430

RLP7
Ribosome biogenesis protein RLP7

1

0

High-throughput

0.249

Low

604444

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

604454

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

604460

ESP1
Separin

1

0

High-throughput

0.249

Low

604475

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

604477

ATG23
Autophagy-related protein 23

1

0

High-throughput

0.249

Low

604481

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

604488

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.249

Low

604496

ENV10
SRP-independent targeting protein 2

1

0

High-throughput

0.249

Low

454181

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.232

Low

604360

KCC1
Calcium/calmodulin-dependent protein kinase I

1

0

High-throughput

0.232

Low

604386

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

High-throughput

0.232

Low

604393

SEA4
SEH-associated protein 4

1

0

High-throughput

0.232

Low

604409

SPT8
Transcription factor SPT8

1

0

High-throughput

0.232

Low

604415

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.232

Low

604421

SCS2
Vesicle-associated membrane protein-associated protein SCS2

1

0

High-throughput

0.232

Low

604434

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.232

Low

604441

GPC1
Glycerophosphocholine acyltransferase 1

1

0

High-throughput

0.232

Low

604452

FMP41
Uncharacterized mitochondrial hydrolase FMP41

1

0

High-throughput

0.232

Low

604484

AB140
tRNA(Thr)

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024