HitPredict

Interactor 1: RIPK1 (Q13546)
Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1)
Gene: RIPK1

Interactor 2: TCAM1 (Q8IUC6)
TIR domain-containing adapter molecule 1 (TICAM-1) (Proline-rich, vinculin and TIR domain-containing protein B) (Putative NF-kappa-B-activating protein 502H) (Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta) (MyD88-3) (TIR domain-containing adapter protein inducing IFN-beta)
Gene: TICAM1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.92 0.60 0.747

The method score is based on:

Property Details
Experiments 25736436, 15064760, 33052227, 19734906, 16281057, 15814722, 17982077, 18450748, 20200155
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation, fluorescent resonance energy transfer
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005739 - mitochondrion
GO:0005829 - cytosol
GO:0006954 - inflammatory response
GO:0010008 - endosome membrane
GO:0010628 - positive regulation of gene expression
and 4 others

more...
Homologous interactions 5

Homologous interactions

Color coding for hit scores

1 671
Hs

1 712
+ Mm
+ Hs
+ Hs
+ Mm
+ Mm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024