Protein: PBS2
MAP kinase kinase PBS2 (EC 2.7.12.2) (Polymyxin B resistance protein 2) (Suppressor of fluoride sensitivity 4)

Gene: PBS2
Organism: Saccharomyces cerevisiae S288C
Interactions: 156
UniProt ID: P08018

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0004596 - protein-N-terminal amino-acid acetyltransferase activity
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004708 - MAP kinase kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

464575

HOG1
Mitogen-activated protein kinase HOG1

10

20

Small-scale

0.974

High

464623

SSK2
MAP kinase kinase kinase SSK2

7

20

Small-scale

0.971

High

464556

STE11
Serine/threonine-protein kinase STE11

5

19

Small-scale

0.925

High

464584

PP2C1
Protein phosphatase 2C homolog 1

4

12

Small-scale

0.894

High

464559

SSK22
Serine/threonine-protein kinase SSK22

2

20

Small-scale

0.831

High

464523

PBS2
MAP kinase kinase PBS2

2

20

Small-scale

0.754

High

464625

ACT
Actin

2

7

High-throughput

0.754

High

464646

NBP2
NAP1-binding protein 2

6

1

Small-scale

0.738

High

464603

SHO1
High osmolarity signaling protein SHO1

11

0

Small-scale

0.727

High

464589

MSG5
Tyrosine-protein phosphatase MSG5

1

11

High-throughput

0.691

High

464624

NOP15
Ribosome biogenesis protein 15

1

12

High-throughput

0.691

High

464629

CDC14
Tyrosine-protein phosphatase CDC14

1

10

High-throughput

0.691

High

454676

KAPR
cAMP-dependent protein kinase regulatory subunit

1

16

High-throughput

0.647

High

464553

RAD53
Serine/threonine-protein kinase RAD53

1

19

High-throughput

0.647

High

464554

KCC2
Calcium/calmodulin-dependent protein kinase II

1

15

High-throughput

0.647

High

464617

PTK2
Serine/threonine-protein kinase PTK2/STK2

1

19

High-throughput

0.647

High

464627

RHO4
GTP-binding protein RHO4

1

20

High-throughput

0.647

High

464533

SSB1
Ribosome-associated molecular chaperone SSB1

3

20

High-throughput

0.633

High

403308

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

10

High-throughput

0.618

High

438357

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

2

High-throughput

0.618

High

464552

DBF2
Cell cycle protein kinase DBF2

1

17

High-throughput

0.618

High

464571

IRE1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

18

High-throughput

0.618

High

464574

ARP2
Actin-related protein 2

1

8

High-throughput

0.618

High

464576

MKK1
MAP kinase kinase MKK1/SSP32

1

19

Small-scale

0.618

High

464601

ARB1
ABC transporter ATP-binding protein ARB1

1

2

High-throughput

0.618

High

464630

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

20

Small-scale

0.618

High

464631

PVH1
Tyrosine-protein phosphatase YVH1

1

10

High-throughput

0.618

High

464635

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

12

High-throughput

0.618

High

464643

MRN1
RNA-binding protein MRN1

1

10

High-throughput

0.618

High

464585

GLYC
Serine hydroxymethyltransferase, cytosolic

2

3

High-throughput

0.601

High

464645

YRA1
RNA annealing protein YRA1

1

6

High-throughput

0.595

High

454053

DHE4
NADP-specific glutamate dehydrogenase 1

2

1

High-throughput

0.594

High

464593

ARO9
Aromatic amino acid aminotransferase 2

2

1

High-throughput

0.594

High

464587

OLA1
Obg-like ATPase 1

2

1

High-throughput

0.584

High

464588

EIF3A
Eukaryotic translation initiation factor 3 subunit A

2

20

High-throughput

0.584

High

464539

VATB
V-type proton ATPase subunit B

2

13

High-throughput

0.571

High

464578

RPN2
26S proteasome regulatory subunit RPN2

1

4

High-throughput

0.553

High

464535

G6PI
Glucose-6-phosphate isomerase

2

1

High-throughput

0.543

High

464568

XPO1
Exportin-1

1

19

High-throughput

0.536

High

464640

SSK1
Osmolarity two-component system protein SSK1

1

0

High-throughput

0.530

High

358937

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

7

High-throughput

0.515

High

464555

IF5A1
Eukaryotic translation initiation factor 5A-1

1

1

High-throughput

0.515

High

464558

NAP1
Nucleosome assembly protein

1

4

High-throughput

0.515

High

416842

CDC25
Cell division control protein 25

1

4

High-throughput

0.501

High

464638

CYK2
Cytokinesis protein 2

1

7

High-throughput

0.501

High

366890

ATPB
ATP synthase subunit beta, mitochondrial

1

12

High-throughput

0.500

High

367652

ENO1
Enolase 1

1

5

High-throughput

0.500

High

416344

HXKA
Hexokinase-1

1

3

High-throughput

0.500

High

439195

PDC1
Pyruvate decarboxylase isozyme 1

1

3

High-throughput

0.500

High

464526

HSP73
Heat shock protein SSA3

1

20

High-throughput

0.500

High

464542

BIP
Endoplasmic reticulum chaperone BiP

1

20

High-throughput

0.500

High

464548

HSP60
Heat shock protein 60, mitochondrial

1

18

High-throughput

0.500

High

464581

HSP79
Heat shock protein homolog SSE2

1

20

High-throughput

0.500

High

464597

SAHH
Adenosylhomocysteinase

1

5

High-throughput

0.500

High

464541

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

1

2

High-throughput

0.489

High

464608

MAM33
Mitochondrial acidic protein MAM33

1

2

High-throughput

0.489

High

464582

RGT1
Glucose transport transcription regulator RGT1

1

0

Small-scale

0.480

High

368852

SYMC
Methionine--tRNA ligase, cytoplasmic

1

4

High-throughput

0.479

High

386524

TBB
Tubulin beta chain

1

20

High-throughput

0.479

High

444393

DED1
ATP-dependent RNA helicase DED1

1

10

High-throughput

0.479

High

450492

FAS1
Fatty acid synthase subunit beta

1

2

High-throughput

0.479

High

453357

PYR1
Multifunctional protein URA2

1

13

High-throughput

0.479

High

460293

SYV
Valine--tRNA ligase, mitochondrial

1

2

High-throughput

0.479

High

464524

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

6

High-throughput

0.479

High

464525

MET3
Sulfate adenylyltransferase

1

1

High-throughput

0.479

High

464532

METK1
S-adenosylmethionine synthase 1

1

3

High-throughput

0.479

High

464537

SYKC
Lysine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.479

High

464538

HSP26
Heat shock protein 26

1

3

High-throughput

0.479

High

464544

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

7

High-throughput

0.479

High

464545

VATA
V-type proton ATPase catalytic subunit A

1

16

High-throughput

0.479

High

464547

METK2
S-adenosylmethionine synthase 2

1

3

High-throughput

0.479

High

464561

PDC6
Pyruvate decarboxylase isozyme 3

1

3

High-throughput

0.479

High

464564

BMH1
Protein BMH1

1

14

High-throughput

0.479

High

464566

MCM5
Minichromosome maintenance protein 5

1

7

High-throughput

0.479

High

464567

MCM4
DNA replication licensing factor MCM4

1

7

High-throughput

0.479

High

464577

DUR1
Urea amidolyase [Includes: Urea carboxylase

1

9

High-throughput

0.479

High

464579

CBS
Cystathionine beta-synthase

1

3

High-throughput

0.479

High

464583

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.479

High

464586

MCM7
DNA replication licensing factor MCM7

1

9

High-throughput

0.479

High

464591

RS20
Small ribosomal subunit protein uS10

1

2

High-throughput

0.479

High

464592

RPN1
26S proteasome regulatory subunit RPN1

1

6

High-throughput

0.479

High

464594

FHP
Flavohemoprotein

1

4

High-throughput

0.479

High

464595

MET10
Sulfite reductase [NADPH] flavoprotein component

1

4

High-throughput

0.479

High

464596

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

1

High-throughput

0.479

High

464602

IMB4
Importin subunit beta-4

1

10

High-throughput

0.479

High

464605

RIO2
Serine/threonine-protein kinase RIO2

1

3

High-throughput

0.479

High

464606

PRS4
26S proteasome regulatory subunit 4 homolog

1

8

High-throughput

0.479

High

464611

RL10
Large ribosomal subunit protein uL16

1

2

High-throughput

0.479

High

464612

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

464613

ARC1
tRNA-aminoacylation cofactor ARC1

1

1

High-throughput

0.479

High

464618

MET5
Sulfite reductase [NADPH] subunit beta

1

4

High-throughput

0.479

High

464620

MCM6
DNA replication licensing factor MCM6

1

10

High-throughput

0.479

High

464628

NUM1
Nuclear migration protein NUM1

1

20

High-throughput

0.479

High

464633

NAB6
RNA-binding protein NAB6

1

1

High-throughput

0.479

High

464634

RUVB1
RuvB-like protein 1

1

7

High-throughput

0.479

High

464647

RIO1
Serine/threonine-protein kinase RIO1

1

3

High-throughput

0.479

High

464600

SNU13
13 kDa ribonucleoprotein-associated protein

1

3

High-throughput

0.470

High

367466

TRPE
Anthranilate synthase component 1

1

0

High-throughput

0.458

High

416065

SYTC
Threonine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

432270

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.458

High

454187

LEUC
3-isopropylmalate dehydratase

1

0

High-throughput

0.458

High

455460

PMM
Phosphomannomutase

1

0

High-throughput

0.458

High

464534

ERF1
Eukaryotic peptide chain release factor subunit 1

1

0

High-throughput

0.458

High

464543

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

0

High-throughput

0.458

High

464549

KICH
Choline kinase

1

0

High-throughput

0.458

High

464569

CYS3
Cystathionine gamma-lyase

1

0

High-throughput

0.458

High

464590

FKS1
1,3-beta-glucan synthase component FKS1

1

0

High-throughput

0.458

High

464598

DLD3
D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3

1

0

High-throughput

0.458

High

464614

IML2
Inclusion body clearance protein IML2

1

0

High-throughput

0.458

High

464622

ZPR1
Zinc finger chaperone ZPR1

1

0

High-throughput

0.458

High

464632

ELP3
Elongator complex protein 3

1

0

High-throughput

0.458

High

464639

ELP1
Elongator complex protein 1

1

0

High-throughput

0.458

High

464641

YD073
UPF0592 protein YDL073W

1

0

Small-scale

0.458

High

464642

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

464649

JLP1
Alpha-ketoglutarate-dependent sulfonate dioxygenase

1

0

High-throughput

0.458

High

464650

PAA1
Polyamine N-acetyltransferase 1

1

0

High-throughput

0.458

High

464616

BBC1
Myosin tail region-interacting protein MTI1

1

7

High-throughput

0.457

High

464648

SMT3
Ubiquitin-like protein SMT3

1

3

High-throughput

0.457

High

464636

MYO5
Myosin-5

1

20

High-throughput

0.457

High

405002

LEU3
3-isopropylmalate dehydrogenase

1

5

High-throughput

0.457

High

425096

OTC
Ornithine carbamoyltransferase

1

11

High-throughput

0.457

High

464527

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

2

High-throughput

0.457

High

464528

HSP77
Import motor subunit, mitochondrial

1

20

High-throughput

0.445

High

464530

HSP71
Heat shock protein SSA1

1

20

High-throughput

0.445

High

464531

HSP72
Heat shock protein SSA2

1

20

High-throughput

0.445

High

464580

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

464599

HSP7E
Heat shock protein SSC3, mitochondrial

1

20

High-throughput

0.445

High

464604

SSB2
Ribosome-associated molecular chaperone SSB2

1

20

High-throughput

0.445

High

464607

6P21
6-phosphofructo-2-kinase 1

1

5

High-throughput

0.445

High

368550

PMG1
Phosphoglycerate mutase 1

1

5

High-throughput

0.437

High

399291

PYRF
Orotidine 5'-phosphate decarboxylase

1

2

High-throughput

0.437

High

441613

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.437

High

458972

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

2

High-throughput

0.437

High

464529

RL23B
Large ribosomal subunit protein uL14B

1

1

High-throughput

0.437

High

464536

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

2

High-throughput

0.437

High

464540

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

2

High-throughput

0.437

High

464546

FAS2
Fatty acid synthase subunit alpha

1

2

High-throughput

0.437

High

464550

CLH
Clathrin heavy chain

1

6

High-throughput

0.437

High

464551

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

6

High-throughput

0.437

High

464562

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.437

High

464563

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.437

High

464570

EF2
Elongation factor 2

1

3

High-throughput

0.437

High

464573

PSA5
Proteasome subunit alpha type-5

1

6

High-throughput

0.437

High

464609

DSN1
Kinetochore-associated protein DSN1

1

2

High-throughput

0.437

High

464621

MTHR2
Methylenetetrahydrofolate reductase 2

1

1

High-throughput

0.437

High

464644

AP3D
AP-3 complex subunit delta

1

4

High-throughput

0.437

High

464565

BEM1
Bud emergence protein 1

1

20

Small-scale

0.408

High

464557

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.279

Low

464610

FET4
Low-affinity Fe(2+) transport protein

1

0

High-throughput

0.279

Low

464615

NET1
Nucleolar protein NET1

1

0

High-throughput

0.279

Low

464619

BIOA
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

1

0

High-throughput

0.279

Low

464560

YCQ6
Uncharacterized protein YCR016W

1

0

High-throughput

0.261

Low

464626

PEX13
Peroxisomal membrane protein PEX13

1

0

High-throughput

0.261

Low

464637

SOV1
Protein SOV1, mitochondrial

1

0

High-throughput

0.261

Low

464572

VA0D
V-type proton ATPase subunit d

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025