HitPredict

Interactor 1: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: BBX (Q8WY36)
HMG box transcription factor BBX (Bobby sox homolog) (HMG box-containing protein 2)
Gene: BBX

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	35271311, 23752268
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 482 Hs			1 941
+	Hs
		883315 HDAC1_HUMAN (1-482): 0: 668: 100.00		SOX8_HUMAN (75-359): 5.26e-60: 213: 16.38
+	Mm
		140273 HDAC1_MOUSE (1-482): 0: 672: 99.38		Q60I23_MOUSE (39-325): 1.71e-56: 199: 17.47
+	Mm
		140241 HDAC1_MOUSE (1-482): 0: 672: 99.38		SOX2_MOUSE (39-325): 1.67e-55: 197: 17.12
+	Hs
		818023 HDAC1_HUMAN (1-482): 0: 668: 100.00		SOX2_HUMAN (39-325): 5.4e-55: 195: 17.47
+	Mm
		936399 HDAC2_MOUSE (1-478): 0: 664: 85.71		Q60I23_MOUSE (39-325): 1.71e-56: 199: 17.47
+	Hs
		818314 HDAC2_HUMAN (1-478): 0: 666: 85.92		SOX2_HUMAN (39-325): 5.4e-55: 195: 17.47
+	Mm
		818688 HDAC2_MOUSE (1-478): 0: 664: 85.71		SOX2_MOUSE (39-325): 1.67e-55: 197: 17.12
+	Hs
		1038645 HDAC1_HUMAN (1-482): 0: 668: 100.00		CIC_HUMAN (48-324): 1.44e-38: 158: 24.83
+	Hs
		1270390 HDAC2_HUMAN (1-478): 0: 666: 85.92		CIC_HUMAN (48-324): 1.44e-38: 158: 24.83
+	Hs
		727863 HDAC1_HUMAN (1-482): 0: 668: 100.00		SOX6_HUMAN (68-282): 2.73e-35: 146: 15.98
+	Hs
		727903 HDAC2_HUMAN (1-478): 0: 666: 85.92		SOX6_HUMAN (68-282): 2.73e-35: 146: 15.98
+	Hs
		177229 HDAC3_HUMAN (9-434): 0: 574: 57.94		SOX2_HUMAN (39-325): 5.4e-55: 195: 17.47
+	Mm
		1142019 Q9JM08_MOUSE (9-434): 0: 568: 57.71		Q60I23_MOUSE (39-325): 1.71e-56: 199: 17.47
+	Hs
		233836 HDAC1_HUMAN (1-482): 0: 668: 100.00		HBP1_HUMAN (57-148): 9.09e-13: 73.7: 34.41
+	Dm
		1098074 HDAC1_DROME (6-477): 0: 658: 77.33		HMG2_DROME (75-178): 1.24e-10: 66.5: 18.87
+	Hs
		177214 HDAC3_HUMAN (9-434): 0: 574: 57.94		SOX6_HUMAN (68-282): 2.73e-35: 146: 15.98