HitPredict

Interactor 1: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: PWP2A (Q96N64)
PWWP domain-containing protein 2A
Gene: PWWP2A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.60	0.726

Property	Details
Experiments	26496610, 28514442, 33961781, 35271311, 23752268
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0006338 - chromatin remodeling
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 482 Hs			1 755
+	Hs
		1270385 HDAC2_HUMAN (1-478): 0: 666: 85.92		PWP2A_HUMAN (1-755): 5.64e-106: 343: 100.00
+	Hs
		1038858 HDAC1_HUMAN (1-482): 0: 668: 100.00		DNM3A_HUMAN (331-739): 1.19e-71: 253: 15.88
+	Hs
		1038468 HDAC1_HUMAN (1-482): 0: 668: 100.00		PWP2B_HUMAN (159-755): 9.75e-67: 233: 31.55
+	Hs
		1038774 HDAC1_HUMAN (1-482): 0: 668: 100.00		DNM3B_HUMAN (444-740): 8.42e-62: 224: 18.33
+	Hs
		1270494 HDAC2_HUMAN (1-478): 0: 666: 85.92		DNM3B_HUMAN (444-740): 8.42e-62: 224: 18.33
+	Rn
		100231 F7ENH8_RAT (1-478): 0: 664: 85.51		Q1LZ51_RAT (444-739): 4.73e-54: 202: 17.65
+	Hs
		203227 HDAC1_HUMAN (1-482): 0: 668: 100.00		SYNJ1_HUMAN (10-423): 1.01e-14: 80.7: 13.51
+	Hs
		1056969 HDAC8_HUMAN (32-371): 2.54e-139: 407: 43.11		MDC1_HUMAN (4-618): 1.16e-11: 70.7: 10.38