HitPredict

Interactor 1: CUL1 (Q13616)
Cullin-1 (CUL-1)
Gene: CUL1

Interactor 2: FBX16 (Q8IX29)
F-box only protein 16
Gene: FBXO16

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	30714168
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cullin~F-box-like
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 776 Hs			1 292
+	Hs
		1041292 CUL1_HUMAN (1-776): 0: 911: 100.00		FBW1A_HUMAN (9-238): 5.85e-60: 202: 17.24
+	Mm
		1112933 CUL1_MOUSE (1-776): 0: 912: 99.87		FBW1A_MOUSE (9-238): 1.2e-59: 201: 16.86
+	Hs
		1041266 CUL1_HUMAN (1-776): 0: 911: 100.00		FBW1B_HUMAN (1-234): 1.94e-56: 191: 16.29
+	Mm
		1351516 CUL1_MOUSE (1-776): 0: 912: 99.87		Q9QUH1_MOUSE (30-179): 6.48e-42: 151: 23.18
+	Hs
		1041272 CUL1_HUMAN (1-776): 0: 911: 100.00		FBXW2_HUMAN (30-179): 7.98e-42: 151: 23.18
+	Hs
		1041133 CUL1_HUMAN (1-776): 0: 911: 100.00		FBXW7_HUMAN (1-237): 3.19e-38: 144: 18.70
+	Mm
		1257398 CUL1_MOUSE (1-776): 0: 912: 99.87		FBXW7_MOUSE (4-237): 1.06e-37: 143: 18.60
+	Hs
		1041090 CUL1_HUMAN (1-776): 0: 911: 100.00		FBXW8_HUMAN (88-167): 5.13e-24: 103: 31.25
+	Mm
		1206618 CUL1_MOUSE (1-776): 0: 912: 99.87		FBXW8_MOUSE (88-167): 1.33e-22: 99.1: 30.00
+	Hs
		1043319 CUL4A_HUMAN (7-776): 0: 781: 30.41		FBW1A_HUMAN (9-238): 5.85e-60: 202: 17.24
+	Hs
		1041264 CUL1_HUMAN (1-776): 0: 911: 100.00		FBXL5_HUMAN (89-133): 1.45e-10: 63.7: 42.22
+	Hs
		1041263 CUL1_HUMAN (1-776): 0: 911: 100.00		FBX3_HUMAN (89-157): 6.04e-10: 61.4: 31.88
+	Hs
		1043297 CUL4A_HUMAN (7-776): 0: 781: 30.41		FBW1B_HUMAN (1-234): 1.94e-56: 191: 16.29
+	Hs
		1041217 CUL1_HUMAN (1-776): 0: 911: 100.00		FBX6_HUMAN (87-167): 3.81e-09: 58.3: 28.05
+	Hs
		1043637 CUL4B_HUMAN (7-776): 0: 773: 29.90		FBW1B_HUMAN (1-234): 1.94e-56: 191: 16.29
+	Dm
		1097201 CUL1_DROME (4-776): 0: 770: 61.98		Q9VDE3_DROME (8-236): 1.34e-50: 175: 15.56
+	Hs
		1043499 CUL4B_HUMAN (7-776): 0: 773: 29.90		FBXW7_HUMAN (1-237): 3.19e-38: 144: 18.70
+	Hs
		1043100 CUL4A_HUMAN (7-776): 0: 781: 30.41		FBXW8_HUMAN (88-167): 5.13e-24: 103: 31.25
+	Hs
		1043454 CUL4B_HUMAN (7-776): 0: 773: 29.90		FBXW8_HUMAN (88-167): 5.13e-24: 103: 31.25
+	Hs
		1043296 CUL4A_HUMAN (7-776): 0: 781: 30.41		FBX3_HUMAN (89-157): 6.04e-10: 61.4: 31.88