HitPredict

Interactor 1: CUL2 (Q13617)
Cullin-2 (CUL-2)
Gene: CUL2

Interactor 2: APBP2 (Q92624)
Amyloid protein-binding protein 2 (Amyloid beta precursor protein-binding protein 2) (APP-BP2) (Protein interacting with APP tail 1)
Gene: APPBP2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	18187417, 33961781, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0016567 - protein ubiquitination GO:0031462 - Cul2-RING ubiquitin ligase complex
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 745 Hs			1 585
+	Hs
		1041364 CUL2_HUMAN (1-745): 0: 840: 100.00		KLC3_HUMAN (39-234): 1.52e-22: 103: 14.80
+	Hs
		174870 CUL4B_HUMAN (4-745): 0: 771: 27.79		OGT1_HUMAN (53-400): 8.43e-33: 136: 13.71
+	Hs
		174869 CUL3_HUMAN (1-745): 0: 768: 26.38		OGT1_HUMAN (53-400): 8.43e-33: 136: 13.71
+	Hs
		1043253 CUL4A_HUMAN (4-745): 0: 773: 26.86		KLC4_HUMAN (39-324): 1.86e-28: 121: 14.14
+	Hs
		992338 CUL3_HUMAN (1-745): 0: 768: 26.38		KLC1_HUMAN (39-304): 1.35e-28: 122: 14.13