HitPredict

Interactor 1: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Interactor 2: MARK2 (Q7KZI7)
Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b)
Gene: MARK2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	15778465, 36736316
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0045296 - cadherin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 788
+	Hs
		971697 1433E_HUMAN (2-246): 4.43e-146: 410: 60.41		MARK2_HUMAN (1-788): 0: 797: 100.00
+	Mm
		972209 1433E_MOUSE (2-246): 4.43e-146: 410: 60.41		MARK2_MOUSE (1-788): 0: 769: 96.57
+	Hs
		692004 1433S_HUMAN (1-248): 3.5e-158: 440: 100.00		MARK3_HUMAN (3-788): 0: 664: 60.15
+	Hs
		730927 1433S_HUMAN (1-248): 3.5e-158: 440: 100.00		MARK1_HUMAN (3-788): 0: 649: 63.35
+	Hs
		692031 1433E_HUMAN (2-246): 4.43e-146: 410: 60.41		MARK3_HUMAN (3-788): 0: 664: 60.15
+	Mm
		972206 1433E_MOUSE (2-246): 4.43e-146: 410: 60.41		MARK3_MOUSE (3-788): 0: 661: 59.40
+	Mm
		972294 1433E_MOUSE (2-246): 4.43e-146: 410: 60.41		MARK1_MOUSE (3-788): 0: 648: 64.82
+	Mm
		972284 1433E_MOUSE (2-246): 4.43e-146: 410: 60.41		MARK4_MOUSE (1-788): 0: 575: 48.52
+	Hs
		971530 1433E_HUMAN (2-246): 4.43e-146: 410: 60.41		MELK_HUMAN (44-788): 9.73e-177: 524: 25.17
+	Hs
		730912 1433S_HUMAN (1-248): 3.5e-158: 440: 100.00		SNRK_HUMAN (48-787): 1.3e-148: 455: 23.85
+	Hs
		730878 1433S_HUMAN (1-248): 3.5e-158: 440: 100.00		SIK2_HUMAN (34-733): 1.12e-143: 447: 31.32
+	Hs
		730472 1433S_HUMAN (1-248): 3.5e-158: 440: 100.00		SIK1_HUMAN (31-693): 2.34e-141: 437: 31.99
+	Hs
		730557 1433S_HUMAN (1-248): 3.5e-158: 440: 100.00		AAPK1_HUMAN (31-553): 3.89e-142: 431: 29.74
+	Hs
		730751 1433S_HUMAN (1-248): 3.5e-158: 440: 100.00		BRSK2_HUMAN (43-481): 7.98e-137: 424: 37.11
+	Hs
		943639 1433E_HUMAN (2-246): 4.43e-146: 410: 60.41		SIK1_HUMAN (31-693): 2.34e-141: 437: 31.99
+	Rn
		930528 1433E_RAT (2-246): 4.43e-146: 410: 60.41		AAPK1_RAT (31-553): 5.91e-142: 431: 29.74
+	Hs
		971469 1433E_HUMAN (2-246): 4.43e-146: 410: 60.41		AAPK1_HUMAN (31-553): 3.89e-142: 431: 29.74
+	Mm
		972247 1433E_MOUSE (2-246): 4.43e-146: 410: 60.41		BRSK2_MOUSE (34-481): 1.5e-137: 426: 36.60
+	Hs
		971753 1433E_HUMAN (2-246): 4.43e-146: 410: 60.41		BRSK2_HUMAN (43-481): 7.98e-137: 424: 37.11
+	Hs
		730975 1433S_HUMAN (1-248): 3.5e-158: 440: 100.00		SIK3_HUMAN (50-361): 5.16e-110: 366: 58.44