HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: RHBT2 (Q9BYZ6)
Rho-related BTB domain-containing protein 2 (Deleted in breast cancer 2 gene protein) (p83)
Gene: RHOBTB2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.931

Property	Details
Experiments	15107402, 18835386, 21145461, 29276004, 34591642
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	BTB~Cullin
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Hs			1 727
+	Hs
		297618 CUL3_HUMAN (1-768): 0: 951: 100.00		RHBT1_HUMAN (1-708): 6.34e-160: 480: 67.65
+	Hs
		301202 CUL3_HUMAN (1-768): 0: 951: 100.00		RHBT3_HUMAN (82-686): 4.81e-87: 287: 20.52
+	Hs
		893985 CUL3_HUMAN (1-768): 0: 951: 100.00		CDC42_HUMAN (12-218): 7.09e-92: 286: 36.67
+	Hs
		1042716 CUL3_HUMAN (1-768): 0: 951: 100.00		IBTK_HUMAN (234-664): 5.54e-81: 283: 17.57
+	Mm
		1169620 CUL3_MOUSE (1-768): 0: 949: 99.48		IBTK_MOUSE (234-665): 2.07e-78: 276: 16.26
+	Hs
		1042047 CUL3_HUMAN (1-768): 0: 951: 100.00		ABTB2_HUMAN (231-647): 1.15e-77: 271: 17.08
+	Hs
		214258 CUL3_HUMAN (1-768): 0: 951: 100.00		SPOP_HUMAN (305-670): 2.13e-72: 241: 13.30
+	Hs
		1041805 CUL3_HUMAN (1-768): 0: 951: 100.00		SPOPL_HUMAN (313-670): 9.29e-70: 235: 14.25
+	Hs
		925262 CUL3_HUMAN (1-768): 0: 951: 100.00		RAC1_HUMAN (12-220): 1.16e-71: 233: 35.38
+	Hs
		900452 CUL3_HUMAN (1-768): 0: 951: 100.00		RHOA_HUMAN (16-216): 1.94e-70: 230: 35.29
+	Hs
		1042510 CUL3_HUMAN (1-768): 0: 951: 100.00		RAB1B_HUMAN (1-240): 2.33e-69: 227: 18.93
+	Hs
		1274039 CUL5_HUMAN (25-768): 0: 597: 23.77		RHBT2_HUMAN (1-705): 9.08e-177: 524: 100.00
+	Dm
		1213841 Q8IP45_DROME (17-768): 0: 868: 69.08		RDX_DROME (262-670): 2.75e-71: 250: 14.32
+	Dm
		1359790 Q9V475_DROME (2-768): 0: 861: 68.77		RDX_DROME (262-670): 2.75e-71: 250: 14.32
+	Hs
		297660 CUL5_HUMAN (25-768): 0: 597: 23.77		RHBT1_HUMAN (1-708): 6.34e-160: 480: 67.65
+	Hs
		893986 CUL4A_HUMAN (10-768): 0: 791: 38.32		CDC42_HUMAN (12-218): 7.09e-92: 286: 36.67
+	Hs
		214259 CUL4A_HUMAN (10-768): 0: 791: 38.32		SPOP_HUMAN (305-670): 2.13e-72: 241: 13.30
+	Hs
		1043210 CUL4A_HUMAN (10-768): 0: 791: 38.32		RAB1B_HUMAN (1-240): 2.33e-69: 227: 18.93
+	Hs
		893984 CUL1_HUMAN (18-768): 0: 707: 30.57		CDC42_HUMAN (12-218): 7.09e-92: 286: 36.67
+	Hs
		545362 CUL1_HUMAN (18-768): 0: 707: 30.57		RAC2_HUMAN (12-219): 9.54e-73: 236: 36.97