HitPredict

Interactor 1: NOTC1 (P46531)
Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]
Gene: NOTCH1

Interactor 2: NOTC2 (Q04721)
Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)]
Gene: NOTCH2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.60 1.00 0.776

The method score is based on:

Property Details
Experiments 23022380, unassigned3799
Identification Methods affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Ank~Ank, Ank~Ank_2, Ank_2~Ank_2, EGF~EGF, EGF~EGF_CA, EGF~hEGF, EGF_CA~EGF_CA, EGF_CA~hEGF, NOD~NODP, NOD~Notch, NODP~NODP, NODP~Notch, Notch~Notch
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000139 - Golgi membrane
GO:0000987 - cis-regulatory region sequence-specific DNA binding
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001701 - in utero embryonic development
and 23 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 2555
Hs

1 2471
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Last updated: 11Aug2025