HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: BAG5 (Q9UL15)
BAG family molecular chaperone regulator 5 (BAG-5) (Bcl-2-associated athanogene 5)
Gene: BAG5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35563538, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 768 Hs			1 447
+	Hs
		314042 CUL3_HUMAN (1-768): 0: 951: 100.00		BAG4_HUMAN (363-441): 3.44e-30: 123: 44.30
+	Hs
		314043 CUL4A_HUMAN (10-768): 0: 791: 38.32		BAG4_HUMAN (363-441): 3.44e-30: 123: 44.30
+	Hs
		324385 CUL4A_HUMAN (10-768): 0: 791: 38.32		BAG3_HUMAN (361-442): 2.06e-28: 119: 44.71
+	Hs
		324386 CUL4B_HUMAN (5-768): 0: 779: 36.77		BAG3_HUMAN (361-442): 2.06e-28: 119: 44.71
+	Hs
		314040 CUL1_HUMAN (18-768): 0: 707: 30.57		BAG4_HUMAN (363-441): 3.44e-30: 123: 44.30
+	Hs
		324384 CUL1_HUMAN (18-768): 0: 707: 30.57		BAG3_HUMAN (361-442): 2.06e-28: 119: 44.71
+	Hs
		314041 CUL2_HUMAN (30-768): 0: 672: 26.17		BAG4_HUMAN (363-441): 3.44e-30: 123: 44.30
+	Hs
		314109 CUL5_HUMAN (25-768): 0: 597: 23.77		BAG4_HUMAN (363-441): 3.44e-30: 123: 44.30