HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: UBP15 (Q9Y4E8)
Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.4.19.12) (Deubiquitinating enzyme 15) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) (Unph-2) (Unph4)
Gene: USP15

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35563538, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 768 Hs			1 981
+	Hs
		1043649 CUL4B_HUMAN (5-768): 0: 779: 36.77		UBP15_HUMAN (1-981): 0: 859: 100.00
+	Hs
		850035 CUL3_HUMAN (1-768): 0: 951: 100.00		UBP11_HUMAN (9-946): 0: 661: 43.58
+	Hs
		1024326 CUL4A_HUMAN (10-768): 0: 791: 38.32		UBP4_HUMAN (1-981): 0: 794: 55.38
+	Hs
		1024327 CUL4B_HUMAN (5-768): 0: 779: 36.77		UBP4_HUMAN (1-981): 0: 794: 55.38
+	Hs
		850036 CUL4B_HUMAN (5-768): 0: 779: 36.77		UBP11_HUMAN (9-946): 0: 661: 43.58
+	Hs
		301390 CUL3_HUMAN (1-768): 0: 951: 100.00		UBP19_HUMAN (197-960): 5.82e-149: 477: 29.50
+	Hs
		850034 CUL1_HUMAN (18-768): 0: 707: 30.57		UBP11_HUMAN (9-946): 0: 661: 43.58
+	Hs
		301391 CUL4A_HUMAN (10-768): 0: 791: 38.32		UBP19_HUMAN (197-960): 5.82e-149: 477: 29.50
+	Hs
		301392 CUL4B_HUMAN (5-768): 0: 779: 36.77		UBP19_HUMAN (197-960): 5.82e-149: 477: 29.50
+	Hs
		1042807 CUL3_HUMAN (1-768): 0: 951: 100.00		UBP21_HUMAN (570-935): 1.17e-66: 236: 20.32
+	Hs
		1042855 CUL3_HUMAN (1-768): 0: 951: 100.00		UBP22_HUMAN (772-933): 1.82e-57: 208: 32.20
+	Sp
		223876 CUL3_SCHPO (11-768): 0: 648: 37.04		UBP12_SCHPO (31-933): 1.41e-163: 507: 30.66
+	Hs
		1042126 CUL3_HUMAN (1-768): 0: 951: 100.00		UBP33_HUMAN (400-652): 3.18e-25: 115: 12.38
+	Hs
		1042080 CUL3_HUMAN (1-768): 0: 951: 100.00		UBP32_HUMAN (873-972): 4.15e-22: 105: 35.00
+	Hs
		1041069 CUL1_HUMAN (18-768): 0: 707: 30.57		UBP37_HUMAN (126-958): 3.63e-87: 302: 14.10