HitPredict

Interactor 1: CAC1C (Q13936)
Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Voltage-gated calcium channel subunit alpha Cav1.2)
Gene: CACNA1C

Interactor 2: SCN2A (Q99250)
Sodium channel protein type 2 subunit alpha (HBSC II) (Sodium channel protein brain II subunit alpha) (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2)
Gene: SCN2A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	37207277
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Ion_trans~Ion_trans
Common GO terms	GO:0005516 - calmodulin binding GO:0005886 - plasma membrane GO:0016020 - membrane GO:0086002 - cardiac muscle cell action potential involved in contraction
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 2221 Hs			1 2005
+	Hs
		1047288 CAC1C_HUMAN (1-2221): 0: 1887: 100.00		SCN3A_HUMAN (1-2005): 0: 2001: 86.72
+	Hs
		1047100 CAC1C_HUMAN (1-2221): 0: 1887: 100.00		SCN9A_HUMAN (4-2005): 0: 1963: 76.32
+	Hs
		723923 SCN4A_HUMAN (7-1766): 0: 1063: 19.51		SCN8A_HUMAN (1-2004): 0: 1869: 73.68
+	Hs
		1079737 SCN9A_HUMAN (1223-1768): 4e-18: 94.2: 13.18		SCN2A_HUMAN (1-2005): 0: 2115: 100.00
+	Hs
		1303356 SCN3A_HUMAN (1197-1772): 7.14e-16: 86.5: 12.71		SCN2A_HUMAN (1-2005): 0: 2115: 100.00